La Trobe University

About: La Trobe University is a education organization based out in Melbourne, Victoria, Australia. It is known for research contribution in the topics: Population & Health care. The organization has 13370 authors who have published 41291 publications receiving 1138269 citations. The organization is also known as: LaTrobe University & LTU.

The Enigma of Lone Wolf Terrorism: An Assessment

Abstract: Lone wolf terrorism remains an ambiguous and enigmatic phenomenon. The boundaries of lone wolf terrorism are fuzzy and arbitrary. This article aims to define and analyze the main features and patterns of lone wolf terrorism in fifteen countries. Lone wolf terrorism is shown to be more prevalent in the United States than in the other countries under study. The cross-national analysis suggests that in the United States lone wolf terrorism has increased markedly during the past three decades; a similar increase does not appear to have occurred in the other countries under study. The numbers of casualties resulting from lone wolf terrorism have been relatively limited, and there is no evidence that the lethality of lone wolf terrorism is on the increase. The rates of psychological disturbance and social ineptitude are found to be relatively high among lone wolf terrorists. Lone wolf terrorists tend to create their own ideologies that combine personal frustrations and aversion with broader political, social, or religious aims. In this process, many lone wolf terrorists draw on the communities of belief and ideologies of validation generated and transmitted by extremist movements.

Outcomes of progressive resistance strength training following stroke: a systematic review

Abstract: Objective: To determine whether progressive resistance strength training reduces impairments, activity limitations and participation restrictions after stroke.Methods: Electronic databases were searched to find trials conducted from 1966 to 2002. Articles were assessed independently by two reviewers according to the following inclusion criteria: (1) population: adults with stroke, (2) intervention: progressive resistive strength training in isolation, and (3) outcomes: changes in body function, physical activity or societal participation.Results: From the 350 articles initially identified, eight met the criteria for detailed review. Three were randomized controlled trials, with the remainder being single-case time-series analyses or pre–post trials. The five trials that measured impairments of muscle strength showed positive outcomes for progressive resistance strength training, with large effect sizes (d = 1.2–4.5). Few negative effects of strength training were reported, and these were minor. Only three...

TON_IoT Telemetry Dataset: A New Generation Dataset of IoT and IIoT for Data-Driven Intrusion Detection Systems

Abstract: Although the Internet of Things (IoT) can increase efficiency and productivity through intelligent and remote management, it also increases the risk of cyber-attacks. The potential threats to IoT applications and the need to reduce risk have recently become an interesting research topic. It is crucial that effective Intrusion Detection Systems (IDSs) tailored to IoT applications be developed. Such IDSs require an updated and representative IoT dataset for training and evaluation. However, there is a lack of benchmark IoT and IIoT datasets for assessing IDSs-enabled IoT systems. This paper addresses this issue and proposes a new data-driven IoT/IIoT dataset with the ground truth that incorporates a label feature indicating normal and attack classes, as well as a type feature indicating the sub-classes of attacks targeting IoT/IIoT applications for multi-classification problems. The proposed dataset, which is named TON_IoT, includes Telemetry data of IoT/IIoT services, as well as Operating Systems logs and Network traffic of IoT network, collected from a realistic representation of a medium-scale network at the Cyber Range and IoT Labs at the UNSW Canberra (Australia). This paper also describes the proposed dataset of the Telemetry data of IoT/IIoT services and their characteristics. TON_IoT has various advantages that are currently lacking in the state-of-the-art datasets: i) it has various normal and attack events for different IoT/IIoT services, and ii) it includes heterogeneous data sources. We evaluated the performance of several popular Machine Learning (ML) methods and a Deep Learning model in both binary and multi-class classification problems for intrusion detection purposes using the proposed Telemetry dataset.

TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1–TRAF2 complex to sensitize tumor cells to TNFα

Abstract: Synthetic inhibitor of apoptosis (IAP) antagonists induce degradation of IAP proteins such as cellular IAP1 (cIAP1), activate nuclear factor κB (NF-κB) signaling, and sensitize cells to tumor necrosis factor α (TNFα). The physiological relevance of these discoveries to cIAP1 function remains undetermined. We show that upon ligand binding, the TNF superfamily receptor FN14 recruits a cIAP1–Tnf receptor-associated factor 2 (TRAF2) complex. Unlike IAP antagonists that cause rapid proteasomal degradation of cIAP1, signaling by FN14 promotes the lysosomal degradation of cIAP1–TRAF2 in a cIAP1-dependent manner. TNF-like weak inducer of apoptosis (TWEAK)/FN14 signaling nevertheless promotes the same noncanonical NF-κB signaling elicited by IAP antagonists and, in sensitive cells, the same autocrine TNFα-induced death occurs. TWEAK-induced loss of the cIAP1–TRAF2 complex sensitizes immortalized and minimally passaged tumor cells to TNFα-induced death, whereas primary cells remain resistant. Conversely, cIAP1–TRAF2 complex overexpression limits FN14 signaling and protects tumor cells from TWEAK-induced TNFα sensitization. Lysosomal degradation of cIAP1–TRAF2 by TWEAK/FN14 therefore critically alters the balance of life/death signals emanating from TNF-R1 in immortalized cells.

An Ill Wind? Climate Change, Migration and Health

Abstract: Background: Climate change is projected to cause substantial increases in population movement in coming decades. Previous research has considered the likely causal influences and magnitude of such ...