Showing papers by "Lancaster University published in 2007"

Entrepreneurship education: a systematic review of the evidence

Abstract: The purpose of this article is to explore different themes within entrepreneurship education via the use of a systematic literature review (SLR) Systematic literature reviews are recognized method

Genome-wide association study of prostate cancer identifies a second risk locus at 8q24

Abstract: Recently, common variants on human chromosome 8q24 were found to be associated with prostate cancer risk. While conducting a genome-wide association study in the Cancer Genetic Markers of Susceptibility project with 550,000 SNPs in a nested case-control study (1,172 cases and 1,157 controls of European origin), we identified a new association at 8q24 with an independent effect on prostate cancer susceptibility. The most significant signal is 70 kb centromeric to the previously reported SNP, rs1447295, but shows little evidence of linkage disequilibrium with it. A combined analysis with four additional studies (total: 4,296 cases and 4,299 controls) confirms association with prostate cancer for rs6983267 in the centromeric locus (P = 9.42 x 10(-13); heterozygote odds ratio (OR): 1.26, 95% confidence interval (c.i.): 1.13-1.41; homozygote OR: 1.58, 95% c.i.: 1.40-1.78). Each SNP remained significant in a joint analysis after adjusting for the other (rs1447295 P = 1.41 x 10(-11); rs6983267 P = 6.62 x 10(-10)). These observations, combined with compelling evidence for a recombination hotspot between the two markers, indicate the presence of at least two independent loci within 8q24 that contribute to prostate cancer in men of European ancestry. We estimate that the population attributable risk of the new locus, marked by rs6983267, is higher than the locus marked by rs1447295 (21% versus 9%).

The focusing of electron flow and a Veselago lens in graphene p-n junctions.

Abstract: The focusing of electric current by a single p-n junction in graphene is theoretically predicted. Precise focusing may be achieved by fine-tuning the densities of carriers on the n- and p-sides of the junction to equal values. This finding may be useful for the engineering of electronic lenses and focused beam splitters using gate-controlled n-p-n junctions in graphene-based transistors.

Caution! Transitions Ahead: Politics, Practice, and Sustainable Transition Management:

Abstract: Green is not alone in contending that `̀ environmental c̀rises' require fundamental changes in the socio-technological structure of the way we live and work.''(1) For those concerned with sustainability, the idea of transitionöof substantial change and movement from one state to anotheröhas powerful normative attractions. If `we' can steer change, shape future development, and manage movement in desired directions, perhaps `we' can make the environment a better and more sustainable place in which to live. But how so to do? In a manifestly complex world dominated by hegemonic ideologies of neoliberal capitalism, global finance, and commodity flows is it really possible to intervene and deliberately shift technologies, practices, and social arrangementsönot to mention their systemic interaction and interdependenciesöonto an altogether different, altogether more sustainable track? Across the board there is growing recognition of the holistic, unavoidably interrelated nature of contemporary environmental problems and of the need for fresh approaches and forms of governance capable of engaging with complex challenges of this kind. Theories and models of sustainable transition management, derived from a blend of academic traditions in innovation, history, and technology, appear to fit this bill and it is no wonder that they are now catching on across a number of policy domains. In the Netherlands, government-sponsored programmes have explicitly adopted methods of `transition management' (Kemp and Loorbach, 2006) and in the UK, the policy relevance of similar theories and methods is being explored and actively promoted through projects and events like those supported by the ESRC's Sustainable Technologies Programme. Academically, and in just a few years, there has been rapid growth in the transition management literature and in the appeal of approaches characterised by an alluring combination of agency, complexity, uncertainty, and optimism. We do not intend to provide a thorough review or critique of what is in any case a burgeoning and quickly evolving literature, but at a time when the notion of transition management is capturing so much attention it is as well to reflect on the distinctive features of this particular policy innovation. With this limited aim in mind, we offer some cautionary comments and identify a handful of questions that deserve more explicit attention. The notion of transition is firmly rooted in traditions of system thinking which highlight the coevolution of the social and the technical and which seek to understand and analyse the emergence, transformation, and decay of sociotechnical systems. Much of the `systems in transition' literature makes use of Rip and Kemp's (1998) `multilevel' model of innovation which distinguishes between the macrolevel of the sociotechnical landscape, the mesolevel regime, and the microlevel niche. The key Commentary Environment and Planning A 2007, volume 39, pages 763 ^ 770

Glutamate in plants: metabolism, regulation, and signalling

Abstract: Glutamate occupies a central position in amino acid metabolism in plants. The acidic amino acid is formed by the action of glutamate synthase, utilizing glutamine and 2-oxoglutarate. However, glutamate is also the substrate for the synthesis of glutamine from ammonia, catalysed by glutamine synthetase. The alpha-amino group of glutamate may be transferred to other amino acids by the action of a wide range of multispecific aminotransferases. In addition, both the carbon skeleton and alpha-amino group of glutamate form the basis for the synthesis of gamma-aminobutyric acid, arginine, and proline. Finally, glutamate may be deaminated by glutamate dehydrogenase to form ammonia and 2-oxoglutarate. The possibility that the cellular concentrations of glutamate within the plant are homeostatically regulated by the combined action of these pathways is examined. Evidence that the well-known signalling properties of glutamate in animals may also extend to the plant kingdom is reviewed. The existence in plants of glutamate-activated ion channels and their possible relationship to the GLR gene family that is homologous to ionotropic glutamate receptors (iGluRs) in animals are discussed. Glutamate signalling is examined from an evolutionary perspective, and the roles it might play in plants, both in endogenous signalling pathways and in determining the capacity of the root to respond to sources of organic N in the soil, are considered.

Human-Machine Reconfigurations: Plans and situated actions (2nd edition).

Abstract: This book considers how agencies are currently figured at the human– machine interface and how they might be imaginatively and materially reconfigured. Contrary to the apparent enlivening of objects promised by the sciences of the artificial, the author proposes that the rhetorics and practices of those sciences work to obscure the performative nature of both persons and things. The question then shifts from debates over the status of humanlike machines to that of how humans and machines are enacted as similar or different in practice and with what theoretical, practical, and political consequences. Drawing on recent scholarship across the social sciences, humanities, and computing, the author argues for research aimed at tracing the differences within specific sociomaterial arrangements without resorting to essentialist divides. This requires expanding our unit of analysis, while recognizing the inevitable cuts or boundaries through which technological systems are constituted.

Flexibility from a supply chain perspective: definition and review

Abstract: Purpose – A growing body of literature has begun to recognise that in the era of supply chain management it is important to look beyond the flexible factory to the flexible supply chain. This paper seeks to further our understanding of supply chain flexibility and provide a comprehensive review of the available literature.Design/methodology/approach – Published literature on supply chain flexibility has been considered. Where appropriate, additional insights have been obtained from related streams such as manufacturing flexibility, agility and supply chain responsiveness.Findings – Much of the existing research has a limited definition of supply chain flexibility and describes flexibility simply as a reactive means to cope with uncertainty. Supply chain flexibility has emerged from the manufacturing flexibility literature and hence to date is largely confined to a manufacturing context (neglecting the role of services). Empirical research often takes the form of a cross‐sectional postal questionnaire cond...

Asparagine in plants

Abstract: Interest in plant asparagine has rapidly taken off over the past 5 years following the report that acrylamide, a neurotoxin and potential carcinogen, is present in cooked foods, particularly carbohydrate-rich foods such as wheat and potatoes which are subjected to roasting, baking or frying at high temperatures. Subsequent studies showed that acrylamide could be formed in foods by the thermal degradation of free asparagine in the presence of sugars in the Maillard reaction. In this article, our current knowledge of asparagine in plants and in particular its occurrence in cereal seeds and potatoes is reviewed and discussed in relation to acrylamide formation. There is now clear evidence that soluble asparagine accumulates in most if not all plant organs during periods of low rates of protein synthesis and a plentiful supply of reduced nitrogen. The accumulation of asparagine occurs during normal physiological processes such as seed germination and nitrogen transport. However, in addition, stress-induced asparagine accumulation can be caused by mineral deficiencies, drought, salt, toxic metals and pathogen attack. The properties and gene regulation of the enzymes involved in asparagine synthesis and breakdown in plants are discussed in detail.

Third party logistics : a literature review and research agenda

Abstract: Purpose – To provide a taxonomy of third party logistics (3PL) research and, based on that, to develop a research agenda for this field of study.Design/methodology/approach – The proposed 3PL research classification framework is based on a comprehensive literature review, which concentrates on peer‐reviewed journal papers published within the period 1990‐2005. A total of 114 academic sources have been retrieved and analysed in terms of research purpose and nature, method employed, theoretical approach and level of analysis.Findings – The review reveals that 3PL research is empirical‐descriptive in nature and that it generally lacks a theoretical foundation. Survey research is the dominant method employed, reflecting the positivist research tradition within logistics. It identifies certain knowledge gaps and develops five propositions for future research. It suggests that focus should be directed towards more normative, theory‐driven and qualitative method‐based studies. It also argues that further empiric...

Strategy as Practice: Research Directions and Resources

Abstract: Preface Part I: 1. Introducing the Strategy as Practice Perspective: 2. Practical theories 3. Doing research on doing strategy Part II. Introduction to the Papers: 4. Technology as an occasion for structuring: evidence from observations of CT scanners and the social order of radiology departments Stephen R. Barley 5. Making fast strategic decisions in high-velocity environments Kathleen M. Eisenhardt 6. In search of rationality: the purposes behind the use of formal analysis in organizations Ann Langley 7. Sensemaking and sensegiving in strategic change initiation Dennis A. Gioia and Kumar Chittipeddi 8. Business planning as pedagogy: language and control in a changing institutional field Leslie S. Oakes, Barbara Townley and David J. Cooper 9. Strategizing as lived experience and strategists' everyday efforts to shape strategic direction Dalvir Samra-Fredericks 10. Organizational restructuring and middle manager sensemaking Julia Balogun and Gerry Johnson 11. From metaphor to practice in the crafting of strategy Peter T. Burgi, Claus D. Jacobs and Johan Roos Part III: 12. Reflections References.

Mental health of children and adolescents with intellectual disabilities in Britain

Abstract: Background Few studies have employed formal diagnostic criteria to determine the prevalence of psychiatric disorders in contemporaneous samples of children with and without intellectual disabilities. Aims To establish the prevalence of psychiatric disorders against ICD–10 criteria among children with and without intellectual disabilities, the association with social/environmental risk factors, and risk attributable to intellectual disability. Method Secondary analysis of the 1999 and 2004 Office for National Statistics surveys of the mental health of British children and adolescents with ( n =641) and without ( n =17 774) intellectual disability. Results Prevalence of psychiatric disorders was 36% among children with intellectual disability and 8% among children without (OR=6.5). Children with intellectual disabilities accounted for 14% of all British children with a diagnosable psychiatric disorder. Increased prevalence was particularly marked for autistic-spectrum disorder (OR=33.4), hyperkinesis (OR=8.4) and conduct disorders (OR=5.7). Cumulative risk of exposure to social disadvantage was associated with increased prevalence. Conclusions A significant proportion of the elevated risk for psychopathology among children with intellectual disability may be due to their increased rate of exposure to psychosocial disadvantage.

Rethinking Informed Consent in Bioethics

Abstract: 1 Consent: Nuremburg, Helsinki and beyond 2 Information and communication: the drift from agency 3 Informing and communicating: back to agency 4 How to rethink informed consent 5 Informational privacy and data protection 6 Genetic information and genetic exceptionalism 7 Trust, accountability and transparency Some conclusions and proposals

Coupling and ergodicity of adaptive markov chain monte carlo algorithms

Abstract: We consider basic ergodicity properties of adaptive Markov chain Monte Carlo algorithms under minimal assumptions, using coupling constructions. We prove convergence in distribution and a weak law of large numbers. We also give counterexamples to demonstrate that the assumptions we make are not redundant.

Complexity Theory, Systems Theory, and Multiple Intersecting Social Inequalities:

Abstract: This article contributes to the revision of the concept of system in social theory using complexity theory. The old concept of social system is widely discredited; a new concept of social system can more adequately constitute an explanatory framework. Complexity theory offers the toolkit needed for this paradigm shift in social theory. The route taken is not via Luhmann, but rather the insights of complexity theorists in the sciences are applied to the tradition of social theory inspired by Marx, Weber, and Simmel. The article contributes to the theorization of intersectionality in social theory as well as to the philosophy of social science. It addresses the challenge of theorizing the intersection of multiple complex social inequalities, exploring the various alternative approaches, before rethinking the concept of social system. It investigates and applies, for the first time, the implications of complexity theory for the analysis of multiple intersecting social inequalities.

Simulating entrepreneurial learning: integrating experiential and collaborative approaches to learning

Abstract: Theorizing about entrepreneurial learning is examined in this article to determine key learning processes within this body of research. It explores how these processes might be simulated in a stude...

Cross-national differences in relationships of work demands, job satisfaction, and turnover intentions with work-family conflict

Abstract: A study of work interference with family (WIF) among managers is described, contrasting four clusters of countries, one of which is individualistic (Anglo) and three of which are collectivistic (Asia, East Europe, and Latin America). Country cluster (Anglo vs. each of the others) moderated the relation of work demands with strain-based WIF, with the Anglo country cluster having the strongest relationships. Country cluster moderated some of the relationships of strain-based WIF with both job satisfaction and turnover intentions, with Anglos showing the strongest relationships. Cluster differences in domestic help were ruled out as the possible explanation for these moderator results.

A Taxonomy of Clutter Reduction for Information Visualisation

Abstract: Information visualisation is about gaining insight into data through a visual representation. This data is often multivariate and increasingly, the datasets are very large. To help us explore all this data, numerous visualisation applications, both commercial and research prototypes, have been designed using a variety of techniques and algorithms. Whether they are dedicated to geo-spatial data or skewed hierarchical data, most of the visualisations need to adopt strategies for dealing with overcrowded displays, brought about by too much data to fit in too small a display space. This paper analyses a large number of these clutter reduction methods, classifying them both in terms of how they deal with clutter reduction and more importantly, in terms of the benefits and losses. The aim of the resulting taxonomy is to act as a guide to match techniques to problems where different criteria may have different importance, and more importantly as a means to critique and hence develop existing and new techniques.

Exposure of electronics dismantling workers to polybrominated diphenyl ethers, polychlorinated biphenyls, and organochlorine pesticides in South China.

Abstract: In P.R. China, electronic waste (e-waste) from across the world is dismantled and discarded. Concentrations of polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), and organochlorine pesticides (OCPs) were measured in serum from residents of an e-waste dismantling region (Guiyu, South China), where 80% of families work in e-waste recycling, and compared to a matching cohort from a nearby region where the fishing industry dominates (Haojiang). Serum concentrations of PBDEs and OCPs, but not PCBs, were significantly different in the two regions: the median sigmaPBDE concentration was 3 times higher in Guiyu than Haojiang, whereas the opposite was true for dichloro-diphenyl-trichloroethane (DDT). PBDEs typically accounted for 46% of the total organohalogen chemicals in samples from Guiyu, but 8.7% in Haojiang. The median BDE-209 concentration in Guiyu was 50-200 times higher than previously reported in occupationally exposed populations. The highest BDE-209 concentration was 3100 ng/g lipid, the highest yet reported in humans. Serum PBDE concentrations did not correlate with PCBs or OCPs, whereas PCBs and OCPs showed positive correlations, suggesting that sources of PBDEs to humans are different from PCBs and OCPs. The levels of PBDEs in individuals from Haojiang are possibly related to the recycling activity at Guiyu, through atmospheric transport.

On-line inference for multiple changepoint problems

Abstract: We propose an on-line algorithm for exact filtering of multiple changepoint problems. This algorithm enables simulation from the true joint posterior distribution of the number and position of the changepoints for a class of changepoint models. The computational cost of this exact algorithm is quadratic in the number of observations. We further show how resampling ideas from particle filters can be used to reduce the computational cost to linear in the number of observations, at the expense of introducing small errors; and propose two new, optimum resampling algorithms for this problem. One, a version of rejection control, allows the particle filter to automatically choose the number of particles required at each time-step. The new resampling algorithms substantially out-perform standard resampling algorithms on examples we consider; and we demonstrate how the resulting particle filter is practicable for segmentation of human GC content.

Markets, market-making and marketing

Abstract: Recent debates in economic sociology have moved away from a critique to homo economicus to a focus on how market exchange is formalized and abstracted from social relations. Rather than dwell on the disparities between the formalism and the practice of market exchange, the work of Michel Callon and associates focuses on the calculating agencies that enable the creation and operation of markets. This article provides a critical examination of these ideas and argues that they have important implications for marketing theory, namely in terms of a shift from exchange as events to markets as institutions. Rather than regarding marketing practices as operating within pre-defined markets, we argue that marketing practices have a performative role in helping to create the phenomena they purportedly describe.

Carbon reduction, 'the public' and renewable energy: engaging with socio-technical configurations.

Abstract: In the context of challenging targets for renewable energy generation, this paper draws out social implications of moves towards low carbon energy systems. As renewable energy develops as a heterogeneous category, many potential forms of social relation between ‘publics’ and technologies are emerging. Utilising perspectives from science and technology studies, we outline five modes in which renewable energy has been implemented in the UK and how these involve different configurations of technology and social organisation. We argue that a multiplicity of roles for ‘the public’ are implicated across this increasingly complex landscape, cutting across established categories and raising questions of meaning, differentiation, interrelation and access. Policy assumptions and conceptions are questioned, highlighting that dominant characterisations of public roles have been part of a concentration on particular socio-technical pathways to the exclusion of others.

Public Participation in Science and Technology: Performing and Obscuring a Political–Conceptual Category Mistake

Abstract: In this paper, I attempt to explain how existing work in the science and technology studies (STS) sub-field of public engagement with, or participation in, public issues involving science and technology, has performed a serious category mistake in allowing itself to be called ‘public participation in science’ research. This requires us to reflect more systematically upon how our assumed objects, here the public issues we think we are dealing with, come to be ‘objectified’ in the forms which they do. Using the three sister papers, I make some conceptual distinctions which carry important political implications and corresponding analytical implications for STS. I suggest that the typical reduction of participation questions to ones of ‘what qualification do publics have for engagement in expert practices?’ is a mistaken distraction from more important questions which not only much analytical work, but also dominant practice, continues to ignore. This reductionist tendency even in social science and STS may tend to intensify, the more the issues reach across global networks and arenas. Finally, I suggest that STS work on public participation needs to enrich itself with some relevant political theory and philosophy, which would throw due historical perspective on the deeper forces shaping scientific understandings and normative representational performances of its ‘democratic’ publics.

From margins to centre: a review of the history of palliative care in cancer

Abstract: Palliative care and hospices have developed rapidly since the late 1960s. The pioneering work of Cicely Saunders was instrumental in drawing attention to the end-of-life care needs of patients with advanced malignant disease. Palliative care began to be defined as a subject of activity in the 1970s and came to be synonymous with the physical, social, psychological, and spiritual support of patients with life-limiting illness, delivered by a multidisciplinary team. Palliative care services have developed in many settings and have often been closely related to oncology. The worldwide need for this type of care remains much greater than the available provision, but there are encouraging signs of recognition by policymakers and influential bodies, and interest in palliative care has never been greater. This paper charts the modern history of such care around the world and concludes on some current issues and future challenges.

Understanding the biodiversity consequences of habitat change: the value of secondary and plantation forests for neotropical dung beetles

Abstract: 1. Secondary and plantation forests are becoming increasingly widespread in the tropics. A recent meta-analysis on the impacts of land-use change on tropical forest dung beetles concluded that regenerating forests can be effective in helping to offset species loss following deforestation. However, our understanding of the extent to which these results can be generalized to new locations remains very poor. 2. We attempted to overcome many of the design limitations that characterize previous studies by collecting spatially independent dung beetle samples from primary, secondary and Eucalyptus plantation forests in north-east Brazilian Amazonia across a large quasi-experimental landscape that minimized confounding edge and fragmentation effects. 3. We recorded 9203 dung beetles, comprising 85 species. Species richness was significantly higher in primary forest and the majority of species were more abundant there than elsewhere, whereas secondary and plantation sites harboured an impoverished subset of primary forest species. 4. Our data illustrate the low value of tropical secondary and plantation forests for dung beetles in our study area, and our conclusions are more pessimistic than those of earlier studies. 5. Because of differences in the order of species rank-abundance and rank-biomass patterns, re-coding community data from abundance to biomass significantly altered the analytical weight of individual species in determining community patterns. Larger bodied beetles were more prone to local extinctions and abundance declines and this effect was consistent both within and between genera. 6. Synthesis and applications. Our study demonstrates that secondary and plantation forests in a large neotropical landscape host exceptionally impoverished dung beetle communities. Furthermore, the depletion of beetle abundance combined with a reduction in average body mass in converted forests is likely to have detrimental consequences for the maintenance of dung beetle-mediated ecosystem services in these habitats. Differences in biogeographical and landscape context, and the influence of common limitations in sampling design, may explain why many other studies have painted a more optimistic picture of the conservation value of anthropogenic habitats. In the absence of further evidence we caution strongly against the claim that forest regeneration schemes on degraded land can effectively offset the loss of species following deforestation, and urge that conservation strategies prioritize the protection of remaining areas of primary forest.