Showing papers by "Kyushu University published in 1984"
TL;DR: The development of anti-ATLA in the recipients may correspond to antibody production after establishment of primary infection with ATLV that is associated with cells in blood from anti‐ATLA‐positive donors who are ATLV carriers.
Abstract: Possible transmission of adult T cell leukemia virus (ATLV) by blood transfusion was studied retrospectively. Of 41 recipients of whole blood or blood components containing cells from donors having antibodies to antigen that is associated with ATLV (anti-ATLA), 26 (63.4%) produced anti-ATLA. However, no anti-ATLA was detected in all 14 recipients of fresh-frozen plasma prepared from anti-ATLA-positive donors. None of 252 recipients of blood with cell components from anti-ATLA-negative donors produced anti-ATLA. The development of anti-ATLA in the recipients may correspond to antibody production after establishment of primary infection with ATLV that is associated with cells in blood from anti-ATLA-positive donors who are ATLV carriers.
642 citations
TL;DR: Five hundred sixty‐two cases of angioleiomyoma in the authors' files on soft tissues were reappraised clinico‐pathologically and small groups of mature fat cells were demonstrated within the tumor, suggesting the hamartomatous nature of these smooth muscle tumors.
Abstract: Five hundred sixty-two cases of angioleiomyoma in our files on soft tissues were reappraised clinicopathologically. There was a preponderance in females with a ratio of 1.7:1. The angioleiomyoma could be separated into three histologic subtypes: capillary or solid (374 cases), cavernous (61 cases), and venous (127 cases) types. Five hundred (89%) occurrences were in the extremities, 48 in the head, and only 14 in the trunk. The tumors caused pain and/or tenderness in 327 cases, in which 262 were of the solid type. In 16 cases, small groups of mature fat cells were demonstrated within the tumor, suggesting the hamartomatous nature of these smooth muscle tumors.
484 citations
TL;DR: In this paper, the mixed micelle formation of surfactants was treated thermodynamically as the appearance of a macroscopic bulk phase with the aid of the excess thermodynamic quantities similar to those used for the adsorbed film.
Abstract: In conformity with the conclusion obtained previously, the mixed micelle formation of surfactants was treated thermodynamically as the appearance of a macroscopic bulk phase with the aid of the excess thermodynamic quantities similar to those used for the adsorbed film. The composition of surfactant in the mixed micelle and the thermodynamic quantities of micelle formation were found to be evaluated by applying the thermodynamic equations derived. These equations were extended so as to be applicable to any kind of surfactant mixture. It was shown that the critical micelle concentration vs. composition of surfactant curves form a diagram analogous to the phase diagram of binary mixture. Applying the equation to the published data on typical surfactant systems, this thermodynamic approach was proved to be useful to clarify the miscibility of surfactants in the micellar state.
378 citations
TL;DR: Effects of inositol 1,4,5- trisphosphate, extracted from human erythrocyte ghosts, on Ca2+ release from intracellular store sites were studied in saponin-treated single muscle cells of the porcine coronary artery and this agent may play the role of messenger in increasing the cytosolic Ca2+, provoking pharmaco-mechanical coupling, and thus producing the contraction.
350 citations
TL;DR: A new mutation (recQ1) located between corA and metE on the standard linkage map was found to result in increased sensitivity to ultraviolet light and deficiency in conjugational recombination when placed in the recBC sbcB background, indicating that it blocked the RecF pathway of recobbination.
Abstract: An Escherichia coli K12 mutant resistant to thymineless death (TLD) was isolated, and its genetic analysis led us to identify a new mutation (recQ1) located between corA and metE on the standard linkage map. The mutation was found to result in increased sensitivity to ultraviolet light and deficiency in conjugational recombination when placed in the recBC sbcB background, indicating that it blocked the RecF pathway of recobbination. It seemed likely that this mutation is also capable of causing partial resistance to TLD, but we reserve the possibility of a separate mutation closely linked to recQ1 giving rise to this phenotype. The original mutant was shown to carry an additional mutation probably in the vicinity of the uhp locus, which was also required for the full TLD resistance of the mutant to be expressed.
242 citations
TL;DR: Intracellular horseradish peroxidase staining of NTS neurons revealed that glucose-sensitive neurons were medium-sized, fusiform or pyramidal cells with many more dendrites than non-responding small oval cells.
241 citations
TL;DR: The findings suggest that the neural network of the glucose monitoring system, which also analyzes and integrates information concerning other metabolites and peptides in the blood and cerebrospinal fluid, contributes to regulation of peripheral metabolism and endocrine activity as well as feeding behavior.
Abstract: Glucose-sensitive neural elements exist in the hypothalamus, the nucleus of the solitary tract (NTS) and autonomic afferents from visceral organs such as liver and gastrointestinal tract. Glucose affects neural activity through these central and peripheral chemosensors. Glucose is generally suppressive in the liver, the NTS and the lateral hypothalamic area (LHA), and generally excitatory in the small intestine and ventromedial hypothalamic nucleus (VMH). The hypothalamus is involved in the control of pancreatic hormone secretion through autonomic efferent nerves. Stimulation or lesion of the hypothalamus induces various changes in pancreatic autonomic nerve activity. The VMH, the dorsomedial hypothalamic nucleus and the paraventricular nucleus have inhibitory effects on vagal nerve activity and excitatory effects on splanchnic nerve activity. The LHA is excitatory to the vagal nerve, and both excitatory and inhibitory to the splanchnic nerve. These findings suggest that the neural network of the glucose monitoring system, which also analyzes and integrates information concerning other metabolites and peptides in the blood and cerebrospinal fluid, contributes to regulation of peripheral metabolism and endocrine activity as well as feeding behavior. The physiological function and input-output organization of this network are discussed.
232 citations
TL;DR: It is shown that for one type of acceptance condition alternation increases the power in comparison with nondeterminism and for other three acceptance conditions nondeterministic finite automata on ω-words have the same power as alternating ones.
229 citations
TL;DR: A clinicopathological analysis was made of data from 250 cases of nodular fasciitis, finding that the mitotically active myxoid form tended to have the shortest history, the fibrous type the longest, while that of the cellular group was of intermediate duration.
227 citations
TL;DR: Occult and cirrhotic types of HCC showed a longer survival than frank and febrile types that had a mean survival time of all patients, and the prognosis of icteric and metastatic types was poorest.
Abstract: The natural course of hepatocellular carcinoma (HCC) was evaluated in 100 untreated patients who were seen during recent 13 years. There were 80 males and 20 females. The macroscopic type of tumor was massive in 58, nodular in 35, and diffuse in 7 cases. Liver cirrhosis was associated with in 80% of patients. The mean survival time of overall patients was 4 months from the onset of initial symptoms to death and 2 months from admission to death. Occult and cirrhotic types of HCC showed a longer survival than frank and febrile types that had a mean survival time of all patients. The prognosis of icteric and metastatic types was poorest. Sex, tumor type, or associated cirrhosis did not substantially affect the natural course of HCC. The tumor stage and clinical stage were grossly correlated to the prognosis. In terms of symptoms, severe jaundice and ascites were the most dismal prognostic signs.
207 citations
TL;DR: 1-Oleoyl-2-acetyl-glycerol, which activates Ca2+-activated phospholipid-dependent protein kinase, induced the superoxide-production of human neutrophils, while other diacylglycerols did not, indicating the possible involvement of the kinase in the induction process.
TL;DR: In this article, the authors investigated the effect of surface orientation on nucleate boiling heat transfer and proposed two mechanisms of the sensible heat transport by compulsory removal of the thermal layer by the rising bubble and the latent heat transfer by evaporation from thin liquid film underneath the bubble.
TL;DR: In this paper, the equations du groupe de renormalisation dans le modele de jauge minimal SU(3)×SU(2)×U(1) a supersymetrie brisee doucement are considered.
Abstract: On considere les equations du groupe de renormalisation dans le modele de jauge minimal SU(3)×SU(2)×U(1) a supersymetrie brisee doucement
TL;DR: The complete nucleotide sequence of the genome of 17.6 is determined, which shows that it contains three long open reading frames comparable with gag, pol and env genes in retrovirus, and includes a coding sequence similar to that for reverse transcriptase, suggesting a role for this enzyme in the life cycle of some Drosophila copia-like elements, analogous to the situation in Retrovirus.
Abstract: The largest group of transposable elements in Drosophila melanogaster, copia-like elements1,2, share some important structural features with and are intimately related in evolution to vertebrate retroviruses2–12. To further clarify the relationship between retroviruses and copia-like transposable elements, we set out to determine the complete nucleotide sequence of the genome of 17.6, which has long terminal repeats homologous in nucleotide sequence to those of avian leukaemia–sarcoma virus12. We report here that 17.6 contains three long open reading frames comparable with gag, pol and env genes in retrovirus. At the level of amino acid sequence, the longest open reading frame of 17.6 includes a coding sequence similar to that for reverse transcriptase, suggesting a role for this enzyme in the life cycle of some Drosophila copia-like elements, analogous to the situation in retrovirus.
TL;DR: It is concluded that glucose-sensitive neurons exist within the NTS and also that they are functionally linked with hepatoportal glucose- sensitive afferent units.
TL;DR: In this paper, a new statistical-mechanical theory of diffusion-controlled droplet coarsening is presented, where a spatial graining is carried out in a manner consistent with an expansion in droplet volume fraction φ to obtain kinetic equations for a single distribution function of droplets.
Abstract: A new statistical-mechanical theory of diffusion-controlled droplet coarsening is presented. With the aid of a scaling expansion method, a spatial graining is carried out in a manner consistent with an expansion in droplet volume fraction φ to obtain kinetic equations for a single distribution function of droplets. It is shown that there two characteristic stages of coarsening, depending on their space-time scales; an intermediate stage and a late stage. In both stages, new kinetic equations are systematically derived to order φ . These equations have two terms at order φ ; a collisionless drift term and a collision term. The collision term is shown to be different from the conventional encounter integral discussed by Lifshitz and Slyozov since the former is of order φ and describes distant (soft) collisions, while the latter is of order φ and describes close (hard) collisions. It is shown in both stages that the mean droplet radius increases as the cube root of the time (t 1 3 ). A scaling behavior of the distribution function is also found in both stages. In particular, in the late stage this scaling behavior is shown to coincide with that obtained by Lifshitz and Slysov in the limit φ→O. It is also pointed out that a naive expansion in powers of φ breaks down due to the long -range nature of interactions among droplets through diffusions. Fluctuations around the kinetic equations are also explicitly explored. They are shown to be nonthermal fluctuations generated by the soft collision process and to be small. Especially, in the late stage they are shown to obey a linear Gaussian Markov process, satisfying a fluctuation-dissipation relation of the second kind.
TL;DR: The effects of inositol 1,4,5-trisphosphate, prepared from human erythrocyte ghosts, on Ca2+ release from intracellular store sites were studied in saponin-treated guinea pig peritoneal macrophages.
Abstract: The effects of inositol 1,4,5-trisphosphate, prepared from human erythrocyte ghosts, on Ca2+ release from intracellular store sites were studied in saponin-treated guinea pig peritoneal macrophages. Micromolar concentrations of inositol 1,4,5-trisphosphate released Ca2+ within 1 min from store sites which had accumulated Ca2+ in the presence of 10 mM-NaN3. In the presence of 10 mM-NaN3, the Ca2+ accumulated in the presence of oxalate was seen in the endoplasmic reticulum of saponin-treated macrophages by electron microscopy, indicating that the site of Ca2+ released by inositol 1,4,5-trisphosphate may be endoplasmic reticulum-like membranes. When the concentrations of free Ca2+ were over 3.5 X 10(-6) M, the release of Ca2+ by this agent was inhibited. This inhibition may be due to either the higher concentration of extra-vesicular free Ca2+ or the larger accumulation of Ca2+ into the store site or perhaps both effects. MgCl2 also had an inhibitory effect on the Ca2+ release. Inositol 1,4,5-trisphosphate also released Ca2+ from cardiac sarcoplasmic reticulum, but not from erythrocyte inside-out vesicles.
TL;DR: The findings suggest that hypothalamic modulation of pancreatic hormone secretion involves both the parasympathetic and sympathetic nervous systems, and provide evidence that not only the VMH and the LHA but also the DMH and a paraventricular nuclei are involved in this mechanism.
TL;DR: The effects of arginine-vasopressin on the excitability of 47 pyramidal cells of the CA1 region of the hippocampus were determined by using intracellular recording techniques in a submerged slice preparation to suggest that the action of AVP on CA1 pyramid cells is transsynaptic and is more pronounced in ventral than dorsal CA1.
TL;DR: It is demonstrated that the frequency of seropositive donors increased with age, and that four centers in this district showed distinctly high incidences of seropsitive donors, while the other four centers showed low incidences.
Abstract: A nation-wide survey of carriers of adult T-cell leukemia virus (ATLV) detected as anti-ATLA (ATLV-associated antigens) in volunteer blood donors was made in Japan. A total of 200 sera from donors between 40 and 64 years of age, collected in each of 64 blood centers located in eight districts, were tested for anti-ATLA by an indirect immunofluorescence test. The highest rate (8%) of seropositive donors was found in Kyushu and lower rates of 0.3 to 1.2% in other districts. However, the positive rate varied considerably in different localities even within districts with a high or low seropositive incidence. Further studies of all the donors (16 to 64 years old) in eight centers in Kyushu demonstrated two facts: (1) that the frequency of seropositive donors increased with age, and (2) that four centers in this district showed distinctly high incidences of seropositive donors, while the other four centers showed low incidences. The seropositive rate among all donors was estimated to be about 3% in Kyushu and 0.08 to 0.3% in all other districts.
TL;DR: This work proposes “Lipiodolization” of water‐soluble agents using as an intermediate Urografin, a water-soluble contrast medium for Lipiodol Ultra‐Fluid application through arteries feeding the tumor.
Abstract: Lipiodol Ultra-Fluid (Lipiodol) remains selectively in the tumor for an extended time when applied through arteries feeding the tumor. Although lipophilic antitumor drugs are selective when combined with Lipiodol, wide application of common hydrophilic agents is limited, as these compounds are insoluble in oil. We propose "Lipiodolization" of water-soluble agents using as an intermediate Urografin, a water-soluble contrast medium. Thirteen patients with primary hepatocellular carcinoma were treated with this Lipiodol-Urografin system containing antitumor agents. Marked decrease in serum alpha-fetoprotein (AFP) levels, decrease in tumor size in the hepatic imaging, and histologic studies of the resected specimen revealed this mode of therapy to be effective in 10 of 13 patients (77%) with hepatocellular carcinoma. Lipiodolization of antitumor agents is a new approach to selective cancer chemotherapy.
TL;DR: The breakage of double‐strand (ds) DNA by 13‐L‐hydroperoxy‐cis‐9, trans‐11‐octadecadienoic acid (LAHPO) was investigated and the active oxygen atom of the hydroperoxy group of LAHPO was perhaps responsible for the site‐specific cleavage of dsDNA.
TL;DR: Trans-2,5-Bis(methoxymethyl)- and trans-2.5-bis(methyl)pyrrolidines proved to be excellent chiral auxiliaries for the asymmetric alkylation of the corresponding carboxyamide enolates giving good chemical yield and high stereoselectivity as discussed by the authors.
TL;DR: In this article, the tension and bending of finite thickness plates with a semi-elliptical surface crack is analyzed by means of a modified body force method, in which the accuracy and validity are greatly improved by using reasonable patterns of the body force densities and the resultant force boundary conditions.
Abstract: This paper deals with the tension and bending of finite thickness plates with a semi-elliptical surface crack. The analysis is performed by means of a modified body force method, in which the accuracy and the validity are greatly improved by using reasonable patterns of the body force densities and the resultant force boundary conditions. Numerical calculations are done for various combinations of the shape and the size of the crack, and practically exact values of the stress intensity factors are determined by extrapolating the numerical results for several mesh patterns. Empirical formulae in polynomial forms are also presented for convenience of practical use.
TL;DR: CDNA for normal human prealbumin was cloned and its nucleotide sequence was determined, and results showed that the nucleotide substitution responsible for the Val----Met change results in formation of new restriction sites for BalI and NsiI.
TL;DR: In particular, the mean base pressure of a rectangular cylinder can be varied significantly by both the scale and intensity of turbulence, and the consequences of increased mixing and weakened regular vortex shedding depend on the depth-to-height ratio.
Abstract: There are two main effects of turbulence on the mean flow past rectangular cylinders, just as found earlier for square rods. Small-scale turbulence increases the growth rate of the separated shear layers through increased mixing. Large-scale turbulence weakens regular vortex shedding by reducing spanwise correlation. The consequences of increased mixing and weakened regular vortex shedding depend on the depth-to-height ratio of a rectangular cylinder. In particular, the mean base pressure of a rectangular cylinder can be varied significantly by both the scale and intensity of turbulence.
TL;DR: The results indicate the isolation of a B. thuringiensis strain which shows the same toxicity as that of subsp.
TL;DR: In this paper, the surface tension at the aqueous solution/air interface has been measured for eight surface active substances at 298.15°K under atmospheric pressure, and it has been found that each surface tension versus concentration curve has a distinct break at a relatively low concentration and a relatively high surface tension.
TL;DR: The present results suggest that the dorsomedial part of the SCN is more important in regulation of the circadian rhythm of SCN neuronal activity than the ventrolateral.
TL;DR: The F plasmid of Escherichia coli was used to study the genetic background of the control circuit in the bacteria that co-ordinates DNA replication and cell division of the host cells as discussed by the authors.