Institution
Kyushu University
Education•Fukuoka, Japan•
About: Kyushu University is a education organization based out in Fukuoka, Japan. It is known for research contribution in the topics: Population & Catalysis. The organization has 68284 authors who have published 135190 publications receiving 3055928 citations. The organization is also known as: Kyūshū Daigaku.
Topics: Population, Catalysis, Cancer, Gene, Hydrogen
Papers published on a yearly basis
Papers
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TL;DR: The results suggest the potential usefulness of HDAC inhibitors for the treatment of a wide variety of human cancers and identify which subtype of class I HDACs are overexpressed in cancers.
Abstract: Histone deacetylase (HDAC) activity is one of the widely used and well-established mechanisms for regulation of various genes in cancer. To identify which subtype of class I HDACs are overexpressed in cancers, we analyzed the expression of class I HDAC isotypes composed of HDAC1, 2, 3 and 8 in several cell lines and human cancer tissues, including cancer of the stomach, esophagus, colon, prostate, breast, ovary, lung, pancreas and thyroid. The results showed that >75% of human cancer tissues and their corresponding non-cancerous epithelium showed high expression of these class I HDACs. However, the immunoreactivity of HDAC8 in both prostatic cancer tissue and non-cancerous prostate glands was lower than that in other cancer tissues. Furthermore, 5-40% of cancer tissues overexpressed class I HDACs, when compared with normal epithelium. The results suggest the potential usefulness of HDAC inhibitors for the treatment of a wide variety of human cancers.
330 citations
TL;DR: Results suggest that Foxo1 is essential to the ability of endothelial cells to respond properly to a high dose of VEGF, thereby playing a critical role in normal vascular development.
330 citations
TL;DR: Observations demonstrate that tyk2 plays only a restricted role in mediating IFNalpha-dependent signaling while being required in mediates IL-12-dependent biological responses.
330 citations
TL;DR: In this article, a search for new resonant and non-resonant high-mass phenomena in dielectron and dimuon fi nal states was conducted using 36 : 1 fb(-1) of proton-proton collision data.
Abstract: A search is conducted for new resonant and non-resonant high-mass phenomena in dielectron and dimuon fi nal states. The search uses 36 : 1 fb(-1) of proton-proton collision data, collected at root ...
329 citations
TL;DR: In this article, a new treatment in terms of an effective stress has been presented for analysis of the characteristics of a superelastic loop, such as the presence or absence of a peak at the yield point and the magnitude of the hysteresis.
329 citations
Authors
Showing all 68546 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Tony Hunter | 175 | 593 | 124726 |
| Stanley B. Prusiner | 168 | 745 | 97528 |
| Yang Yang | 164 | 2704 | 144071 |
| Stephen J. Elledge | 162 | 406 | 112878 |
| Takashi Taniguchi | 152 | 2141 | 110658 |
| Andrew White | 149 | 1494 | 113874 |
| Junji Tojo | 135 | 878 | 84615 |
| Claude Leroy | 135 | 1170 | 88604 |
| Georges Azuelos | 134 | 1294 | 90690 |
| Susumu Oda | 133 | 981 | 80832 |
| Lucie Gauthier | 132 | 679 | 64794 |
| Hiroshi Sakamoto | 131 | 1250 | 85363 |
| Frank Caruso | 131 | 641 | 61748 |
| Kiyotomo Kawagoe | 131 | 1406 | 90819 |
| Kozo Kaibuchi | 129 | 493 | 60461 |