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Lakehead University

EducationThunder Bay, Ontario, Canada
About: Lakehead University is a education organization based out in Thunder Bay, Ontario, Canada. It is known for research contribution in the topics: Population & Control theory. The organization has 3673 authors who have published 8715 publications receiving 216423 citations.

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Journal ArticleDOI
TL;DR: Brief and efficient programs for using SPSS and SAS to conduct parallel analyses and the MAP test are described.
Abstract: Popular statistical software packages do not have the proper procedures for determining the number of components in factor and principal components analyses. Parallel analysis and Velicer's minimum average partial (MAP) test are validated procedures, recommended widely by statisticians. However, many researchers continue to use alternative, simpler, but flawed procedures, such as the eigenvalues-greater-than-one rule. Use of the proper procedures might be increased if these procedures could be conducted within familiar software environments. This paper describes brief and efficient programs for using SPSS and SAS to conduct parallel analyses and the MAP test.

3,511 citations

Journal ArticleDOI
24 Oct 2008-Science
TL;DR: It is shown that H2S is physiologically generated by cystathionine γ-lyase (CSE) and that genetic deletion of this enzyme in mice markedly reduces H 2S levels in the serum, heart, aorta, and other tissues.
Abstract: Studies of nitric oxide over the past two decades have highlighted the fundamental importance of gaseous signaling molecules in biology and medicine The physiological role of other gases such as carbon monoxide and hydrogen sulfide (H2S) is now receiving increasing attention Here we show that H2S is physiologically generated by cystathionine γ-lyase (CSE) and that genetic deletion of this enzyme in mice markedly reduces H2S levels in the serum, heart, aorta, and other tissues Mutant mice lacking CSE display pronounced hypertension and diminished endothelium-dependent vasorelaxation CSE is physiologically activated by calcium-calmodulin, which is a mechanism for H2S formation in response to vascular activation These findings provide direct evidence that H2S is a physiologic vasodilator and regulator of blood pressure

2,090 citations

Journal ArticleDOI
Sandra Díaz1, Sebsebe Demissew2, Julia Carabias3, Carlos Alfredo Joly4, Mark Lonsdale, Neville Ash5, Anne Larigauderie, Jay Ram Adhikari, Salvatore Arico6, András Báldi, Ann M. Bartuska7, Ivar Andreas Baste, Adem Bilgin, Eduardo S. Brondizio8, Kai M. A. Chan9, Viviana E. Figueroa, Anantha Kumar Duraiappah, Markus Fischer, Rosemary Hill10, Thomas Koetz, Paul Leadley11, Philip O'b. Lyver12, Georgina M. Mace13, Berta Martín-López14, Michiko Okumura5, Diego Pacheco, Unai Pascual15, Edgar Selvin Pérez, Belinda Reyers16, Eva Roth17, Osamu Saito18, Robert J. Scholes19, Nalini Sharma5, Heather Tallis20, Randolph R. Thaman21, Robert T. Watson22, Tetsukazu Yahara23, Zakri Abdul Hamid, Callistus Akosim, Yousef S. Al-Hafedh24, Rashad Allahverdiyev, Edward Amankwah, T. Stanley Asah25, Zemede Asfaw2, Gabor Bartus26, Anathea L. Brooks6, Jorge Caillaux27, Gemedo Dalle, Dedy Darnaedi, Amanda Driver (Sanbi), Gunay Erpul28, Pablo Escobar-Eyzaguirre, Pierre Failler29, Ali Moustafa Mokhtar Fouda, Bojie Fu30, Haripriya Gundimeda31, Shizuka Hashimoto32, Floyd Homer, Sandra Lavorel33, Gabriela Lichtenstein34, William Armand Mala35, Wadzanayi Mandivenyi, Piotr Matczak36, Carmel Mbizvo, Mehrasa Mehrdadi, Jean Paul Metzger37, Jean Bruno Mikissa38, Henrik Moller39, Harold A. Mooney40, Peter J. Mumby41, Harini Nagendra42, Carsten Nesshöver43, Alfred Oteng-Yeboah44, György Pataki45, Marie Roué, Jennifer Rubis6, Maria Schultz46, Peggy Smith47, Rashid Sumaila9, Kazuhiko Takeuchi18, Spencer Thomas, Madhu Verma48, Youn Yeo-Chang49, Diana Zlatanova50 
National University of Cordoba1, Addis Ababa University2, National Autonomous University of Mexico3, State University of Campinas4, United Nations Environment Programme5, UNESCO6, United States Department of Agriculture7, Indiana University8, University of British Columbia9, Commonwealth Scientific and Industrial Research Organisation10, University of Paris-Sud11, Landcare Research12, University College London13, Autonomous University of Madrid14, University of Cambridge15, Council for Scientific and Industrial Research16, University of Southern Denmark17, United Nations University18, Virginia Tech College of Natural Resources and Environment19, The Nature Conservancy20, University of the South Pacific21, University of East Anglia22, Kyushu University23, King Abdulaziz City for Science and Technology24, University of Washington25, Budapest University of Technology and Economics26, Environmental Law Institute27, Ankara University28, University of Portsmouth29, Chinese Academy of Sciences30, Indian Institute of Technology Bombay31, Kyoto University32, Joseph Fourier University33, National Scientific and Technical Research Council34, University of Yaoundé35, Polish Academy of Sciences36, University of São Paulo37, École Normale Supérieure38, University of Otago39, Stanford University40, University of Queensland41, Azim Premji University42, Helmholtz Centre for Environmental Research - UFZ43, University of Ghana44, Corvinus University of Budapest45, Stockholm University46, Lakehead University47, Indian Institute of Forest Management48, Seoul National University49, Sofia University50
TL;DR: The first public product of the Intergovernmental Platform on Biodiversity and Ecosystem Services (IPBES) is its Conceptual Framework as discussed by the authors, which will underpin all IPBES functions and provide structure and comparability to the syntheses that will produce at different spatial scales, on different themes, and in different regions.

1,585 citations

Journal ArticleDOI
Rui Wang1
TL;DR: The important life-supporting role of hydrogen sulfide (H(2)S) has evolved from bacteria to plants, invertebrates, vertebrate, vertebrates, and finally to mammals, but over the centuries it had only been known for its toxicity and environmental hazard.
Abstract: The important life-supporting role of hydrogen sulfide (H2S) has evolved from bacteria to plants, invertebrates, vertebrates, and finally to mammals. Over the centuries, however, H2S had only been known for its toxicity and environmental hazard. Physiological importance of H2S has been appreciated for about a decade. It started by the discovery of endogenous H2S production in mammalian cells and gained momentum by typifying this gasotransmitter with a variety of physiological functions. The H2S-catalyzing enzymes are differentially expressed in cardiovascular, neuronal, immune, renal, respiratory, gastrointestinal, reproductive, liver, and endocrine systems and affect the functions of these systems through the production of H2S. The physiological functions of H2S are mediated by different molecular targets, such as different ion channels and signaling proteins. Alternations of H2S metabolism lead to an array of pathological disturbances in the form of hypertension, atherosclerosis, heart failure, diabetes...

1,560 citations


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Nancy Eisenberg11849359267
David Richards9557847107
Sunil R. Lakhani9037738652
Yves Bergeron8965627494
John R. Graham8132641549
Yiyu Yao7844324468
Changhui Peng7244919000
Rui Wang7222825599
Bunsho Ohtani7137119052
Wei Jin7192921569
J. David Cassidy6316414534
Frank C. Hawthorne6262317927
John R. Lawrence6017811793
Barbara A. Parker6016012233
Peter C. Burns5959117705
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