Ladoke Akintola University of Technology

About: Ladoke Akintola University of Technology is a education organization based out in Ogbomoso, Nigeria. It is known for research contribution in the topics: Population & Adsorption. The organization has 2786 authors who have published 3066 publications receiving 36850 citations. The organization is also known as: Oyo State University of Technology & LAUTECH.

An Approach to the Simulation of Natural-Convective Heat Transfer between Two Concentric Horizontal Cylindrical Annuli

Abstract: The effects of Rayleigh and Prandtl number, diameter, and temperature difference ratio in the ranges 102 ≤ Ra ≤ 105, 10−3 ≤ Pr ≤ 103, 0.8 ≤ L ≤ 2.0, and 0 ≤ J ≤ 2.0, respectively on the heat function in a concentric horizontal cylindrical annulus are investigated numerically. The results show that heat transfer in a cylindrical annulus is enhanced by making the gap width smaller than the cylinder inner radius. Both the Rayleigh and Prandtl numbers and the temperature difference ratio have very strong effects on the heat function profiles.

Impacts of flood disaster in Agege local government area Lagos, Nigeria

Abstract: Against the background of incessant occurrence of flood and its devastating impacts on residents, the paper focused on the causes and effects of flood in Agege local government area of Lagos state. Data were collected through the use of structured questionnaire from the respondents. A total of two hundred and seven (207) questionnaires were administered to the respondents in the study area. The questionnaires were distributed using the systematic random technique at interval of ten housing units. Data collected were analyzed through the use of descriptive statistical analysis such as cross-tabulation and frequency. The study reveals that the major cause of flood in the study area was the non-functionality of the drainage system (65.89%) or total absence of the drainage system (37.68%) as the case may be. Also, high rainfall (65.22%) and dumping of waste into the drainage and water bodies (44.93%) have contributed to the regular occurrence of flood in the area. The regular re-occurrence of flood in the area has also been detrimental to the health of the residents of ALG Area. The study recommends enforcement of environmental laws that will restrict dumping of waste into the water body and sponsoring of public awareness and educative programs on how man’s activities has contributed to flood occurrence. Also, the repair and construction of drainage system should also be sponsored by the government at various level as well as proper channelization of river bodies to prevent overflow during heavy downpour. This will undoubtedly control its occurrence.

Progestogen-only injectable contraceptive: Experience of women in Osogbo southwestern Nigeria.

Abstract: Background: Progestogen-only injectable contraceptive is a long-acting contraceptive given intramuscularly to give protection against unwanted pregnancy for a period of 2 or 3 months, depending on the type. Alterations in menstrual pattern are a well known side effect of this effective contraceptive method. Objectives: To determine the characteristics of women accepting the method, complications and indications for discontinuation. Materials and Methods: This was a retrospective review of clients using progestogen-only injectable contraceptive between 1 st January, 2001 and 31 st December, 2009. Relevant information extracted from the case notes was analyzed. Survival analysis was carried out using Log-Rank Chi-square test to measure association over 12-month period of usage. Level of significance was set at P value less than 0.05. Results: A total of 1,967 women used contraception during the study period and 433 (22.1%) made progestogen-only injectable their method of choice. 199(45.96%) used NET-EN, while DMPA was used by234 (54.04%) women. Many of the women (197, 45.5%) used the method for terminal fertility control. Menstrual abnormality was the commonest (264, 71.4%) complaint about progestogen-only injectable contraceptive, of which amenorrhea was experienced by constituted 176(66.7%). Eighty-three (22.4%) women had discontinued the contraceptive, and menstrual abnormality was the commonest reason for the discontinuation (68, 81.9%). No pregnancy was reported among the women that came for follow up while on the method. Conclusion: Short duration of POIC use that is within 12 months is still high. However the main reason for discontinuation was found to be due to menstrual irregularities, hence the need for effective education of the women about this side effect, thus increasing the acceptance and continuation rate of the contraceptive method.

Target-based drug discovery, ADMET profiling and bioactivity studies of antibiotics as potential inhibitors of SARS-CoV-2 main protease (Mpro)

Abstract: A recent outbreak of a new strain of Coronavirus (SARS-CoV-2) has become a global health burden, which has resulted in deaths. No proven drug has been found to effectively cure this fast-spreading infection, hence the need to explore old drugs with the known profile in tackling this pandemic. A computer-aided drug design approach involving virtual screening was used to obtain the binding scores and inhibiting efficiencies of previously known antibiotics against SARS-CoV-2 main protease (Mpro). The drug-likeness analysis of the repurposed drugs were done using the Molinspiration chemoinformatics tool, while the Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) analysis was carried out using ADMET SAR-2 webserver. Other analyses performed include bioactivities of the repurposed drug as a probable anti-SARS-CoV-2 agent and oral bioavailability analyses among others. The results were compared with those of drugs currently involved in clinical trials in the ongoing pandemic. Although antibiotics have been speculated to be of no use in the treatment of viral infections, literature has emerged lately to reveal the antiviral potential and immune-boosting ability of antibiotics. This study identified Tarivid and Ciprofloxacin with binding affinities of - 8.3 kcal/mol and - 8.1 kcal/mol, respectively as significant inhibitors of SARS-CoV-2 (Mpro) with better pharmacokinetics, drug-likeness and oral bioavailability, bioactivity properties, ADMET properties and inhibitory strength compared to Remdesivir (- 7.6 kcal/mol) and Azithromycin (- 6.3 kcal/mol). These observations will provide insight for further research (clinical trial) in the cure and management of COVID-19.