Institution
Kyushu University
Education•Fukuoka, Japan•
About: Kyushu University is a education organization based out in Fukuoka, Japan. It is known for research contribution in the topics: Population & Catalysis. The organization has 68284 authors who have published 135190 publications receiving 3055928 citations. The organization is also known as: Kyūshū Daigaku.
Topics: Population, Catalysis, Cancer, Hydrogen, Transplantation
Papers published on a yearly basis
Papers
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TL;DR: In this paper, a new processing procedure was applied to a cast Mg-9% Al alloy, which involves the sequential application of extrusion and equal-channel angular pressing and is designated EX-ECAP.
344 citations
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TL;DR: In this paper, four types of orthorhombic olivine LiMPO4 (M:Co, Fe, Ni and Mn) were investigated as highvoltage cathode active materials for lithium secondary batteries.
343 citations
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TL;DR: A comprehensive survey of machine learning testing can be found in this article, which covers 138 papers on testing properties (e.g., correctness, robustness, and fairness), testing components (i.e., the data, learning program, and framework), testing workflow, and application scenarios.
Abstract: This paper provides a comprehensive survey of Machine Learning Testing (ML testing) research. It covers 138 papers on testing properties (e.g., correctness, robustness, and fairness), testing components (e.g., the data, learning program, and framework), testing workflow (e.g., test generation and test evaluation), and application scenarios (e.g., autonomous driving, machine translation). The paper also analyses trends concerning datasets, research trends, and research focus, concluding with research challenges and promising research directions in machine learning testing.
343 citations
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TL;DR: It is shown that intravenously injected hepatocyte growth factor stimulates the growth of hepatocytes in mouse liver and protects the integrity of hepatocyte in vivo against hepatitis caused by hepatotoxin, and may prove to be useful as a treatment for liver diseases.
343 citations
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TL;DR: TheTRPC3-selective inhibitor Pyr3 is a powerful tool to study in vivo function of TRPC3, suggesting a pharmaceutical potential of Pyr3 in treatments of TR PC3-related diseases such as cardiac hypertrophy.
Abstract: Canonical transient receptor potential (TRPC) channels control influxes of Ca2+ and other cations that induce diverse cellular processes upon stimulation of plasma membrane receptors coupled to phospholipase C (PLC). Invention of subtype-specific inhibitors for TRPCs is crucial for distinction of respective TRPC channels that play particular physiological roles in native systems. Here, we identify a pyrazole compound (Pyr3), which selectively inhibits TRPC3 channels. Structure-function relationship studies of pyrazole compounds showed that the trichloroacrylic amide group is important for the TRPC3 selectivity of Pyr3. Electrophysiological and photoaffinity labeling experiments reveal a direct action of Pyr3 on the TRPC3 protein. In DT40 B lymphocytes, Pyr3 potently eliminated the Ca2+ influx-dependent PLC translocation to the plasma membrane and late oscillatory phase of B cell receptor-induced Ca2+ response. Moreover, Pyr3 attenuated activation of nuclear factor of activated T cells, a Ca2+-dependent transcription factor, and hypertrophic growth in rat neonatal cardiomyocytes, and in vivo pressure overload-induced cardiac hypertrophy in mice. These findings on important roles of native TRPC3 channels are strikingly consistent with previous genetic studies. Thus, the TRPC3-selective inhibitor Pyr3 is a powerful tool to study in vivo function of TRPC3, suggesting a pharmaceutical potential of Pyr3 in treatments of TRPC3-related diseases such as cardiac hypertrophy.
343 citations
Authors
Showing all 68546 results
Name | H-index | Papers | Citations |
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Tony Hunter | 175 | 593 | 124726 |
Stanley B. Prusiner | 168 | 745 | 97528 |
Yang Yang | 164 | 2704 | 144071 |
Stephen J. Elledge | 162 | 406 | 112878 |
Takashi Taniguchi | 152 | 2141 | 110658 |
Andrew White | 149 | 1494 | 113874 |
Junji Tojo | 135 | 878 | 84615 |
Claude Leroy | 135 | 1170 | 88604 |
Georges Azuelos | 134 | 1294 | 90690 |
Susumu Oda | 133 | 981 | 80832 |
Lucie Gauthier | 132 | 679 | 64794 |
Hiroshi Sakamoto | 131 | 1250 | 85363 |
Frank Caruso | 131 | 641 | 61748 |
Kiyotomo Kawagoe | 131 | 1406 | 90819 |
Kozo Kaibuchi | 129 | 493 | 60461 |