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Institution

Ladoke Akintola University of Technology

EducationOgbomoso, Nigeria
About: Ladoke Akintola University of Technology is a education organization based out in Ogbomoso, Nigeria. It is known for research contribution in the topics: Population & Adsorption. The organization has 2786 authors who have published 3066 publications receiving 36850 citations. The organization is also known as: Oyo State University of Technology & LAUTECH.


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Journal ArticleDOI
TL;DR: The results obtained support the fact that some caution should be paid regarding the dosage and the frequency of use of Z. zanthoxyloides extract, and suggest that it can be consumed safely at relatively high concentrations.
Abstract: Objectives: This study aimed at investigating the genotoxicity and cytotoxicity effect of Tapinathus globiferus and Zanthoxylum zanthoxyloides to human leukocytes. In addition, the reductive potential and the chemical composition of the two plant extracts were also determined. Methods: Human leukocytes were obtained from healthy volunteer donors. The genotoxicity and cytotoxicity of T. globiferus and Z. zanthoxyloides were assessed using the Comet assay and Trypan blue exclusion respectively. The antioxidant activity of the plant extracts was evaluated by the reducing power assay. Furthermore, HPLC-DAD was used to characterize and quantify the constituents of these plants. Results: T. globiferus (10-150 µg/mL) was neither genotoxic nor cytotoxic at the concentrations tested, suggesting that it can be consumed safely at relatively high concentrations. However, Z. zanthoxyloides showed cytoxicity and genotoxicity to human leukocytes at the highest concentration tested (150 µg/mL). In addition, the total reducing power of T. globiferus was found higher than Z. zanthoxyloides in potassium ferricyanide reduction. Both plants extract contained flavonoids (rutin and quercetin) and phenolic acids (chlorogenic and caffeic). Conclusion: The results obtained support the fact that some caution should be paid regarding the dosage and the frequency of use of Z. zanthoxyloides extract.

18 citations

Journal ArticleDOI
01 Jan 2018
TL;DR: In this article, the authors investigated the thermochemical properties of separate components of jatropha biomass residues of Nigerian origin towards bio-oil production and found that the properties of these components were comparable with those in the literature.
Abstract: This study investigates the thermochemical properties of the separate components of jatropha biomass residues of Nigerian origin towards bio-oil production. The biomass residues (Jatropha curcas fruit shells and seed coat) were obtained from their mature jatropha fruits and subjected to physico-chemical characterization (structural composition analysis, thermogravimetric analysis, proximate and ultimate analyses). The structural compositions (extractives, hemicellulose, cellulose and lignin contents) of jatropha fruit shell and jatropha seed coat were 3%, 34.0%, 40.0% and 12.7%, and 42.3%, 32.5%, 10.5% and 5.7%, respectively. The thermogravimetric analysis showed that the ash contents of jatropha seed coat and jatropha fruit shell were 0.8% and 15.4%, respectively. The carbon contents were 48.3% and 41.5%, while measured calorific values were 20.06 MJ/kg and 17.14 MJ/kg for jatropha seed coat and fruit shell, respectively. The carbon, hydrogen, nitrogen and sulphur contents were found comparable with those in the literature. This study indicated that the thermochemical properties of the Nigerian Jatropha fruit and seeds residues were comparable with literature values and residues were found suitable for bio-oil production.

18 citations

Journal ArticleDOI
TL;DR: The stroke prevalence in Nigeria is lower than previously recorded rates and further studies will be required to investigate other factors which may play a role.
Abstract: Background: Stroke is a life-changing, debilitating complication of sickle cell disease (SCD). Previous studies had recorded high stroke prevalence amongst this group of patients. Nigeria has a large population of people affected by this condition and this study aims to assess the stroke prevalence in this large population. Methodology: Stroke prevalence data from 14 physicians working in 11 tertiary health centres across the country was collated by doctors using the sickle cell registers and patient case notes. This data was then collated and used to obtain the overall stroke prevalence in adult and children. Results: The stroke prevalence in sickle cell disease patients in Nigeria was observed to be 12.4 per 1000 patients. Prevalence in the adult patients was 17.7 per 1000 patients and 7.4 per 1000 patients in children. Twenty three percent of the affected patients had more than stroke episode. Conclusion: The stroke prevalence in Nigeria is lower than previously recorded rates and further studies will be required to investigate other factors which may play a role.

18 citations

Journal ArticleDOI
TL;DR: In this paper, two isolated micro-organisms (Bacillus subtilis and Pseudomonas fragii) were used to reduce the concentrations of chemical oxygen demand (COD), total suspended solids (TSS), and chloride.
Abstract: Tannery wastewater treatment using two isolated micro-organisms (Bacillus subtilis and Pseudomonas fragii) has been investigated in the present study. The growth patterns, pH normalisation and the abilities of these micro-organisms to reduce the concentrations of chemical oxygen demand (COD), total suspended solids (TSS) and chloride were studied using the shake flask apparatus. The specific growth rate and biomass concentration of B. subtilis and P. fragii were observed 0.138 h−1 and 3.01 mg/l and 0.051 h−1 and 2.34 mg/l, respectively, after 84 h. Both micro-organisms normalised pH of the wastewater. COD removal efficiency for B. subtilis was 87.6% while that of P. fragii was 85.2%. For TSS, B. subtilis caused a reduction of 91.7% (from 876 mg/l to 73 mg/l), while P. fragii reduced the solid concentration from 876 mg/l to 98 mg/l (88.8%). B. subtilis could only achieve 48.5% reduction in chloride concentration (from 127.08 mg/l to 65.39 mg/l compared to a reduction of 54.6% (from 127.08 mg/l to ...

18 citations

Journal ArticleDOI
TL;DR: In this article, the authors evaluated the nutritive contents, free radical scavenging activities and phytochemical components of C. lanatus (Watermelon) fruit extract using 1,1-di-phenylpicryl-hydrazyl radical (DPPH) and hydrogen peroxide radicals scavenging assays.
Abstract: Citrullus lanatus (Watermelon) is a fruit cultivated and consumed in Africa for its essential nutrients which are very beneficial to the human body. The present study was designed to evaluate the nutritive contents, free radical scavenging activities and phytochemical components of C. lanatus fruit. The extract of the fruit was subjected to in vitro antioxidant assessment using 1,1-di-phenylpicryl-hydrazyl radical (DPPH) and hydrogen peroxide radical scavenging assays. The proximate and phytochemical analyses were conducted using standard procedures. The results of this study showed that C. lanatus fruit had very high moisture content and its crude protein, crude fat, crude fibre and ash content were all in traceable amounts. The sugar content was considerably high in comparison with other nutritive contents. Lycopene and β-carotene contents of C. lanatus fruit were estimated to be 4537.83 and 308.71 μg/100g respectively. The gross energy evaluation showed a value of 0.335 Kcal/g. The fruit extract exhibited significant (p < 0.05) DPPH (IC50 of 0.10 mg/ml) and hydrogen peroxide radicals scavenging activity (IC50 of 0.62 mg/ml) in comparison with the positive control butylated hydroxytoluene (BTH). This study therefore recommends that C. lanatus fruit could be an excellent source of antioxidants which may prevent diseases whose pathogenesis involves oxidative stress.

18 citations


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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202310
202221
2021365
2020366
2019256
2018227