Showing papers by "La Trobe University published in 2008"

Interaction, growth, and ordering of epitaxial graphene on SiC{0001} surfaces: A comparative photoelectron spectroscopy study

Abstract: Thermally induced growth of graphene on the two polar surfaces of $6H\text{\ensuremath{-}}\mathrm{Si}\mathrm{C}$ is investigated with emphasis on the initial stages of growth and interface structure. The experimental methods employed are angle-resolved valence band photoelectron spectroscopy, soft x-ray induced core-level spectroscopy, and low-energy electron diffraction. On the Si-terminated (0001) surface, the $(6\sqrt{3}\ifmmode\times\else\texttimes\fi{}6\sqrt{3})R30\ifmmode^\circ\else\textdegree\fi{}$ reconstruction is the precursor of the growth of graphene and it persists at the interface upon the growth of few layer graphene (FLG). The $(6\sqrt{3}\ifmmode\times\else\texttimes\fi{}6\sqrt{3})R30\ifmmode^\circ\else\textdegree\fi{}$ structure is a carbon layer with graphene-like atomic arrangement covalently bonded to the substrate where it is responsible for the azimuthal ordering of FLG on SiC(0001). In contrast, the interaction between graphene and the C-terminated $(000\overline{1})$ surface is much weaker, which accounts for the low degree of order of FLG on this surface. A model for the growth of FLG on SiC{0001} is developed, wherein each new graphene layer is formed at the bottom of the existing stack rather than on its top. This model yields, in conjunction with the differences in the interfacial bonding strength, a natural explanation for the different degrees of azimuthal order observed for FLG on the two surfaces.

Person-centred care of people with severe Alzheimer's disease: current status and ways forward

Abstract: When caring for people with severe Alzheimer's disease (AD), the concept of the person being central is increasingly advocated in clinical practice and academia as an approach to deliver high-quality care. The aim of person-centred care, which emanates from phenomological perspectives on AD, is to acknowledge the personhood of people with AD in all aspects of their care. It generally includes the recognition that the personality of the person with AD is increasingly concealed rather than lost; personalisation of the person's care and their environment; offering shared decision-making; interpretation of behaviour from the viewpoint of the person; and prioritising the relationship as much as the care tasks. However, questions remain about how to provide, measure, and explore clinical outcomes of person-centred care. In this Review, we summarise the current knowledge about person-centred care for people with severe AD and highlight the areas in need of further research.

Normative values for the Foot Posture Index.

Abstract: The Foot Posture Index (FPI) is a validated method for quantifying standing foot posture, and is being used in a variety of clinical settings. There have however, been no normative data available to date for comparison and reference. This study aimed to establish normative FPI reference values. Studies reporting FPI data were identified by searching online databases. Nine authors contributed anonymised versions of their original datasets comprising 1648 individual observations. The datasets included information relating to centre, age, gender, pathology (if relevant), FPI scores and body mass index (BMI) where available. FPI total scores were transformed to interval logit scores as per the Rasch model and normal ranges were defined. Comparisons between groups employed t-tests or ANOVA models as appropriate and data were explored descriptively and graphically. The main analysis based on a normal healthy population (n = 619) confirmed that a slightly pronated foot posture is the normal position at rest (mean back transformed FPI raw score = +4). A 'U' shaped relationship existed for age, with minors and older adults exhibiting significantly higher FPI scores than the general adult population (F = 51.07, p < 0.001). There was no difference between the FPI scores of males and females (2.3 versus 2.5; t = -1.44, p = 0.149). No relationship was found between the FPI and BMI. Systematic differences from the adult normals were confirmed in patients with neurogenic and idiopathic cavus (F = 216.981, p < 0.001), indicating some sensitivity of the instrument to detect a posturally pathological population. A set of population norms for children, adults and older people have been derived from a large sample. Foot posture is related to age and the presence of pathology, but not influenced by gender or BMI. The normative values identified may assist in classifying foot type for the purpose of research and clinical decision making.

Science with ASKAP: The Australian square-kilometre-array pathfinder

Abstract: The future of cm and m-wave astronomy lies with the Square Kilometre Array (SKA), a telescope under development by a consortium of 17 countries. The SKA will be 50 times more sensitive than any existing radio facility. A majority of the key science for the SKA will be addressed through large-area imaging of the Universe at frequencies from 300 MHz to a few GHz. The Australian SKA Pathfinder (ASKAP) is aimed squarely in this frequency range, and achieves instantaneous wide-area imaging through the development and deployment of phase-array feed systems on parabolic reflectors. This large field-of-view makes ASKAP an unprecedented synoptic telescope poised to achieve substantial advances in SKA key science. The central core of ASKAP will be located at the Murchison Radio Observatory in inland Western Australia, one of the most radio-quiet locations on the Earth and one of the sites selected by the international community as a potential location for the SKA. Following an introductory description of ASKAP, this document contains 7 chapters describing specific science programmes for ASKAP. In summary, the goals of these programmes are as follows: The combination of location, technological innovation and scientific program will ensure that ASKAP will be a world-leading radio astronomy facility, closely aligned with the scientific and technical direction of the SKA. A brief summary chapter emphasizes the point, and considers discovery space.

A new class of energy-preserving numerical integration methods

Abstract: The first ever energy-preserving B-series numerical integration method for (ordinary) differential equations is presented and applied to several Hamiltonian systems. Related novel Lie algebraic results are also discussed.

Replication and p Intervals: p Values Predict the Future Only Vaguely, but Confidence Intervals Do Much Better:

Abstract: Replication is fundamental to science, so statistical analysis should give information about replication. Because p values dominate statistical analysis in psychology, it is important to ask what p says about replication. The answer to this question is "Surprisingly little." In one simulation of 25 repetitions of a typical experiment, p varied from .44. Remarkably, the interval-termed a p interval-is this wide however large the sample size. p is so unreliable and gives such dramatically vague information that it is a poor basis for inference. Confidence intervals, however, give much better information about replication. Researchers should minimize the role of p by using confidence intervals and model-fitting techniques and by adopting meta-analytic thinking.

Drawing the Global Colour Line: White Men's Countries and the International Challenge of Racial Equality

Abstract: Introduction Part I. Modern Mobilities: 1. The coming man: Chinese migration to the Goldfields Part II. Discursive Frameworks: 2. James Bryce's America and the negro problem 3. Charles Pearson's prophecy: 'The day will come' 4. Theodore Roosevelt: re-asserting racial vigour 5. Imperial brotherhood or white: Gandhi in South Africa Part III. Transnational Solidarities: 6. White Australia points the way 7. Defending the Pacific slope 8. White ties across the ocean: the Pacific Tour of the US Fleet 9. The Union of South Africa: white men reconcile Part IV. Challenge and Consolidation: 10. International conferences: enmity and amity 11. Japanese alienation and imperial ambition 12. Racial equality? Paris Peace Conference, 1919 13. 'Segregation on a Large Scale': immigration restriction, 1920s Part V. Towards Universal Human Rights: 14. Rights without distinction.

Eating disorder behaviors are increasing : findings from two sequential community surveys in South Australia

Abstract: Background: evidence for an increase in the prevalence of eating disorders is inconsistent. Our aim was to determine change in the population point prevalence of eating disorder behaviors over a 10-year period. Methodology/Principal Findings: eating disorder behaviors were assessed in consecutive general population surveys of men and women conducted in 1995 (n = 3001, 72% respondents) and 2005 (n = 3047, 63.1% respondents). Participants were randomly sampled from households in rural and metropolitan South Australia. There was a significant (all p,0.01) and over two-fold increase in the prevalence of binge eating, purging (self-induced vomiting and/or laxative or diuretic misuse) and strict dieting or fasting for weight or shape control among both genders. The most common diagnosis in 2005 was either binge eating disorder or other ‘‘eating disorders not otherwise specified’’ (EDNOS; n = 119, 4.2%). Conclusions/Significance: in this population sample the point prevalence of eating disorder behaviors increased over the past decade. Cases of anorexia nervosa and bulimia nervosa, as currently defined, remain uncommon.

A Very Early Rehabilitation Trial for Stroke (AVERT) Phase II Safety and Feasibility

Abstract: Background and Purpose— Very early rehabilitation, with an emphasis on mobilization, may contribute to improved outcomes after stroke. We hypothesized that a very early rehabilitation protocol would be safe and feasible. Methods— We performed a randomized, controlled trial with blinded outcome assessment. Patients at <24 hours after stroke were recruited from 2 Melbourne metropolitan stroke units. Patients were randomly assigned to receive standard care (SC) or SC plus very early mobilization (VEM) until discharge or 14 days (whichever was sooner). The primary safety outcome was the number of deaths at 3 months. The primary feasibility outcome was a higher “dose” of mobilization achieved in VEM. Secondary safety outcomes included adverse events (including falls and early neurologic deterioration), compliance with physiologic monitoring criteria, and patient fatigue after interventions. Secondary feasibility outcomes included “contamination” of standard care. Results— Overall, 18% of patients screened were suitable for recruitment. Seventy-one patients were recruited and randomized, with 2 dropouts by 12 months. The majority experienced ischemic strokes (87%). The group mean±SD age was 74.7±12.5 years, and 58% (n=41) had a National Institutes of Health Stroke Scale score >7. There was no significant difference in the number of deaths between groups (SC, 3 of 33; VEM, 8 of 38; P =0.20). Almost all deaths occurred in patients with severe stroke. Secondary safety outcomes were similar between groups. The intervention protocol was successfully delivered, achieving VEM dose targets (double SC, P =0.003) and faster time to first mobilization ( P <0.001). Conclusions— VEM of patients within 24 hours of acute stroke appears safe and feasible. Intervention efficacy and cost-effectiveness are currently being tested in a large randomized, controlled trial.

Intellectual Capital : Definitions, Categorization and Reporting Models

Abstract: Purpose – The purpose of this paper is to develop a conceptual framework that can be used to formalise a reporting model for intellectual capital (IC).Design/methodology/approach – This paper proposes a reporting model with a formal definition and classifications of IC to analyse and report on the IC generated by a firm.Findings – This paper demonstrates that the field is maturing to one in which it is possible to analyse existing definitions and classifications of IC to construct a formal body of items that can be considered as IC for use in the study and application of IC.Practical implications – The paper presents a formal reporting model which can be used generally in the analysis of the IC generated from the production process of a firm.Originality/value – This study examines the characteristics of items that can be considered as IC in order to provide a formal classification system of IC that can be instilled in a reporting system which can be used generally in any organization that involves the use...

Prevalence and correlates of foot pain in a population-based study: the North West Adelaide health study.

Abstract: Background Few population-based studies have examined the prevalence of foot pain in the general community. The aims of this study were therefore to determine the prevalence, correlates and impact of foot pain in a population-based sample of people aged 18 years and over living in the northwest region of Adelaide, South Australia.

Men, Sex, and Homosociality How Bonds between Men Shape Their Sexual Relations with Women

Abstract: Male-male social bonds have a powerful influence on the sexual relations of some young heterosexual men. Qualitative analysis among young men aged eighteen to twenty-six in Canberra, Australia, documents the homosocial organization of men's heterosexual relations. Homosociality organizes men's sociosexual relations in at least four ways. For some of these young men, male-male friendships take priority over male-female relations, and platonic friendships with women are dangerously feminizing. Sexual activity is a key path to masculine status, and other men are the audience, always imagined and sometimes real, for one's sexual activities. Heterosexual sex itself can be the medium through which male bonding is enacted. Last, men's sexual storytelling is shaped by homosocial masculine cultures. While these patterns were evident particularly among young men in the highly homosocial culture of a military academy, their presence also among other groups suggests the wider influence of homosociality on men's sexual and social relations.

Keyhole coherent diffractive imaging

Abstract: A powerful coherent diffractive X-ray imaging technique could enable next generation synchrotrons and free-electron lasers to study much larger samples than previously thought possible.

Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans

Abstract: MDM2, a ubiquitin E3-ligase of the RING family, has a key role in regulating p53 abundance. During normal non-stress conditions p53 is targeted for degradation by MDM2. MDM2 can also target itself and MDMX for degradation. MDMX is closely related to MDM2 but the RING domain of MDMX does not possess intrinsic E3-ligase activity. Instead, MDMX regulates p53 abundance by modulating the levels and activity of MDM2. Dimerization, mediated by the conserved C-terminal RING domains of both MDM2 and MDMX, is critical to this activity. Here we report the crystal structure of the MDM2/MDMX RING domain heterodimer and map residues required for functional interaction with the E2 (UbcH5b). In both MDM2 and MDMX residues C-terminal to the RING domain have a key role in dimer formation. In addition we show that these residues are part of an extended surface that is essential for ubiquitylation in trans. This study provides a molecular basis for understanding how heterodimer formation leads to stabilization of MDM2, yet degradation of p53, and suggests novel targets for therapeutic intervention.

Environment-friendly Tourists: What Do We Really Know About Them?

Abstract: Sustainable tourism and ecotourism have now been researched in depth for some years. This paper highlights that researchers still have only a limited understanding of what tourist behaviour can be considered as sustainable, and little consensus about who environment-friendly tourists (EFTs) actually are. This study reviews theoretical and empirical studies by tourism researchers, and explores work done on environment-friendly behaviour in other disciplines. Results indicate that operationalisations of EFTs are inconsistent and, at times, do not ensure that EFTs are actually studied, thus jeopardising the quality of cumulative knowledge on this critical issue. There is little insight into who EFTs are. Suggestions for future work are made, which would develop more reliable and generalisable insights into EFT profiles.

IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis.

Abstract: The covalent attachment of ubiquitin to target proteins influences various cellular processes, including DNA repair, NF-kappaB signalling and cell survival. The most common mode of regulation by ubiquitin-conjugation involves specialized ubiquitin-binding proteins that bind to ubiquitylated proteins and link them to downstream biochemical processes. Unravelling how the ubiquitin-message is recognized is essential because aberrant ubiquitin-mediated signalling contributes to tumour formation. Recent evidence indicates that inhibitor of apoptosis (IAP) proteins are frequently overexpressed in cancer and their expression level is implicated in contributing to tumorigenesis, chemoresistance, disease progression and poor patient-survival. Here, we have identified an evolutionarily conserved ubiquitin-associated (UBA) domain in IAPs, which enables them to bind to Lys 63-linked polyubiquitin. We found that the UBA domain is essential for the oncogenic potential of cIAP1, to maintain endothelial cell survival and to protect cells from TNF-alpha-induced apoptosis. Moreover, the UBA domain is required for XIAP and cIAP2-MALT1 to activate NF-kappaB. Our data suggest that the UBA domain of cIAP2-MALT1 stimulates NF-kappaB signalling by binding to polyubiquitylated NEMO. Significantly, 98% of all cIAP2-MALT1 fusion proteins retain the UBA domain, suggesting that ubiquitin-binding contributes to the oncogenic potential of cIAP2-MALT1 in MALT lymphoma. Our data identify IAPs as ubiquitin-binding proteins that contribute to ubiquitin-mediated cell survival, NF-kappaB signalling and oncogenesis.

Risk to Researchers in Qualitative Research on Sensitive Topics: Issues and Strategies

Abstract: Traditionally, risk assessments in research have been limited to examining the risks to the research participants. Although doing so is appropriate and important, there is growing recognition that undertaking research can pose risks to researchers as well. A grounded theory study involving a range of researchers who had undertaken qualitative health research on a sensitive topic was completed. Analysis of the in-depth, face-to-face unstructured individual interviews with 30 Australian public health researchers provided evidence that researchers do confront a number of physical and emotional risks when undertaking research. Training, preparation, and supervision must be taken into account so that the risk to researchers can be minimized. Researchers need to consider occupational health and safety issues in designing research projects that deal with physical and emotional risks. Recommendations for professional supervision, policy development, and minimum training standards for researchers are provided.

Islamic banking and finance: on its way to globalization

Abstract: Purpose – The main objective of this paper is to highlight the unprecedented growth of Islamic banking and finance in the contemporary finance world. It captures the advancements of Islamic banking and finance industry across the tools, systems, sectors, markets and over 75 countries from Africa, Asia, Europe and North America.Design/methodology/approach – The paper deals with the paradigm of Islamic banking and finance. It constitutes a general review that bears special features, facts and figures over the recent developments of Islamic banking and finance across the globe. It takes stock of the growing institutional and infrastructure support for the Islamic banking and finance system in Muslim countries and Western financial markets.Findings – The findings of the paper hold that Islamic banking and finance industry has been making breakthrough improvements to become a truly viable and competitive alternative to conventional systems at the global level. Islamic banking and finance institutions have acqu...

How to situate cognition: Letting nature take its course

Abstract: 1. The Situation in Cognition The situated cognition movement in the cognitive sciences, like those sciences themselves, is a loose-knit family of approaches to understanding the mind and cognition. While it has both philosophical and psychological antecedents in thought stretching back over the last century (see Gallagher, this volume, Clancey, this volume,), it has developed primarily since the late 1970s as an alternative to, or a modification of, the then predominant paradigms for exploring the mind within the cognitive sciences. For this reason it has been common to characterize situated cognition in terms of what it is not, a cluster of "anti-isms". Situated cognition has thus been described as opposed to Platonism, Cartesianism, individualism, representationalism, and even

TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1–TRAF2 complex to sensitize tumor cells to TNFα

Abstract: Synthetic inhibitor of apoptosis (IAP) antagonists induce degradation of IAP proteins such as cellular IAP1 (cIAP1), activate nuclear factor κB (NF-κB) signaling, and sensitize cells to tumor necrosis factor α (TNFα). The physiological relevance of these discoveries to cIAP1 function remains undetermined. We show that upon ligand binding, the TNF superfamily receptor FN14 recruits a cIAP1–Tnf receptor-associated factor 2 (TRAF2) complex. Unlike IAP antagonists that cause rapid proteasomal degradation of cIAP1, signaling by FN14 promotes the lysosomal degradation of cIAP1–TRAF2 in a cIAP1-dependent manner. TNF-like weak inducer of apoptosis (TWEAK)/FN14 signaling nevertheless promotes the same noncanonical NF-κB signaling elicited by IAP antagonists and, in sensitive cells, the same autocrine TNFα-induced death occurs. TWEAK-induced loss of the cIAP1–TRAF2 complex sensitizes immortalized and minimally passaged tumor cells to TNFα-induced death, whereas primary cells remain resistant. Conversely, cIAP1–TRAF2 complex overexpression limits FN14 signaling and protects tumor cells from TWEAK-induced TNFα sensitization. Lysosomal degradation of cIAP1–TRAF2 by TWEAK/FN14 therefore critically alters the balance of life/death signals emanating from TNF-R1 in immortalized cells.

An experimental clinical trial of a cognitive-behavior therapy package for chronic stuttering.

Abstract: Purpose The aims of the present study were to (a) examine the rate of social phobia among adults who stutter, (b) study the effects of speech restructuring treatment on social anxiety, and (c) stud...

Catering for the needs of fauna in fire management: science or just wishful thinking?

Abstract: Ecological fire management in Australia is often built on an assumption that meeting the needs of plant species will automatically meet the needs of animal species. However, the scarcity of ecological data on the needs of fauna in relation to fire undermines the confidence managers should place in current popular frameworks for planning ecological burning. Such frameworks are built almost entirely around the goal of maintaining plant community diversity. They provide little guidance to managers regarding the characteristics of desirable 'mosaics' (e.g. patch size, connectivity or composition of age-since-burnt classes) or the timing of fires in relation to faunal population trends linked to other cycles (e.g. El Nino events). Claims by agencies of adopting an adaptive management approach ('learning by doing') to cope with a dearth of knowledge are credible only if monitoring and evaluation are carried out and future actions are modified in light of new evidence. Much monitoring of fauna is of such a small scale and short duration that the statistical likelihood of detecting a positive or negative effect of the management regime is minute. Such shortcomings will only be overcome through broad-scale and/or long-term studies of fauna. The funding for such research is unlikely to be forthcoming if fire ecologists and land managers convey the impression that the current data are adequate for the implementation of the current planning frameworks.

Corporate Governance Structure and the Valuation of Australian Firms: Is There Value in Ticking the Boxes?

Abstract: This paper provides an investigation of the valuation and agency consequences of corporate governance policy. This is achieved by examining variation in voluntary adoption by Australian listed firms, during the period from 1992 to 2002, of corporate governance frameworks representative of the governance code of practice introduced by the Australian Stock Exchange in 2003. The findings indicate benefits for firms from overall corporate governance structuring, but not in isolation, in line with the requirements now in place, and a significant role played by institutional and external shareholders as alternative agency mechanisms. Corporate governance structure is found to be important, however, the likely impact of disclosure of governance practice or compliance on valuation is less clear.