scispace - formally typeset
Search or ask a question
Institution

Kyungpook National University

EducationDaegu, South Korea
About: Kyungpook National University is a education organization based out in Daegu, South Korea. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 20497 authors who have published 42107 publications receiving 834608 citations.


Papers
More filters
Journal ArticleDOI
TL;DR: In this article, a comprehensive assessment of recent studies on the removal of various contaminants of emerging concern (CECs) with different physicochemical properties by various MOF-NAs under various water quality conditions (e.g., pH, background ions/ionic strength, natural organic matter, and temperature).

270 citations

Journal ArticleDOI
TL;DR: The remarkable adsorption with ZIF-8 suggests a specific favorable interaction (electrostatic interaction) between the positively charged surface of Zif-8 and the negatively charged PA anions.

269 citations

Journal ArticleDOI
TL;DR: In this article, the morphology of polyvinylidene fluoride and polyacrylonitrile (PVdF-PAN-ESFMs) was examined by field emission scanning electron microscopy (FESEM).

269 citations

Journal ArticleDOI
TL;DR: It is concluded that subnuclear localization of Runx factors in specific foci together with associated regulatory functions is essential for control of RunX-dependent genes involved in tissue differentiation during embryonic development.
Abstract: Runx (Cbfa/AML) transcription factors are critical for tissue-specific gene expression. A unique targeting signal in the C terminus directs Runx factors to discrete foci within the nucleus. Using Runx2/CBFA1/AML3 and its essential role in osteogenesis as a model, we investigated the fundamental importance of fidelity of subnuclear localization for tissue differentiating activity by deleting the intranuclear targeting signal via homologous recombination. Mice homozygous for the deletion (Runx2ΔC) do not form bone due to maturational arrest of osteoblasts. Heterozygotes do not develop clavicles, but are otherwise normal. These phenotypes are indistinguishable from those of the homozygous and heterozygous null mutants, indicating that the intranuclear targeting signal is a critical determinant for function. The expressed truncated Runx2ΔC protein enters the nucleus and retains normal DNA binding activity, but shows complete loss of intranuclear targeting. These results demonstrate that the multifunctional N-terminal region of the Runx2 protein is not sufficient for biological activity. We conclude that subnuclear localization of Runx factors in specific foci together with associated regulatory functions is essential for control of Runx-dependent genes involved in tissue differentiation during embryonic development.

268 citations


Authors

Showing all 20671 results

NameH-indexPapersCitations
Hyun-Chul Kim1764076183227
David R. Jacobs1651262113892
Yang Yang1642704144071
Yongsun Kim1562588145619
Jongmin Lee1502257134772
Inkyu Park1441767109433
Christopher George Tully1421843111669
Teruki Kamon1422034115633
Manfred Paulini1411791110930
Kazuhiko Hara1411956107697
Luca Lista1402044110645
Dong-Chul Son138137098686
Christoph Paus1371585100801
Frank Filthaut1351684103590
Andreas Warburton135157897496
Network Information
Related Institutions (5)
Korea University
82.4K papers, 1.8M citations

98% related

Seoul National University
138.7K papers, 3.7M citations

97% related

Chonnam National University
36.1K papers, 744.2K citations

97% related

Pusan National University
45K papers, 819.3K citations

97% related

Sungkyunkwan University
56.4K papers, 1.3M citations

97% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202375
2022317
20213,152
20203,071
20192,763
20182,664