Institution
Kyushu University
Education•Fukuoka, Japan•
About: Kyushu University is a education organization based out in Fukuoka, Japan. It is known for research contribution in the topics: Population & Catalysis. The organization has 68284 authors who have published 135190 publications receiving 3055928 citations. The organization is also known as: Kyūshū Daigaku.
Topics: Population, Catalysis, Cancer, Hydrogen, Transplantation
Papers published on a yearly basis
Papers
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Stanford University1, University of Minnesota2, Medical College of Wisconsin3, Center for International Blood and Marrow Transplant Research4, University of Michigan5, Harvard University6, Fred Hutchinson Cancer Research Center7, University of Wisconsin Hospital and Clinics8, University of Pennsylvania9, Temple University10, Memorial Sloan Kettering Cancer Center11, Karolinska University Hospital12, Vanderbilt University Medical Center13, University of British Columbia14, Kyushu University15, Ottawa Hospital16, Washington University in St. Louis17, Vanderbilt University18, University of Texas MD Anderson Cancer Center19, Alberta Children's Hospital20, Imperial College London21, Duke University22, Gulf Coast Regional Blood Center23, University of Florida24, Florida Hospital Orlando25, Roswell Park Cancer Institute26, Spanish National Research Council27, Mayo Clinic28, Royal Adelaide Hospital29, Nagoya University30, Karolinska Institutet31, Uppsala University32, Emory University33, Columbia University Medical Center34
TL;DR: In patients with cGVHD, nonrelapse mortality has decreased over time, but at 5 years there were no significant differences among different time periods and the mounting need for addressing this major late complication of transplantation in future research is underscores.
311 citations
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TL;DR: Evidence that material surface chemistry can differentially affect monocyte/macrophage/FB GC adhesion and cytokine/chemokine profiles derived from activated macrophages/FBGCs adherent to biomaterial surfaces is presented.
Abstract: Implantation of biomaterial devices results in the well-known foreign body reaction consisting of monocytes, macrophages, and foreign body giant cells (FBGCs) at the material/tissue interface. We continue to address the hypothesis that material surface chemistry modulates the phenotypic expression of these cells. Utilizing our human monocyte culture system, we have used surface-modified polymers displaying hydrophobic, hydrophilic, and/or ionic chemistries to determine the cytokines/chemokines released from biomaterial-adherent macrophages/FBGCs. This study broadens our approach by using proteomic analysis to identify important factors expressed by these cells and further quantifies these molecules with ELISAs. Proteomic profiles changed over time suggesting that the adherent macrophages underwent a phenotypic switch. Macrophage/FBGC-derived proinflammatory cytokines, IL-1beta and IL-6, decreased with time, while the anti-inflammatory cytokine, IL-10, gradually increased with time. Resolution of the inflammatory response was also demonstrated by a decrease in chemoattractant IL-8 and MIP-1beta production with time. Material-dependent macrophage/FBGC activation was analyzed using cytokine/chemokine production and cellular adhesion. Monocyte/macrophage adhesion was similar on all surfaces, except for the hydrophilic/neutral surfaces that showed a significant decrease in cellular density and minimal FBGC formation. Normalizing the ELISA data based on the adherent cell population provided cytokine/chemokine concentrations produced per cell. This analysis showed that although there were fewer cells on the hydrophilic/neutral surface, these adherent cells were further activated to produce significantly greater amounts of each cytokine/chemokine tested than the other surfaces. This study clearly presents evidence that material surface chemistry can differentially affect monocyte/macrophage/FBGC adhesion and cytokine/chemokine profiles derived from activated macrophages/FBGCs adherent to biomaterial surfaces.
310 citations
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TL;DR: This tutorial review will explore the methods by which gold(I) and other d10 and d8 metal centres have been employed to increase structural dimensionality via the formation of metal-metal interactions.
Abstract: Research in the field of supramolecular chemistry has rapidly grown in recent years due to the generation of fascinating structural topologies and their associated physical properties. In order to rationally synthesize such high-dimensionality systems, several different classes of non-covalent intermolecular interactions in the crystal engineering toolbox can be utilized. Among these, attractive metallophilic interactions, such as those observed for d10gold(I), have been increasingly harnessed as a design element to synthesize functional high-dimensional systems. This tutorial review will explore the methods by which gold(I) and other d10 and d8 metal centres have been employed to increase structural dimensionality via the formation of metal–metal interactions. Physical and optical properties associated with metallophilicity-based supramolecular structures will also be highlighted.
310 citations
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TL;DR: Experiments were conducted to evaluate the grain refinement introduced by equal-channel angular pressing (ECAP) in three different Al-3% Mg alloys containing either 2% Sc, 2% Zr or a combination of 2%Sc and Zr as mentioned in this paper, but superplasticity was not achieved in the Al-Mg-Zr alloy due to the onset of rapid grain growth at 573 K.
310 citations
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TL;DR: HGF may play an important role as a paracrine or endocrine mediator through an epithelial-mesenchymal interaction in wound-healing, tissue or organ regeneration, morphogenesis and carcinogenesis.
310 citations
Authors
Showing all 68546 results
Name | H-index | Papers | Citations |
---|---|---|---|
Tony Hunter | 175 | 593 | 124726 |
Stanley B. Prusiner | 168 | 745 | 97528 |
Yang Yang | 164 | 2704 | 144071 |
Stephen J. Elledge | 162 | 406 | 112878 |
Takashi Taniguchi | 152 | 2141 | 110658 |
Andrew White | 149 | 1494 | 113874 |
Junji Tojo | 135 | 878 | 84615 |
Claude Leroy | 135 | 1170 | 88604 |
Georges Azuelos | 134 | 1294 | 90690 |
Susumu Oda | 133 | 981 | 80832 |
Lucie Gauthier | 132 | 679 | 64794 |
Hiroshi Sakamoto | 131 | 1250 | 85363 |
Frank Caruso | 131 | 641 | 61748 |
Kiyotomo Kawagoe | 131 | 1406 | 90819 |
Kozo Kaibuchi | 129 | 493 | 60461 |