Institution
Lehigh University
Education•Bethlehem, Pennsylvania, United States•
About: Lehigh University is a education organization based out in Bethlehem, Pennsylvania, United States. It is known for research contribution in the topics: Catalysis & Fracture mechanics. The organization has 12684 authors who have published 26550 publications receiving 770061 citations.
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TL;DR: In this article, the authors adopt a multi-dimensional view of absorptive capacity and focus specifically on the application of external knowledge that has been obtained via university-firm collaborations and examine various organizational conditions that influence a firm's ability to apply external knowledge for explorative and exploitative innovations.
Abstract: A firm's ability to acquire and exploit external knowledge is often critical to achieving and sustaining a competitive advantage. In this study, we adopt a multi-dimensional view of absorptive capacity and focus specifically on the application of external knowledge that has been obtained via university-firm collaborations. We examine various organizational conditions that we propose influence a firm's ability to apply external knowledge for explorative and exploitative innovations. We collected data by a survey of firms in industries that frequently work with university research centres (URCs) and from publicly available sources. Results show that predictors of exploration and exploitation of the application of external knowledge differ. Surprisingly, technological relatedness, a common measure of absorptive capacity, is negatively associated with the application of external knowledge to explorative innovations, indicating that knowledge from more distant sources is applied more to exploration. Results also indicate that the effects of two external learning capabilities (prior experience with URCs and technological capability) on knowledge application are moderated in such a way by the tacitness of the knowledge transferred that experience is a stronger predictor when the knowledge is more explicit and technological capability is a stronger predictor when the knowledge is more tacit. We discuss the implications of these findings for research on the application of external knowledge.
397 citations
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TL;DR: The authors examined the emotional and behavioral consequences of making functional versus hedonic trade-offs and found that consumers attach greater importance to the hedonics attribute than the functional attribute in choice tasks.
Abstract: This article examines the emotional and behavioral consequences of making functional versus hedonic trade-offs. Building on the proposed correspondence between functionality and a prevention focus and between hedonics and a promotion focus, the authors predict that contexts involving functional versus hedonic trade-offs evoke a variety of both negative and positive emotions, including guilt/anxiety, sadness/disappointment, cheerfulness/excitement, and confidence/security. These predictions are confirmed. Furthermore, an analysis of the intensities of these specific emotions reveals the following additional insights: (1) Under conditions in which the options in a choice set meet or exceed both functional and hedonic cutoffs, consumers attach greater importance to the hedonic attribute, and (2) whereas the functionally superior option is preferred in choice tasks, the hedonically superior one is preferred in willingness-to-pay tasks.
397 citations
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TL;DR: It is demonstrated that heterogeneous interactions involving all residue types underlie LLPS of human FUS LC, and it is shown that hydrogen bonding, π/sp2, and hydrophobic interactions all contribute to stabilizingLLPS of F US LC.
Abstract: The low-complexity domain of the RNA-binding protein FUS (FUS LC) mediates liquid-liquid phase separation (LLPS), but the interactions between the repetitive SYGQ-rich sequence of FUS LC that stabilize the liquid phase are not known in detail. By combining NMR and Raman spectroscopy, mutagenesis, and molecular simulation, we demonstrate that heterogeneous interactions involving all residue types underlie LLPS of human FUS LC. We find no evidence that FUS LC adopts conformations with traditional secondary structure elements in the condensed phase; rather, it maintains conformational heterogeneity. We show that hydrogen bonding, π/sp2, and hydrophobic interactions all contribute to stabilizing LLPS of FUS LC. In addition to contributions from tyrosine residues, we find that glutamine residues also participate in contacts leading to LLPS of FUS LC. These results support a model in which FUS LC forms dynamic, multivalent interactions via multiple residue types and remains disordered in the densely packed liquid phase.
397 citations
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Lewis & Clark College1, Brigham Young University2, North Carolina State University3, University of Maryland, Baltimore County4, Purdue University5, Calvin College6, City University of New York7, Oregon State University8, Cabrini College9, Washington University in St. Louis10, University of Louisiana at Monroe11, University of Colorado Boulder12, University of California, Santa Cruz13, North Carolina Central University14, University of North Texas15, Virginia Commonwealth University16, Western Kentucky University17, University of Mary Washington18, Indiana University – Purdue University Indianapolis19, University of Montana20, University of Puerto Rico at Cayey21, College of William & Mary22, James Madison University23, Lehigh University24, Howard Hughes Medical Institute25, University of Pittsburgh26, Grinnell College27
TL;DR: A general model in which faculty and teaching assistants from diverse academic institutions are trained to teach a research course for first-year undergraduate students focused on bacteriophage discovery and genomics is developed, showing that this alliance-sourced model not only substantially advances the field of phage genomics but also stimulates students’ interest in science, positively influences academic achievement, and enhances persistence inScience, technology, engineering, and mathematics (STEM) disciplines.
Abstract: Engaging large numbers of undergraduates in authentic scientific discovery is desirable but difficult to achieve. We have developed a general model in which faculty and teaching assistants from diverse academic institutions are trained to teach a research course for first-year undergraduate students focused on bacteriophage discovery and genomics. The course is situated within a broader scientific context aimed at understanding viral diversity, such that faculty and students are collaborators with established researchers in the field. The Howard Hughes Medical Institute (HHMI) Science Education Alliance Phage Hunters Advancing Genomics and Evolutionary Science (SEA-PHAGES) course has been widely implemented and has been taken by over 4,800 students at 73 institutions. We show here that this alliance-sourced model not only substantially advances the field of phage genomics but also stimulates students’ interest in science, positively influences academic achievement, and enhances persistence in science, technology, engineering, and mathematics (STEM) disciplines. Broad application of this model by integrating other research areas with large numbers of early-career undergraduate students has the potential to be transformative in science education and research training. IMPORTANCE Engagement of undergraduate students in scientific research at early stages in their careers presents an opportunity to excite students about science, technology, engineering, and mathematics (STEM) disciplines and promote continued interests in these areas. Many excellent course-based undergraduate research experiences have been developed, but scaling these to a broader impact with larger numbers of students is challenging. The Howard Hughes Medical Institute (HHMI) Science Education Alliance Phage Hunting Advancing Genomics and Evolutionary Science (SEA-PHAGES) program takes advantage of the huge size and diversity of the bacteriophage population to engage students in discovery of new viruses, genome annotation, and comparative genomics, with strong impacts on bacteriophage research, increased persistence in STEM fields, and student self-identification with learning gains, motivation, attitude, and career aspirations.
396 citations
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TL;DR: In this paper, the effects of carbon dioxide on the catalytic synthesis of methanol over the copper-zinc oxide catalysts were investigated for CO2/CO/H2 ratios between 0/30/70 and 30/0/70.
389 citations
Authors
Showing all 12785 results
Name | H-index | Papers | Citations |
---|---|---|---|
Yang Yang | 171 | 2644 | 153049 |
Gang Chen | 167 | 3372 | 149819 |
Yi Yang | 143 | 2456 | 92268 |
Mark D. Griffiths | 124 | 1238 | 61335 |
Michael Gill | 121 | 810 | 86338 |
Masaki Mori | 110 | 2200 | 66676 |
Kai Nan An | 109 | 953 | 51638 |
James R. Rice | 108 | 278 | 68943 |
Vinayak P. Dravid | 103 | 817 | 43612 |
Andrew M. Jones | 103 | 764 | 37253 |
Israel E. Wachs | 103 | 427 | 32029 |
Demetrios N. Christodoulides | 100 | 704 | 51093 |
Bert M. Weckhuysen | 100 | 767 | 40945 |
José Luis García Fierro | 100 | 1027 | 47228 |
Mordechai Segev | 99 | 729 | 40073 |