Ladoke Akintola University of Technology

About: Ladoke Akintola University of Technology is a education organization based out in Ogbomoso, Nigeria. It is known for research contribution in the topics: Population & Adsorption. The organization has 2786 authors who have published 3066 publications receiving 36850 citations. The organization is also known as: Oyo State University of Technology & LAUTECH.

An Unusual (10,3)‐d MOF Material with Nanoscale Helical Cavities and Multifunctionality

Abstract: The MnII and CuII compounds of 3-(2-pyridyl)-5,6-diphenyl-1,2,4-triazine-4,4′-disulfonic acid (H2pdtd) were synthesized and systematically characterized. The metal-organic framework (MOF) [Mn2(pdtd)2(H2O)4]n·5nH2O (1) was constructed by a solvothermal method preformed at 140 °C with methanol as the solvent, while [Cu(pdtd)(H2O)4]·H2O (2) was obtained by conventional solution chemistry conducted at 80 °C. Crystallographic analysis revealed that 1 has an acentric structure in which the MnII centers are linked via sulfonate groups and chelating nitrogen atoms within the pdtd ligands to give a rare noninterpenetrating (10,3)-d framework with permanent helical cavities. Consequently, 1 exhibits nonlinear optical (NLO) activity, significant CO2 sorption, and magnetic coupling. In contrast, 2 is a mononuclear complex with coordinated water and lacks functional properties.

Chemical composition and physicomechanical characteristics of sawdust ash blended cement

Abstract: The production of blended cement by incorporating sawdust ash (SDA) in Ordinary Portland Cement (OPC) clinker, during manufacturing of cement was investigated. Sawdust was collected from sawmill industry at Olope Marun, Ogbomoso, Oyo State, Nigeria. It was burnt to ash and then added as percentage replacement for OPC clinker. Chemical and physical properties of both SDA and OPC clinker were determined. The production of the SDA – blended cement was carried out by intergrinding 5–25% by weight of SDA with OPC clinker during cement manufacturing. The blended cement produced was analyzed for chemical composition and physical properties. The chemical compositions of SDA – blended cement with 5–25% SDA replacement were 19.96–22.52% for silicon oxide , 5.57–5.72% for aluminum oxide , 3.47–3.63% for iron oxide , and 65.39–57.28% for calcium oxide . The physical properties of SDA – blended cement were 5–7 mm for soundness , 391–410 m 2 /kg for fineness, 27.6–30.0% for consistency, 45–160 min for initial and 75–210 min for final setting time, 2.5–2.2 for specific gravity, and 1.33–1.45 for loss on ignition . The compressive strength of blended cement with 5–25% SDA replacement ranged from 5.2 to 9.9, 11.2–27.8, 13.9–44.0, 14.3–56.0, 15.8–58.9, 20.4–62.4, and 23.6–65.2 N/mm 2 for 1, 3, 7, 14, 28, 56, and 90 days, respectively while the flexural strength ranged from 1.8 to 2.3, 2.5–5.3, 2.8–6.3, 3.4–7.4, 3.5–8.9, 3.9–10.1, and 4.1–11.5 N/mm2, respectively. The partial replacement of OPC clinker with SDA during cement manufacturing was established. A maximum replacement level of 15% by weight of cement gave desirable engineering properties.

QT Interval prolongation and dispersion: Epidemiology and clinical correlates in subjects with newly diagnosed systemic hypertension in Nigeria

Abstract: Background: The use of easily obtainable clinical and laboratory parameters to identify hypertensive patients with increased cardiovascular risk in resource limited settings cannot be overemphasized. Prolongation of QT intervals and increased dispersion has been associated with increased risk of cardiovascular death. The study aimed at describing the epidemiology of QT interval abnormalities among newly diagnosed hypertensive subjects and associated clinical correlates. Materials and Methods: One hundred and forty newly diagnosed hypertensive subjects and 70 controls were used for this study. Clinical and sociodemographic characteristics were obtained. Twelve lead resting electrocardiography, QT dispersion, heart rate corrected minimum and maximum QT intervals were determined manually. Increased QTcmax was defined at QTcmax >440msec. QT parameters were compared between various groups. SPSS 16.0 was used for data analysis. Results: The hypertensive subjects were well matched in age and gender distribution with controls. QTmax and QTcmax were significantly higher among hypertensive subjects than controls (379.7±45.1 vs. 356.7±35.6, 447.5± 49.0 vs. 414.5 ±34.7 ms, respectively, P 440ms compared to 21.43% of controls, P=0.01. Increased QTc dispersion was present in 36.4% of hypertensive subjects. Hypertensive subjects with QT abnormalities had significantly higher mean waist hip ratio, mean body mass index and a higher proportion of smoking than controls. Conclusion: QT prolongation and increased QTc dispersion are common among newly diagnosed hypertensive Nigerians and seem to be significantly associated with obesity. Effective antihypertensive therapy and control of obesity are important management modality for newly diagnosed hypertensive patients. Key words: Clinical correlates, hypertension, Nigeria, QT dispersion, QT prolongation.

Codeine-induced hepatic injury is via oxido-inflammatory damage and caspase-3-mediated apoptosis

Abstract: Codeine (3-methylmorphine) is a known analgesic, antitussive, and antidiarrheal drug that is often abused for recreational purposes. It is metabolized in the liver via the cytochrome P450 system and thus hypothesized to induce hepatic injury especially when misused. Thus, the present study aimed at investigating changes in liver function, hepatic enzyme biomarker, proton pumps, antioxidant status, free radicals and TNF-α levels, as well as caspase 3 activities and hepatic DNA fragmentation after 6 weeks of oral codeine administration. Twenty-one male rabbits were randomized into 3 groups (n = 7). The control group had 1 ml of normal saline, while the low-dose and high-dose codeine groups received 4 and 10 mg/kg b.w of codeine respectively daily. The codeine-treated animals had significantly lower levels of serum proteins, increased activities of hepatic enzyme biomarkers and caspase 3, raised hepatic concentrations of free radicals and TNF-α, as well as increased hepatic DNA fragmentation. Codeine treatment also led to a significant decline in hepatic weight, activities of hepatic enzymatic antioxidant, Na+-K+-ATPase and Ca2+-ATPase. These alterations were more pronounced in high-dose codeine treated animals than in the low-dose group. Histopathological study showed moderate fatty degeneration of hepatic parenchyma, infiltration of the portal tract by inflammatory cells with dense collagen fibre deposition in codeine-treated animals. The present study revealed that codeine induced liver injury and hepatic DNA damage via caspase 3-dependent signaling by suppressing hepatic antioxidant status and enhancing free radical and TNF-α generation.

Laboratory Scale Preparation of Biogas from Cassava Tubers, Cassava Peels, and Palm Kernel Oil Residues

Abstract: The feasibility of utilizing cassava tuber, cassava peels, palm kernel cake, and palm kernel shells in methane production through anaerobic digestion was evaluated in this work The production of biogas from cassava tuber, cassava peels, palm kernel shell, and palm kernel cake was investigated in laboratory scale using the simple single-state digesters of 2 liter working volume The digester was fed on a batch-basis with the slurry of cassava tuber, cassava peels, palm kernel shell, and palm kernel cake containing average moisture content of 18% and operated at a temperature of 35°C for 30 days Measured biogas yields for cassava tuber, cassava peels, palm kernel cake, and palm kernel shell were 066, 066, 058, and 008 m3/(kg VS), respectively, after 30 days digestion time Methane production from cassava tuber, cassava peels, palm kernel cake, and palm kernel shell was 031, 028, 032, and 005 m3/(kg VS), respectively From this laboratory scale study, it can be concluded that cassava tuber, cassava