Ladoke Akintola University of Technology

About: Ladoke Akintola University of Technology is a education organization based out in Ogbomoso, Nigeria. It is known for research contribution in the topics: Population & Adsorption. The organization has 2786 authors who have published 3066 publications receiving 36850 citations. The organization is also known as: Oyo State University of Technology & LAUTECH.

Anti-Diarrhegenic and Anti-Ulcer Properties of Irvingia gabonensis in Rats

Abstract: The crude methanol extract of Irvingia gabonensis was evaluated for effects on gastrointestinal motility and indomethacin-induced gastric ulceration. The extract (50, 100 and 200 mg/kg, p.o.) exhibited dose-dependent inhibition of indomethacin-induced gastric ulceration that seems to be stronger than cimetidine (50 mg/kg). A significant decrease in gastric acid secretion with concomitant increase in intragastric mucous secretion was produced by the extract at all doses studied. Gastrointestinal motility was significantly reduced in the extract-treated rats. Acute toxicity studies showed there were no deaths either 24 h or 7 days after the application of the extract up to 1600 mg/kg. The results show that Irvingia gabonensis possesses anti-diarrhegenic and anti-ulcer properties. The anti-ulcer property probably act via a reduction in gastric acid secretion and an increase in the intragastric mucous secretion.

Trends in neonatal and post-neonatal tetanus admissions at a Nigerian teaching hospital.

Abstract: Introduction: Tetanus accounts for high morbidity and case fatality rates in developing countries. This study therefore aimed to identify reasons for the persistence of this disease. Methodology: Paediatric admissions at Ladoke Akintola University Teaching Hospital between 1 January 2006 and 31 December 2008 diagnosed with tetanus were studied. Data was analyzed with SPSS 18 and statistical significance was set at p < 0.05. Results: Of the total 1,681 paediatric admissions, 30 (1.8%) had tetanus. Of the 878 neonatal admissions, 8 (0.9%) had tetanus, while 22 (2.7%) of the total 803 post-neonatal admissions had tetanus. Neonatal tetanus admissions were significantly higher in 2006 compared to 2007 and 2008 (7 [2.3%] versus 1 [0.2%] [χ 2 = 7.50, P=0.01]). Of the eight mothers whose neonates had tetanus, seven did not receive tetanus toxoids in pregnancy and five (62.5%) were secondary school dropouts. Post-neonatal tetanus cases admitted in the years 2006, 2007, and 2008 were 4, 12, and 6 children respectively. Most of these 22 children did not receive tetanus toxoid immunization in their first year of life. None of the 22 children received booster doses of tetanus toxoids after their first years of life. Conclusion: Mothers at risk of their babies having tetanus, such as secondary school dropouts, must be identified antenatally and vaccinated with tetanus toxiod. Their babies should also receive good care post-delivery. Completion of routine tetanus toxoid schedule in the first year and booster doses in the post-neonatal age should be ensured.

Detection and Epidemiology of Vulvovaginal Candidiasis among Asymptomatic Pregnant Women Attending a Tertiary Hospital in Ogbomoso, Nigeria

Abstract: Vulvovaginal candidiasis (VVC) is caused by the overgrowth of Candida species, most commonly Candida albicans in the vagina and is characterized by curd-like vaginal discharge, itching and erythema. This study was conducted to determine the prevalence and to emphasize the need for proper detection of vulvovaginal candidiasis among asymptomatic pregnant women. A total of 140 pregnant women aged between 20-49 years and of gestation age of 14-36 weeks were recruited for this study. High Vaginal swabs were collected under aseptic condition. Samples collected were analyzed within one hour of collection using microscopy and culture methods. The isolates were further subjected to Germ tube test (GTT) and chromogenic agar test (CHROMagar). The rate of Candida infection was found to be 25% (n=35) among the pregnant women. The peak age of infection was 20-29 years 33.8% (n=26), no woman between the age 40 to 49 years had candidiasis. Candidiasis was significantly detected in pregnant women in the second trimester compared to those in the first (? 2 =5.952; p <0.05) and third trimesters ((? 2 =9.282; p <0.05). This study revealed a high incidence of asymptomatic vulvovaginal candidiasis among pregnant women in Ogbomoso and various Candida spp responsible for VVC were identified.