Institution
Kyungpook National University
Education•Daegu, South Korea•
About: Kyungpook National University is a education organization based out in Daegu, South Korea. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 20497 authors who have published 42107 publications receiving 834608 citations.
Topics: Population, Large Hadron Collider, Catalysis, Adsorption, Lepton
Papers published on a yearly basis
Papers
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TL;DR: In this article, a comprehensive assessment of recent studies on the removal of various contaminants of emerging concern (CECs) with different physicochemical properties by various MOF-NAs under various water quality conditions (e.g., pH, background ions/ionic strength, natural organic matter, and temperature).
270 citations
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TL;DR: The remarkable adsorption with ZIF-8 suggests a specific favorable interaction (electrostatic interaction) between the positively charged surface of Zif-8 and the negatively charged PA anions.
269 citations
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269 citations
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TL;DR: In this article, the morphology of polyvinylidene fluoride and polyacrylonitrile (PVdF-PAN-ESFMs) was examined by field emission scanning electron microscopy (FESEM).
269 citations
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TL;DR: It is concluded that subnuclear localization of Runx factors in specific foci together with associated regulatory functions is essential for control of RunX-dependent genes involved in tissue differentiation during embryonic development.
Abstract: Runx (Cbfa/AML) transcription factors are critical for tissue-specific gene expression. A unique targeting signal in the C terminus directs Runx factors to discrete foci within the nucleus. Using Runx2/CBFA1/AML3 and its essential role in osteogenesis as a model, we investigated the fundamental importance of fidelity of subnuclear localization for tissue differentiating activity by deleting the intranuclear targeting signal via homologous recombination. Mice homozygous for the deletion (Runx2ΔC) do not form bone due to maturational arrest of osteoblasts. Heterozygotes do not develop clavicles, but are otherwise normal. These phenotypes are indistinguishable from those of the homozygous and heterozygous null mutants, indicating that the intranuclear targeting signal is a critical determinant for function. The expressed truncated Runx2ΔC protein enters the nucleus and retains normal DNA binding activity, but shows complete loss of intranuclear targeting. These results demonstrate that the multifunctional N-terminal region of the Runx2 protein is not sufficient for biological activity. We conclude that subnuclear localization of Runx factors in specific foci together with associated regulatory functions is essential for control of Runx-dependent genes involved in tissue differentiation during embryonic development.
268 citations
Authors
Showing all 20671 results
Name | H-index | Papers | Citations |
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Hyun-Chul Kim | 176 | 4076 | 183227 |
David R. Jacobs | 165 | 1262 | 113892 |
Yang Yang | 164 | 2704 | 144071 |
Yongsun Kim | 156 | 2588 | 145619 |
Jongmin Lee | 150 | 2257 | 134772 |
Inkyu Park | 144 | 1767 | 109433 |
Christopher George Tully | 142 | 1843 | 111669 |
Teruki Kamon | 142 | 2034 | 115633 |
Manfred Paulini | 141 | 1791 | 110930 |
Kazuhiko Hara | 141 | 1956 | 107697 |
Luca Lista | 140 | 2044 | 110645 |
Dong-Chul Son | 138 | 1370 | 98686 |
Christoph Paus | 137 | 1585 | 100801 |
Frank Filthaut | 135 | 1684 | 103590 |
Andreas Warburton | 135 | 1578 | 97496 |