scispace - formally typeset
Search or ask a question
Institution

Kyushu University

EducationFukuoka, Japan
About: Kyushu University is a education organization based out in Fukuoka, Japan. It is known for research contribution in the topics: Population & Catalysis. The organization has 68284 authors who have published 135190 publications receiving 3055928 citations. The organization is also known as: Kyūshū Daigaku.


Papers
More filters
Journal ArticleDOI
TL;DR: Findings suggest that a region between a mercurialsensitive site and the rotenone-sensitive site of the respiratory-chain NADH dehydrogenase is largely responsible for the NADH- and NADPH-dependent O(2) (-) production by the mitochondrial inner membranes.
Abstract: 1. Both NADH and NADPH supported the oxidation of adrenaline to adrenochrome in bovine heart submitochondrial particles. The reaction was completely inhibited in the presence of superoxide dismutase, suggesting that superoxide anions (O2−) are responsible for the oxidation. The optimal pH of the reaction with NADPH was at pH7.5, whereas that with NADH was at pH9.0. The reaction was inhibited by treatment of the preparation with p-hydroxymercuribenzoate and stimulated by treatment with rotenone. Antimycin A and cyanide stimulated the reaction to the same extent as rotenone. The NADPH-dependent reaction was inhibited by inorganic salts at high concentrations, whereas the NADH-dependent reaction was stimulated. 2. Production of O2− by NADH–ubiquinone reductase preparation (Complex I) with NADH or NADPH as an electron donor was assayed by measuring the formation of adrenochrome or the reduction of acetylated cytochrome c which does not react with the respiratory-chain components. p-Hydroxymercuribenzoate inhibited the reaction and rotenone stimulated the reaction. The effects of pH and inorganic salts at high concentrations on the NADH- and NADPH-dependent reactions of Complex I were essentially similar to those on the reactions of submitochondrial particles. 3. These findings suggest that a region between a mercurialsensitive site and the rotenone-sensitive site of the respiratory-chain NADH dehydrogenase is largely responsible for the NADH- and NADPH-dependent O2− production by the mitochondrial inner membranes.

296 citations

Journal ArticleDOI
TL;DR: In this article, an integral structure in orbifold quantum cohomology associated to the K-group and the Γ ˆ-class was introduced. But the integral structure was not shown to match with the natural integral structure for the Landau-Ginzburg model under mirror symmetry.

296 citations

Journal ArticleDOI
TL;DR: Results indicate that increased levels of trienoic fatty acids in genetically engineered plants enhance cold tolerance and are thought to protect plant cells against cold damage.
Abstract: The increased production of trienoic fatty acids, hexadecatrienoic (16:3) and linolenic (18:3) acids, is a response connected with cold acclimation of higher plants and is thought to protect plant cells against cold damage. Transgenic tobacco (Nicotiana tabacum cv SR1) plants that contain increased levels of 16:3 and 18:3 fatty acids, and correspondingly decreased levels of their precursors, hexadecadienoic and linoleic acids, were engineered by introduction of a chloroplast [omega]-3 fatty acid desaturase gene (the fad7 gene) isolated from Arabidopsis thaliana. When exposed to 1[deg]C for 7 d and then cultured at 25[deg]C, the suppression of leaf growth observed in the wild-type plants was significantly alleviated in the transgenic plants with the fad7 gene. The low-temperature- induced chlorosis was also much reduced in the plants transformed with the fad7 gene. These results indicate that increased levels of trienoic fatty acids in genetically engineered plants enhance cold tolerance.

296 citations

Journal ArticleDOI
TL;DR: It is proposed that the order of expression of key transcription factors is critical for their interplay to selectively drive lineage specification programs, by which stem cells could generate multiple lineage cells in a hierarchical manner.
Abstract: The mechanism of lineage specification in multipotent stem cells has not been fully understood. We recently isolated progenitors with the eosinophil, basophil, or mast cell lineage potential, all of which originate from granulocyte/monocyte progenitors (GMPs). By using these prospectively purified progenitors, we show here that the expression timing of GATA-2 and CCAAT enhancer-binding protein α (C/EBPα) can differentially control their lineage commitment. The expression of GATA-2 instructed C/EBPα-expressing GMPs to commit exclusively into the eosinophil lineage, while it induced basophil and/or mast cell lineage commitment if C/EBPα was suppressed at the GMP stage. Furthermore, simply by switching the order of C/EBPα and GATA-2 transduction, even lymphoid-committed progenitors recaptured these developmental processes to be reprogrammed into each of these lineages. We propose that the order of expression of key transcription factors is critical for their interplay to selectively drive lineage specification programs, by which stem cells could generate multiple lineage cells in a hierarchical manner.

296 citations

Journal ArticleDOI
26 Oct 1995-Nature
TL;DR: In this article, the authors report results obtained from drilling a series of holes into an actively forming sulphide deposit on the Mid-Atlantic Ridge, and demonstrate the importance of anhydrite in the growth of massive sulphide deposits, despite its absence in those preserved on land.
Abstract: THE hydrothermal circulation of sea water through permeable ocean crust results in rock–water interactions that lead to the formation of massive sulphide deposits. These are the modern analogues of many ancient ophiolite-hosted deposits1–4, such as those exposed in Cyprus. Here we report results obtained from drilling a series of holes into an actively forming sulphide deposit on the Mid-Atlantic Ridge. A complex assemblage of sulphide–anhydrite–silica breccias provides striking evidence that such hydrothermal mounds do not grow simply by the accumulation of sulphides on the sea floor. Indeed, the deposit grows largely as an in situ breccia pile, as successive episodes of hydrothermal activity each form new hydrothermal precipitates and cement earlier deposits. During inactive periods, the collapse of sulphide chimneys, dissolution of anhydrite, and disruption by faulting cause brecciation of the deposit. The abundance of anhydrite beneath the present region of focused hydrothermal venting reflects the high temperatures ( > 150 °C) currently maintained within the mound, and implies substantial entrainment of cold sea water into the interior of the deposit. These observations demonstrate the important role of anhydrite in the growth of massive sulphide deposits, despite its absence in those preserved on land.

296 citations


Authors

Showing all 68546 results

NameH-indexPapersCitations
Tony Hunter175593124726
Stanley B. Prusiner16874597528
Yang Yang1642704144071
Stephen J. Elledge162406112878
Takashi Taniguchi1522141110658
Andrew White1491494113874
Junji Tojo13587884615
Claude Leroy135117088604
Georges Azuelos134129490690
Susumu Oda13398180832
Lucie Gauthier13267964794
Hiroshi Sakamoto131125085363
Frank Caruso13164161748
Kiyotomo Kawagoe131140690819
Kozo Kaibuchi12949360461
Network Information
Related Institutions (5)
Hiroshima University
69.2K papers, 1.4M citations

96% related

Hokkaido University
115.4K papers, 2.6M citations

95% related

Nagoya University
128.2K papers, 3.2M citations

95% related

Kyoto University
217.2K papers, 6.5M citations

95% related

University of Tsukuba
79.4K papers, 1.9M citations

95% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023137
2022479
20214,870
20205,014
20194,902
20184,570