Ladoke Akintola University of Technology

About: Ladoke Akintola University of Technology is a education organization based out in Ogbomoso, Nigeria. It is known for research contribution in the topics: Population & Adsorption. The organization has 2786 authors who have published 3066 publications receiving 36850 citations. The organization is also known as: Oyo State University of Technology & LAUTECH.

Pattern and determinants of obesity among adolescent females in private and public schools in the Olorunda Local Government Area of Osun State, Nigeria: a comparative study.

Abstract: The prevalence of obesity has continued to rise at an alarming rate world-wide to such an extent that it has been described as a global epidemic. This study aims to determine the pattern and determinants of obesity among adolescent females in private and public schools in Olorunda Local Government Area of Osun state, Nigeria. This is a cross sectional descriptive study. Using the multi-stage sampling technique, 520 pre-tested semi-structured questionnaires were administered to 257 girls from the private schools and 263 girls from the public schools. Most of the respondents from private schools (65.2%) had good knowledge about obesity and related matters, while most from the public schools (65.9%) had poor knowledge. The dietary practice of majority of the girls from private schools (60.2%) was unhealthy, while most of the girls from public schools (68.7%) had healthy dietary practices. Most of the respondents from private schools (64.2%) lived sedentary lifestyles while most from the public schools (64.0%) lived active lifestyles. Using the BMI, majority of the girls from private schools were underweight (52%), 10 (4.0%) were overweight and 3 (1.2%) were obese. For the public schools, using the BMI, majority (55.4%) fell within the normal group, 6(2.3%) were overweight and none was obese. The prevalence of overweight and obesity was higher among the girls in private schools than among girls attending public schools. Awareness should be created to promote a healthy balance of food, drink and physical activity within and outside the school.

Comparative effects of sertraline, haloperidol or olanzapine treatments on ketamine-induced changes in mouse behaviours.

Abstract: Effects of sertraline, haloperidol or olanzapine administration on ketamine-induced behaviours in mice were examined. The aim was to ascertain the degree of reversal of such behaviours by sertraline, and compare its effectiveness to haloperidol and olanzapine. Ten-week old mice (N = 120) were equally divided into main groups; 1 (open-field, radial-arm maze and elevated plus maze {EPM} tests), and 2 (social interaction test). Mice in each main group were assigned into six groups of ten (n = 10) each. Group 1 received intraperitoneal (i.p) injection of vehicle, while groups 2–6 received i.p ketamine at 15 mg/kg daily for 10 days. From day 11 to 24, mice in group 1 (vehicle) were given distilled water (i.p at 2 ml/kg and oral at 10 ml/kg), group 2 (ketamine control) received daily i.p ketamine and oral distilled water; while animals in groups 3–6 received daily i.p. ketamine and oral haloperidol (4 mg/kg), olanzapine (2 mg/kg), or one of two doses of sertraline (SERT) (2.5 or 5 mg/kg), respectively. Treatments were administered daily, and behaviours assessed on days 11 and 24. Results showed that repeated ketamine administration caused hyperlocomotion, increased self-grooming, memory loss and social withdrawal. Administration of sertraline (both doses), haloperidol, and olanzapine reversed ketamine-induced behavioural changes. However, in the EPM, sertraline and olanzapine were anxiolytic, while haloperidol was anxiogenic. Sertraline’s effect on behaviours tested was comparable to olanzapine and better than haloperidol. In conclusion, this study shows that sertraline’s ability to counteract ketamine-induced behavioural changes in mice is comparable to known antipsychotics.

Intestinal helminthiases among rural and urban schoolchildren in south-western Nigeria.

Abstract: The prevalences and intensities of intestinal helminthic infection among primary schoolchildren were determined in rural and urban communities of the Ife Central local government area, in south-western Nigeria. After the schools in the study area had been stratified into urban and rural, a random sample from each stratum was selected for further study. In each study school, a single fresh stool specimen was obtained from each pupil in randomly selected classes and checked, using a quantitative method (Stoll's dilution egg-count technique), for helminth eggs and larvae. Overall, 366 rural and 383 urban schoolchildren were investigated and 30.0% of them (36.1% of the rural and 24.3% of the urban; P<0.001) were found to be harbouring at least one species of intestinal helminth. The mean intensities of infection, in terms of excreted eggs/g faeces of those infected, were 2371.4 for Ascaris, 1070.6 for hookworm, and 500 for Trichuris. Although the mean intensities of Ascaris infection were significantly lower among the infected rural children than among the infected urban (2025.7 v. 2791.4; P=0.014), the corresponding difference in the hookworm infections did not reach statistical significance (1458 v. 666.7; P=0.063). The means of the log-transformed egg outputs, in eggs/g faeces of those infected, also showed similar trends: a significant difference between the rural and urban Ascaris infections (3.1877 v. 3.3340; P=0.002) but not between the rural and urban hookworm infections (2.9667 v. 2.8027; P=0.453). Intestinal helminthiases still clearly represent a common childhood health problem in the study area, particularly in the rural communities.

Anticlastogenic effects of Hibiscus sabdariffa fruits against sodium arsenite-induced micronuclei formation in erythrocytes in mouse bone marrow.

Abstract: An in vivo micronucleus assay using albino mice was used to examine the anticlastogenic effects of a crude aqueous extract of Hibiscus sabdariffa fruits in bone marrow cells of mice. Various doses of freshly prepared crude extract of Hibiscus sabdariffa (50, 100 and 150 mg/kg b.w.) were given by gavaging to male laboratory bred Swiss albino mice for 7 days as a dietary supplement followed by a single dose of sodium arsenite (2.5 mg/kg b.w.) After 24 h, the animals were killed and bone marrow smears were prepared and stained in Giemsa. The results show that sodium arsenite effectively induced micronuclei in polychromatic erythrocytes (PCEs). Administration of a crude extract of Hibiscus sabdariffa led to a significant reduction of micronuclei in PCEs. The results also show that a combination of Hibiscus sabdariffa and sodium arsenite reduced significantly the frequencies of micronucleated PCEs induced by sodium arsenite.