Lehigh University

About: Lehigh University is a education organization based out in Bethlehem, Pennsylvania, United States. It is known for research contribution in the topics: Catalysis & Fracture mechanics. The organization has 12684 authors who have published 26550 publications receiving 770061 citations.

The Effects of Child Abuse and Exposure to Domestic Violence on Adolescent Internalizing and Externalizing Behavior Problems.

Abstract: This study examines the effects of child abuse and domestic violence exposure in childhood on adolescent internalizing and externalizing behaviors Data for this analysis are from the Lehigh Longitudinal Study, a prospective study of 457 youth addressing outcomes of family violence and resilience in individuals and families Results show that child abuse, domestic violence, and both in combination (ie, dual exposure) increase a child’s risk for internalizing and externalizing outcomes in adolescence When accounting for risk factors associated with additional stressors in the family and surrounding environment, only those children with dual exposure had an elevated risk of the tested outcomes compared to non-exposed youth However, while there were some observable differences in the prediction of outcomes for children with dual exposure compared to those with single exposure (ie, abuse only or exposure to domestic violence only), these difference were not statistically significant Analyses showed that the effects of exposure for boys and girls are statistically comparable

Atomic-layered Au clusters on α-MoC as catalysts for the low-temperature water-gas shift reaction

Abstract: The water-gas shift (WGS) reaction (where carbon monoxide plus water yields dihydrogen and carbon dioxide) is an essential process for hydrogen generation and carbon monoxide removal in various energy-related chemical operations. This equilibrium-limited reaction is favored at a low working temperature. Potential application in fuel cells also requires a WGS catalyst to be highly active, stable, and energy-efficient and to match the working temperature of on-site hydrogen generation and consumption units. We synthesized layered gold (Au) clusters on a molybdenum carbide (α-MoC) substrate to create an interfacial catalyst system for the ultralow-temperature WGS reaction. Water was activated over α-MoC at 303 kelvin, whereas carbon monoxide adsorbed on adjacent Au sites was apt to react with surface hydroxyl groups formed from water splitting, leading to a high WGS activity at low temperatures.

Target Localization Accuracy Gain in MIMO Radar-Based Systems

Abstract: This paper presents an analysis of target localization accuracy, attainable by the use of multiple-input multiple-output (MIMO) radar systems, configured with multiple transmit and receive sensors, widely distributed over an area. The Cramer-Rao lower bound (CRLB) for target localization accuracy is developed for both coherent and noncoherent processing. Coherent processing requires a common phase reference for all transmit and receive sensors. The CRLB is shown to be inversely proportional to the signal effective bandwidth in the noncoherent case, but is approximately inversely proportional to the carrier frequency in the coherent case. We further prove that optimization over the sensors' positions lowers the CRLB by a factor equal to the product of the number of transmitting and receiving sensors. The best linear unbiased estimator (BLUE) is derived for the MIMO target localization problem. The BLUE's utility is in providing a closed-form localization estimate that facilitates the analysis of the relations between sensors locations, target location, and localization accuracy. Geometric dilution of precision (GDOP) contours are used to map the relative performance accuracy for a given layout of radars over a given geographic area.

Nanomolar concentrations of nocodazole alter microtubule dynamic instability in vivo and in vitro.

Abstract: Previous studies demonstrated that nanomolar concentrations of nocodazole can block cells in mitosis without net microtubule disassembly and resulted in the hypothesis that this block was due to a nocodazole-induced stabilization of microtubules. We tested this hypothesis by examining the effects of nanomolar concentrations of nocodazole on microtubule dynamic instability in interphase cells and in vitro with purified brain tubulin. Newt lung epithelial cell microtubules were visualized by video-enhanced differential interference contrast microscopy and cells were perfused with solutions of nocodazole ranging in concentration from 4 to 400 nM. Microtubules showed a loss of the two-state behavior typical of dynamic instability as evidenced by the addition of a third state where they exhibited little net change in length (a paused state). Nocodazole perfusion also resulted in slower elongation and shortening velocities, increased catastrophe, and an overall decrease in microtubule turnover. Experiments performed on BSC-1 cells that were microinjected with rhodamine-labeled tubulin, incubated in nocodazole for 1 h, and visualized by using low-light-level fluorescence microscopy showed similar results except that nocodazole-treated BSC-1 cells showed a decrease in catastrophe. To gain insight into possible mechanisms responsible for changes in dynamic instability, we examined the effects of 4 nM to 12 microM nocodazole on the assembly of purified tubulin from axoneme seeds. At both microtubule plus and minus ends, perfusion with nocodazole resulted in a dose-dependent decrease in elongation and shortening velocities, increase in pause duration and catastrophe frequency, and decrease in rescue frequency. These effects, which result in an overall decrease in microtubule turnover after nocodazole treatment, suggest that the mitotic block observed is due to a reduction in microtubule dynamic turnover. In addition, the in vitro results are similar to the effects of increasing concentrations of GDP-tubulin (TuD) subunits on microtubule assembly. Given that nocodazole increases tubulin GTPase activity, we propose that nocodazole acts by generating TuD subunits that then alter dynamic instability.