Institution
La Trobe University
Education•Melbourne, Victoria, Australia•
About: La Trobe University is a education organization based out in Melbourne, Victoria, Australia. It is known for research contribution in the topics: Population & Health care. The organization has 13370 authors who have published 41291 publications receiving 1138269 citations. The organization is also known as: LaTrobe University & LTU.
Papers published on a yearly basis
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TL;DR: It is argued that the results reflect developmental factors and that claims for an autism specific problem in these kinds of social/cognitive processing may need further exploration.
Abstract: Autistic children, pair matched on chronological and verbal mental age with control children, were given Hobson's task of recognition of emotions and Baron-Cohen's False Belief tasks to assess the replicability of their findings of deficits in understanding of feeling and mental states in autism. There were no group differences on the emotion tasks and performance was related to chronological and verbal mental age. An autism specific deficit was shown in only one of the false belief conditions and again performance was related to verbal comprehension ability. There was some consistency within the group in responses across the two kinds of tasks. Parent reported social behaviour and experience in the autistic children was only weakly related to the ability to pass the tasks. It is argued that the results reflect developmental factors and that claims for an autism specific problem in these kinds of social/cognitive processing may need further exploration.
264 citations
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VU University Amsterdam1, University of Leeds2, University of Duisburg-Essen3, University of Texas MD Anderson Cancer Center4, Semmelweis University5, Austrian Academy of Sciences6, Duke University7, Harvard University8, Broad Institute9, Case Western Reserve University10, Medical University of Vienna11, Northwestern University12, University of Liverpool13, University of Connecticut Health Center14, St James's University Hospital15, James Cancer Hospital16, Yale University17, Brigham and Women's Hospital18, Medical College of Wisconsin19, University of California, San Francisco20, German Cancer Research Center21, Erasmus University Rotterdam22, University of Melbourne23, La Trobe University24, National Institutes of Health25, Laval University26, Columbia University Medical Center27, University of Sydney28, Henry Ford Health System29, University of New South Wales30, Samsung Medical Center31, The Chinese University of Hong Kong32, University of Luxembourg33, University of Colorado Denver34, Seoul National University Hospital35, Columbia University36, University of Düsseldorf37, University Hospitals of Cleveland38, Hospital for Sick Children39, University of Tübingen40, Emory University41, University of Birmingham42, University of Zurich43, University Health Network44
TL;DR: The results suggest that the strongest selective pressures occur during early glioma development and that current therapies shape this evolution in a largely stochastic manner.
Abstract: The evolutionary processes that drive universal therapeutic resistance in adult patients with diffuse glioma remain unclear1,2. Here we analysed temporally separated DNA-sequencing data and matched clinical annotation from 222 adult patients with glioma. By analysing mutations and copy numbers across the three major subtypes of diffuse glioma, we found that driver genes detected at the initial stage of disease were retained at recurrence, whereas there was little evidence of recurrence-specific gene alterations. Treatment with alkylating agents resulted in a hypermutator phenotype at different rates across the glioma subtypes, and hypermutation was not associated with differences in overall survival. Acquired aneuploidy was frequently detected in recurrent gliomas and was characterized by IDH mutation but without co-deletion of chromosome arms 1p/19q, and further converged with acquired alterations in the cell cycle and poor outcomes. The clonal architecture of each tumour remained similar over time, but the presence of subclonal selection was associated with decreased survival. Finally, there were no differences in the levels of immunoediting between initial and recurrent gliomas. Collectively, our results suggest that the strongest selective pressures occur during early glioma development and that current therapies shape this evolution in a largely stochastic manner.
264 citations
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TL;DR: Given the limited evidence, the use of CIMT, modified CimT and Forced use should be considered experimental in children with hemiplegic cerebral palsy and further research using adequately powered RCTs, rigorous methodology and valid, reliable outcome measures is essential.
Abstract: Background: Constraint-induced movement therapy (CIMT) is emerging as a treatment approach for children with hemiplegic cerebral palsy. It aims to increase spontaneous use of the affected upper limb and limit the effects of learned non-use. This review evaluates the effectiveness of CIMT, modified CIMT or Forced use in the treatment of children with hemiplegic cerebral palsy.Design and methods: Systematic Cochrane Review. The Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2006, Issue 3), MEDLINE (1966 to August Week 4 2006), CINAHL (1982 to July Week 3 2006), EMBASE (1980 to August 2006), PsychInfo (1985 to August Week 4 2006) and reference lists of all relevant articles were searched. Relevant randomized and controlled clinical trials were systematically reviewed.Results: Three studies met the inclusion criteria. One randomized controlled trial (RCT) showed a trend for positive treatment effect favouring CIMT using the Dissociated Movement subscale of the Quality of Upper ...
263 citations
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TL;DR: The continuum model of tendon pathology, proposed in 2009, synthesised clinical and laboratory-based research to guide treatment choices for the clinical presentations of tendinopathy and may help guide targeted treatments and improved patient outcomes.
Abstract: The pathogenesis of tendinopathy and the primary biological change in the tendon that precipitates pathology have generated several pathoaetiological models in the literature. The continuum model of tendon pathology, proposed in 2009, synthesised clinical and laboratory-based research to guide treatment choices for the clinical presentations of tendinopathy. While the continuum has been cited extensively in the literature, its clinical utility has yet to be fully elucidated. The continuum model proposed a model for staging tendinopathy based on the changes and distribution of disorganisation within the tendon. However, classifying tendinopathy based on structure in what is primarily a pain condition has been challenged. The interplay between structure, pain and function is not yet fully understood, which has partly contributed to the complex clinical picture of tendinopathy. Here we revisit and assess the merit of the continuum model in the context of new evidence. We (1) summarise new evidence in tendinopathy research in the context of the continuum, (2) discuss tendon pain and the relevance of a model based on structure and (3) describe relevant clinical elements (pain, function and structure) to begin to build a better understanding of the condition. Our goal is that the continuum model may help guide targeted treatments and improved patient outcomes.
263 citations
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TL;DR: Re-examines the factor structure of the 12-item GHQ for a large Australian sample of young people and shows that oblique factor rotation better approaches the criterion of simple structure, and allows separate components of the GHQ to be identified and measured using factor scores.
Abstract: This analysis re-examines the factor structure of the 12-item GHQ for a large Australian sample of young people. It shows that oblique factor rotation better approaches the criterion of simple structure, and allows separate components of the GHQ to be identified and measured using factor scores. When the performance of these separate factors is compared with composite Likert scores, it is found that they do not behave uniformly in response to outside variables, both in cross-sectional and longitudinal analyses. These results suggest that there are advantages to be gained by using the multidimensional properties of the GHQ as well as a single severity score. The additional information this yields can provide new insights into the nature of psychiatric impairment within and between samples.
262 citations
Authors
Showing all 13601 results
Name | H-index | Papers | Citations |
---|---|---|---|
Rasmus Nielsen | 135 | 556 | 84898 |
C. N. R. Rao | 133 | 1646 | 86718 |
James Whelan | 128 | 786 | 89180 |
Jacqueline Batley | 119 | 1212 | 68752 |
Eske Willerslev | 115 | 367 | 43039 |
Jonathan E. Shaw | 114 | 629 | 108114 |
Ary A. Hoffmann | 113 | 907 | 55354 |
Mike Clarke | 113 | 1037 | 164328 |
Richard J. Simpson | 113 | 850 | 59378 |
Alan F. Cowman | 111 | 379 | 38240 |
David C. Page | 110 | 509 | 44119 |
Richard Gray | 109 | 808 | 78580 |
David S. Wishart | 108 | 523 | 76652 |
Alan G. Marshall | 107 | 1060 | 46904 |
David A. Williams | 106 | 633 | 42058 |