Ladoke Akintola University of Technology

About: Ladoke Akintola University of Technology is a education organization based out in Ogbomoso, Nigeria. It is known for research contribution in the topics: Population & Adsorption. The organization has 2786 authors who have published 3066 publications receiving 36850 citations. The organization is also known as: Oyo State University of Technology & LAUTECH.

Factors influencing the economic efficiency of goat production in ogbomoso agricultural zone, oyo state, nigeria

Abstract: This study investigated factors influencing the economic efficiency of goat production in Ogbomoso agricultural zone of Oyo State. The study made use of cross-sectional data sampled from eighty goat farmers with the aid of structured questionnaire. It was observed from the findings that the factors affecting the economic efficiency of goat production were years of establishment, education, feeding and number of herds. The mean economic efficiency was 0.595.

Efficacy of artemisinin combination therapy for the treatment of uncomplicated falciparum malaria in Nigerian children

Abstract: Introduction: The development and spread of Plasmodium falciparum resistance to most commonly used antimalarials remain a major challenge in the control of malaria. Constant monitoring of drug efficacy is an important tool in establishing rational antimalarial drug policies. Methodology: A randomized comparative study was conducted at the Wesley Guild Hospital, Ilesa, Nigeria between February 2010 and September 2011 comparing the efficacy and safety of artemether-lumefantrine (Coartem) and fixed dose of artesunate plus amodiaquine (Larimal) in the treatment of uncomplicated P. falciparum malaria in children betweem 6 and 144 months of age. P. falciparum malaria parasitemia was assessed by microscopy and rapid diagnostic test. Drugs were administered according to age for three days under supervision. The primary efficacy endpoint was a day 28 PCR-corrected parasitological cure. Results: A total of 182 patients were enrolled in the two treatment groups, Coartem (n = 101) and Larimal (n = 81), and tested after 28 days. In the intention-to-treat population, Coartem (n= 101) and Larimal (n= 81) had a PCR-corrected cure rate of 98% and 100% respectively, while in the per-protocol population, Coartem (n = 89) and Larimal (n = 71) both had a PCR-corrected cure rate of 100% at day 28. Although parasite and fever clearance time was faster in the Larimal group, no significant difference was observed between the two drugs. No serious adverse effects were reported. Conclusion: Five years after being introduced in Nigeria, both Coartem and Larimal have been shown to be safe and highly effective in the treatment of uncomplicated P. falciparum malaria in children.

Effect of Aqueous Leaf Extract of Acalypha wilkesiana on Hematological Parameters in Male Wistar Albino Rats

Abstract: Aims: The aim of this study is to evaluate the effect of aqueous leaf extract of Acalypha wilkesiana on hematological parameters in male wistar rats. Study Design: In_vivo. Place and Duration of Study: Department of Biochemistry, Faculty of Natural Sciences, Ambrose Alli University, Ekpoma Nigeria, between August 2011 and October 2011. Methodology: Thirty two male wistar rats of average body weights 167.50g were grouped into four (I-IV), of eight rats each. Group I received distilled water (control), while constituted doses of 2500, 5000 and 10000 mg/kg body weight of the extract were administered once daily for 14 days to animals in group II, III and IV respectively. The effect of administration of this extract on hematological parameters was evaluated. Results: Results showed that the extract did not exhibit any significant effect (P>0.05) on packed cell volume, hemoglobin, red blood cell count, white blood cell, neutrophil, lymphocytes, platelets, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, and erythrocyte sedimentation rate at all the administered doses of the extract. There was a significant reduction in mean corpuscular volume at all doses of the administered extract when compared with the control. Conclusion: The extract may be considered relatively hematotoxic at a dose of 2500 mg/kg due to its potentials to cause the formation of microcytic RBC’s.

Target organ damage and associated clinical conditions in newly diagnosed hypertensives attending a tertiary health facility.

Abstract: Background: Despite the ease of detecting and making a diagnosis of hypertension, various population surveys have shown low awareness and treatment rates of hypertension. Failure to detect and make a diagnosis of hypertension leads to late presentation and institution of treatment with consequent development of target organ damage (TOD) and associated clinical conditions (ACC) which in turn are associated with increased cost of treatment, morbidity and mortality. Objective: This study was aimed at determining the presence and severity of TOD and ACC in newly diagnosed hypertensives with a view to ascertaining the magnitude of the problem. Method: The study was carried out at Ladoke Akintola University of Technology Teaching Hospital Osogbo, Nigeria. Target organ damage (TOD) and associated clinical conditions (ACC) were determined in successive newly diagnosed hypertensives that presented at the centre during the study period. Result: Of 147 newly diagnosed hypertensives seen at Ladoke Akintola University of Technology Teaching Hospital Osogbo, Nigeria, TOD and ACC were found in 98 (66.7 %). The most prevalent TOD and ACC were LVH (42.2 %), diabetes mellitus (14.3 %), CVD (10.9 %) and heart failure (8.8 %). Patients with TOD and ACC were significantly older (p = 0.028), had significantly higher SBP (p = 0.003), higher DBP (p = 0.022) and significantly lower BMI (p = 0.046) when compared with patients without TOD and ACC. Conclusion: This study showed presence of TOD and ACC in two-thirds of newly diagnosed hypertensives. This underscores the need for improvement in the awareness, detection and treatment of hypertension in order to prevent TOD and ACC. Keywords : Target organ damage, Associated clinical conditions, Newly diagnosed hypertensives Nigerian Journal of Clinical Practice Vol. 10 (4) 2007 pp. 319-325

Isothermal studies of adsorption of acenaphthene from aqueous solution onto activated carbon produced from rice (Oryza sativa) husk

Abstract: Rice husk (RH), which is an agricultural waste material of environmental impact, was carbonized at 300–600°C in an oven for 2 h, after which its adsorption capacities were investigated for the adsorption of acenaphthene in synthetic aqueous solution with various concentrations (50–150 mg/L). The yields of carbon obtained from the raw RH ranged from 20 to 40% (w/w), while the adsorption capacities of RH increased with increasing carbonization temperature (300–600°C) and increasing initial concentration of acenaphthene (50–150 mg/L). The removal efficiencies (REs) of the RH increased from 71.37 to 80.56% as the carbonization temperature increased from 300 to 600°C, but decreased with increasing initial concentration of acenaphthene. The adsorption equilibrium data obtained fitted well to Freundlich, Langmuir, Temkin and Dubinin–Radushkevich isotherms with minimum correlation values of 0.998, 0.926, 0.966 and 0.922, respectively, although they generally decreased with increasing carbonization temper...