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Institution

La Trobe University

EducationMelbourne, Victoria, Australia
About: La Trobe University is a education organization based out in Melbourne, Victoria, Australia. It is known for research contribution in the topics: Population & Health care. The organization has 13370 authors who have published 41291 publications receiving 1138269 citations. The organization is also known as: LaTrobe University & LTU.


Papers
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Journal ArticleDOI
TL;DR: It is argued that the results reflect developmental factors and that claims for an autism specific problem in these kinds of social/cognitive processing may need further exploration.
Abstract: Autistic children, pair matched on chronological and verbal mental age with control children, were given Hobson's task of recognition of emotions and Baron-Cohen's False Belief tasks to assess the replicability of their findings of deficits in understanding of feeling and mental states in autism. There were no group differences on the emotion tasks and performance was related to chronological and verbal mental age. An autism specific deficit was shown in only one of the false belief conditions and again performance was related to verbal comprehension ability. There was some consistency within the group in responses across the two kinds of tasks. Parent reported social behaviour and experience in the autistic children was only weakly related to the ability to pass the tasks. It is argued that the results reflect developmental factors and that claims for an autism specific problem in these kinds of social/cognitive processing may need further exploration.

264 citations

Journal ArticleDOI
Floris P. Barthel1, Kevin C. Johnson, Frederick S. Varn, Anzhela D. Moskalik, Georgette Tanner2, Emre Kocakavuk3, Kevin J. Anderson, Olajide Abiola, Kenneth Aldape, Kristin Alfaro4, Donát Alpár5, Donát Alpár6, Samirkumar B. Amin, David M. Ashley7, Pratiti Bandopadhayay8, Pratiti Bandopadhayay9, Jill S. Barnholtz-Sloan10, Rameen Beroukhim8, Rameen Beroukhim9, Christoph Bock6, Christoph Bock11, Priscilla K. Brastianos8, Daniel J. Brat12, Andrew R Brodbelt13, Alexander F. Bruns2, Ketan R. Bulsara14, Aruna Chakrabarty15, Arnab Chakravarti16, Jeffrey H. Chuang14, Elizabeth B. Claus17, Elizabeth B. Claus18, Elizabeth J. Cochran19, Jennifer Connelly19, Joseph F. Costello20, Gaetano Finocchiaro, Michael N. C. Fletcher21, Pim J. French22, Hui K Gan23, Hui K Gan24, Mark R. Gilbert25, Peter Gould26, Matthew R. Grimmer20, Antonio Iavarone27, Azzam Ismail15, Michael D. Jenkinson13, Mustafa Khasraw28, Hoon Kim, Mathilde C.M. Kouwenhoven1, Peter S. LaViolette19, Meihong Li, Peter Lichter21, Keith L. Ligon8, Keith L. Ligon9, Allison Lowman19, Tathiane M. Malta29, Tali Mazor20, Kerrie L. McDonald30, Annette M. Molinaro20, Do-Hyun Nam31, Naema Nayyar8, Ho Keung Ng32, Chew Yee Ngan, Simone P. Niclou33, Johanna M. Niers1, Houtan Noushmehr29, Javad Noorbakhsh, D. Ryan Ormond34, Chul-Kee Park35, Laila M. Poisson29, Raul Rabadan27, Raul Rabadan36, Bernhard Radlwimmer21, Ganesh Rao4, Guido Reifenberger37, Jason K. Sa31, Michael Schuster6, Brian L. Shaw8, Susan C Short2, Peter A. E. Sillevis Smitt22, Andrew E. Sloan10, Andrew E. Sloan38, Marion Smits22, Hiromichi Suzuki39, Ghazaleh Tabatabai40, Erwin G. Van Meir41, Colin Watts42, Michael Weller43, Pieter Wesseling1, Bart A. Westerman1, Georg Widhalm11, Adelheid Woehrer11, W. K. Alfred Yung4, Gelareh Zadeh44, Jason T. Huse4, John de Groot4, Lucy F. Stead2, Roel G.W. Verhaak 
05 Dec 2019-Nature
TL;DR: The results suggest that the strongest selective pressures occur during early glioma development and that current therapies shape this evolution in a largely stochastic manner.
Abstract: The evolutionary processes that drive universal therapeutic resistance in adult patients with diffuse glioma remain unclear1,2. Here we analysed temporally separated DNA-sequencing data and matched clinical annotation from 222 adult patients with glioma. By analysing mutations and copy numbers across the three major subtypes of diffuse glioma, we found that driver genes detected at the initial stage of disease were retained at recurrence, whereas there was little evidence of recurrence-specific gene alterations. Treatment with alkylating agents resulted in a hypermutator phenotype at different rates across the glioma subtypes, and hypermutation was not associated with differences in overall survival. Acquired aneuploidy was frequently detected in recurrent gliomas and was characterized by IDH mutation but without co-deletion of chromosome arms 1p/19q, and further converged with acquired alterations in the cell cycle and poor outcomes. The clonal architecture of each tumour remained similar over time, but the presence of subclonal selection was associated with decreased survival. Finally, there were no differences in the levels of immunoediting between initial and recurrent gliomas. Collectively, our results suggest that the strongest selective pressures occur during early glioma development and that current therapies shape this evolution in a largely stochastic manner.

264 citations

Journal ArticleDOI
TL;DR: Given the limited evidence, the use of CIMT, modified CimT and Forced use should be considered experimental in children with hemiplegic cerebral palsy and further research using adequately powered RCTs, rigorous methodology and valid, reliable outcome measures is essential.
Abstract: Background: Constraint-induced movement therapy (CIMT) is emerging as a treatment approach for children with hemiplegic cerebral palsy. It aims to increase spontaneous use of the affected upper limb and limit the effects of learned non-use. This review evaluates the effectiveness of CIMT, modified CIMT or Forced use in the treatment of children with hemiplegic cerebral palsy.Design and methods: Systematic Cochrane Review. The Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2006, Issue 3), MEDLINE (1966 to August Week 4 2006), CINAHL (1982 to July Week 3 2006), EMBASE (1980 to August 2006), PsychInfo (1985 to August Week 4 2006) and reference lists of all relevant articles were searched. Relevant randomized and controlled clinical trials were systematically reviewed.Results: Three studies met the inclusion criteria. One randomized controlled trial (RCT) showed a trend for positive treatment effect favouring CIMT using the Dissociated Movement subscale of the Quality of Upper ...

263 citations

Journal ArticleDOI
TL;DR: The continuum model of tendon pathology, proposed in 2009, synthesised clinical and laboratory-based research to guide treatment choices for the clinical presentations of tendinopathy and may help guide targeted treatments and improved patient outcomes.
Abstract: The pathogenesis of tendinopathy and the primary biological change in the tendon that precipitates pathology have generated several pathoaetiological models in the literature. The continuum model of tendon pathology, proposed in 2009, synthesised clinical and laboratory-based research to guide treatment choices for the clinical presentations of tendinopathy. While the continuum has been cited extensively in the literature, its clinical utility has yet to be fully elucidated. The continuum model proposed a model for staging tendinopathy based on the changes and distribution of disorganisation within the tendon. However, classifying tendinopathy based on structure in what is primarily a pain condition has been challenged. The interplay between structure, pain and function is not yet fully understood, which has partly contributed to the complex clinical picture of tendinopathy. Here we revisit and assess the merit of the continuum model in the context of new evidence. We (1) summarise new evidence in tendinopathy research in the context of the continuum, (2) discuss tendon pain and the relevance of a model based on structure and (3) describe relevant clinical elements (pain, function and structure) to begin to build a better understanding of the condition. Our goal is that the continuum model may help guide targeted treatments and improved patient outcomes.

263 citations

Journal ArticleDOI
Graetz B1
TL;DR: Re-examines the factor structure of the 12-item GHQ for a large Australian sample of young people and shows that oblique factor rotation better approaches the criterion of simple structure, and allows separate components of the GHQ to be identified and measured using factor scores.
Abstract: This analysis re-examines the factor structure of the 12-item GHQ for a large Australian sample of young people. It shows that oblique factor rotation better approaches the criterion of simple structure, and allows separate components of the GHQ to be identified and measured using factor scores. When the performance of these separate factors is compared with composite Likert scores, it is found that they do not behave uniformly in response to outside variables, both in cross-sectional and longitudinal analyses. These results suggest that there are advantages to be gained by using the multidimensional properties of the GHQ as well as a single severity score. The additional information this yields can provide new insights into the nature of psychiatric impairment within and between samples.

262 citations


Authors

Showing all 13601 results

NameH-indexPapersCitations
Rasmus Nielsen13555684898
C. N. R. Rao133164686718
James Whelan12878689180
Jacqueline Batley119121268752
Eske Willerslev11536743039
Jonathan E. Shaw114629108114
Ary A. Hoffmann11390755354
Mike Clarke1131037164328
Richard J. Simpson11385059378
Alan F. Cowman11137938240
David C. Page11050944119
Richard Gray10980878580
David S. Wishart10852376652
Alan G. Marshall107106046904
David A. Williams10663342058
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023102
2022398
20213,407
20202,992
20192,661
20182,394