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Institution

LAC+USC Medical Center

HealthcareLos Angeles, California, United States
About: LAC+USC Medical Center is a healthcare organization based out in Los Angeles, California, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 1348 authors who have published 886 publications receiving 21927 citations. The organization is also known as: County/USC & Los Angeles County General.


Papers
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Journal ArticleDOI
20 May 1988-Cell
TL;DR: It is concluded that c-K-ras somatic mutational activation is a critical event in the oncogenesis of most, if not all, human cancers of the exocrine pancreas.

2,146 citations

Journal ArticleDOI
TL;DR: Given its high rate of antibiotic resistance and abysmal outcomes (up to 70% mortality rate from infections caused by XDR strains in some case series), new preventative and therapeutic options for Acinetobacter spp.
Abstract: Acinetobacter is a complex genus, and historically, there has been confusion about the existence of multiple species. The species commonly cause nosocomial infections, predominantly aspiration pneumonia and catheter-associated bacteremia, but can also cause soft tissue and urinary tract infections. Community-acquired infections by Acinetobacter spp. are increasingly reported. Transmission of Acinetobacter and subsequent disease is facilitated by the organism's environmental tenacity, resistance to desiccation, and evasion of host immunity. The virulence properties demonstrated by Acinetobacter spp. primarily stem from evasion of rapid clearance by the innate immune system, effectively enabling high bacterial density that triggers lipopolysaccharide (LPS)-Toll-like receptor 4 (TLR4)-mediated sepsis. Capsular polysaccharide is a critical virulence factor that enables immune evasion, while LPS triggers septic shock. However, the primary driver of clinical outcome is antibiotic resistance. Administration of initially effective therapy is key to improving survival, reducing 30-day mortality threefold. Regrettably, due to the high frequency of this organism having an extreme drug resistance (XDR) phenotype, early initiation of effective therapy is a major clinical challenge. Given its high rate of antibiotic resistance and abysmal outcomes (up to 70% mortality rate from infections caused by XDR strains in some case series), new preventative and therapeutic options for Acinetobacter spp. are desperately needed.

618 citations

Journal ArticleDOI
TL;DR: The results of this study show that operative treatment of complex intraarticular fractures of the distal tibia remain fraught with difficulty and that the complication rates and need for further reconstructive surgery remains high.
Abstract: In a retrospective study, 58 patients with 60 tibial plafond fractures were treated by internal fixation and reviewed over an average follow-up period of 2.5 years. There were three Reudi Type I, 27 Reudi Type II, and 30 Reudi Type III fractures. Twelve fractures were open, and 60% of the fractures were the result of high-energy trauma. Results were evaluated based on a subjective and objective rating system. There were 15 good and excellent (25%), 15 fair (25%), and 30 poor results (50%). The deep infection rate in Reudi Types I and II fractures was 0%, and in Type III fractures it was 37%. The deep infection rate statistically correlated with the presence of a postoperative wound dehiscence or skin slough but not with the presence of an open fracture. Overall clinical rating correlated with the Reudi classification, quality of reduction, and the presence of a postoperative wound infection. The ankle fusion rate for Reudi Types I and II fractures was 10%, whereas that in Reudi Type III fractures was 26%. The results of this study show that operative treatment of complex intraarticular fractures of the distal tibia remain fraught with difficulty and that the complication rates and need for further reconstructive surgery remains high. If anatomic reduction without soft-tissue complications cannot be predicted preoperatively, consideration should be given to alternative types of treatment.

459 citations

Journal ArticleDOI
TL;DR: An experimental LCF system suitable for investigations of localized current field hyperthermia as an adjunct to 192Ir interstitial implantation of tumors is described and some of the physical and biological parameters pertinent to its design and safe operation are discussed.
Abstract: The efficacy of localized current field (LCF) hyperthermia as an adjunct to 192Ir interstitial implantation of tumors is currently under investigation In this article, we describe an experimental LCF system suitable for such investigations, and discuss some of the physical and biological parameters pertinent to its design and safe operation

344 citations

Journal ArticleDOI
TL;DR: Esophageal variceal sclerotherapy decreased rebleeding as evidenced by a decrease in the mean bleeding risk factor, transfusion requirement and by an increase in bleeding free interval; differences between the treated and control groups in these parameters were especially significant after variceAL obliteration.

247 citations


Authors

Showing all 1361 results

NameH-indexPapersCitations
George A. Bray131896100975
Michael C. Fishbein11670150402
Keitaro Matsuo9781837349
Frank Z. Stanczyk9362030244
Demetrios Demetriades9374231887
Thomas A. Buchanan9134948865
George C. Velmahos9164628050
Mark D. Fleming8143336107
Kenji Inaba7979724806
Willa A. Hsueh7625418588
Lester D.R. Thompson7662227526
Ajit P. Yoganathan7462621612
Uri Elkayam7327927800
Yuan-Cheng Fung6921830827
Daniel R. Mishell6836314889
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20236
202212
202146
202041
201934
201829