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Institution

Kyushu University

EducationFukuoka, Japan
About: Kyushu University is a education organization based out in Fukuoka, Japan. It is known for research contribution in the topics: Population & Catalysis. The organization has 68284 authors who have published 135190 publications receiving 3055928 citations. The organization is also known as: Kyūshū Daigaku.


Papers
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Journal ArticleDOI
TL;DR: It is shown that CHIP is a mammalian E4-like molecule that positively regulates Parkin E3 activity and enhanced the ability of Parkin to inhibit cell death induced by Pael-R.

469 citations

Journal ArticleDOI
TL;DR: The p16INK4a /Rb-pathway also cooperates with mitogenic signals to induce elevated intracellular levels of reactive oxygen species (ROS), thereby activating protein kinase Cδ (PKCδ) in human senescent cells, uncover an unexpected role for the p16ink4a–Rb pathway and provide a new insight into how senescent cell-cycle arrest is enforced in human cells.
Abstract: The p16(INK4a) cyclin-dependent kinase inhibitor has a key role in establishing stable G1 cell-cycle arrest through activating the retinoblastoma (Rb) tumour suppressor protein pRb in cellular senescence. Here, we show that the p16(INK4a) /Rb-pathway also cooperates with mitogenic signals to induce elevated intracellular levels of reactive oxygen species (ROS), thereby activating protein kinase Cdelta (PKCdelta) in human senescent cells. Importantly, once activated by ROS, PKCdelta promotes further generation of ROS, thus establishing a positive feedback loop to sustain ROS-PKCdelta signalling. Sustained activation of ROS-PKCdelta signalling irreversibly blocks cytokinesis, at least partly through reducing the level of WARTS (also known as LATS1), a mitotic exit network (MEN) kinase required for cytokinesis, in human senescent cells. This irreversible cytokinetic block is likely to act as a second barrier to cellular immortalization ensuring stable cell-cycle arrest in human senescent cells. These results uncover an unexpected role for the p16(INK4a)-Rb pathway and provide a new insight into how senescent cell-cycle arrest is enforced in human cells.

469 citations

Journal ArticleDOI
TL;DR: Organic light-emitting diodes with these benzophenone derivatives doped in the emissive layer can generate electroluminescence ranging from blue to orange-red and white, with maximum external quantum efficiencies of up to 14.3%.
Abstract: Butterfly-shaped luminescent benzophenone derivatives with small energy gaps between their singlet and triplet excited states are used to achieve efficient full-color delayed fluorescence. Organic light-emitting diodes (OLEDs) with these benzophenone derivatives doped in the emissive layer can generate electroluminescence ranging from blue to orange-red and white, with maximum external quantum efficiencies of up to 14.3%. Triplet excitons are efficiently harvested through delayed fluorescence channels.

468 citations

Journal Article
TL;DR: The cDNA of a new ATP binding cassette superfamily that was specifically enhanced in a cisplatin-resistant human head and neck cancer KB cell line was isolated and a human clone homologous to rat canalicular multispecific organic anion transporter (cMOAT) was found and designated human cMOAT.
Abstract: By targeting the ATP binding conserved domain in three ATP binding cassette superfamily proteins (P-glycoprotein, multidrug resistance protein, and cystic fibrosis transmembrane regulator), we isolated the cDNA of a new ATP binding cassette superfamily that was specifically enhanced in a cisplatin-resistant human head and neck cancer KB cell line. A human clone homologous to rat canalicular multispecific organic anion transporter (cMOAT) was found and designated human cMOAT. Fluorescence in situ hybridization demonstrated the chromosomal locus of the gene on chromosome 10q24. The human cMOAT cDNA hybridized a 6.5-kb mRNA that was expressed 4- to 6-fold higher by three cisplatin-resistant cell lines derived from various human tumors exhibiting decreased drug accumulation. Human cMOAT may function as a cellular cisplatin transporter.

467 citations

Journal ArticleDOI
12 Nov 1997-Langmuir
TL;DR: In this paper, an alternating layer-by-layer assembly of colloidal SiO2 particles with polycations has been investigated by quartz crystal microbalance (QCM), scanning electron microscopy, and atomic force microscopy (AFM).
Abstract: Alternate layer-by-layer assembly of colloidal SiO2 particles with polycations has been investigated by quartz crystal microbalance (QCM), scanning electron microscopy (SEM), and atomic force microscopy (AFM). QCM measurement confirmed the high regularity and reproducibility of the assembling process that depends on particle concentration, particle size, and ionic strength. The individual adsorption step was completed within 15 s. The thickness of adsorbed layers increased with increasing SiO2 concentrations at the three particle sizes used (45, 25, and 78 nm in diameter), unlike the case for other polyion assemblies. It also increased with increasing ionic strength of aqueous SiO2 dispersions. According to SEM observation, the assembled film possessed surprisingly flat surfaces at optimized ionic strengths. AFM observation revealed that SiO2 particles were not closely packed. The neutralization ratio of SiO2 and PDDA was estimated by turbidity measurement. Comparison of turbidity and QCM data indicated t...

467 citations


Authors

Showing all 68546 results

NameH-indexPapersCitations
Tony Hunter175593124726
Stanley B. Prusiner16874597528
Yang Yang1642704144071
Stephen J. Elledge162406112878
Takashi Taniguchi1522141110658
Andrew White1491494113874
Junji Tojo13587884615
Claude Leroy135117088604
Georges Azuelos134129490690
Susumu Oda13398180832
Lucie Gauthier13267964794
Hiroshi Sakamoto131125085363
Frank Caruso13164161748
Kiyotomo Kawagoe131140690819
Kozo Kaibuchi12949360461
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023137
2022479
20214,870
20205,014
20194,902
20184,570