Showing papers by "Leibniz University of Hanover published in 2006"

Laplace-Beltrami spectra as 'Shape-DNA' of surfaces and solids

Abstract: This paper introduces a method to extract 'Shape-DNA', a numerical fingerprint or signature, of any 2d or 3d manifold (surface or solid) by taking the eigenvalues (i.e. the spectrum) of its Laplace-Beltrami operator. Employing the Laplace-Beltrami spectra (not the spectra of the mesh Laplacian) as fingerprints of surfaces and solids is a novel approach. Since the spectrum is an isometry invariant, it is independent of the object's representation including parametrization and spatial position. Additionally, the eigenvalues can be normalized so that uniform scaling factors for the geometric objects can be obtained easily. Therefore, checking if two objects are isometric needs no prior alignment (registration/localization) of the objects but only a comparison of their spectra. In this paper, we describe the computation of the spectra and their comparison for objects represented by NURBS or other parametrized surfaces (possibly glued to each other), polygonal meshes as well as solid polyhedra. Exploiting the isometry invariance of the Laplace-Beltrami operator we succeed in computing eigenvalues for smoothly bounded objects without discretization errors caused by approximation of the boundary. Furthermore, we present two non-isometric but isospectral solids that cannot be distinguished by the spectra of their bodies and present evidence that the spectra of their boundary shells can tell them apart. Moreover, we show the rapid convergence of the heat trace series and demonstrate that it is computationally feasible to extract geometrical data such as the volume, the boundary length and even the Euler characteristic from the numerically calculated eigenvalues. This fact not only confirms the accuracy of our computed eigenvalues, but also underlines the geometrical importance of the spectrum. With the help of this Shape-DNA, it is possible to support copyright protection, database retrieval and quality assessment of digital data representing surfaces and solids. A patent application based on ideas presented in this paper is pending.

Angiogenesis in tissue engineering: breathing life into constructed tissue substitutes.

Abstract: Long-term function of three-dimensional (3D) tissue constructs depends on adequate vascularization after implantation. Accordingly, research in tissue engineering has focused on the analysis of angiogenesis. For this purpose, 2 sophisticated in vivo models (the chorioallantoic membrane and the dorsal skinfold chamber) have recently been introduced in tissue engineering research, allowing a more detailed analysis of angiogenic dysfunction and engraftment failure. To achieve vascularization of tissue constructs, several approaches are currently under investigation. These include the modification of biomaterial properties of scaffolds and the stimulation of blood vessel development and maturation by different growth factors using slow-release devices through pre-encapsulated microspheres. Moreover, new microvascular networks in tissue substitutes can be engineered by using endothelial cells and stem cells or by creating arteriovenous shunt loops. Nonetheless, the currently used techniques are not sufficient to induce the rapid vascularization necessary for an adequate cellular oxygen supply. Thus, future directions of research should focus on the creation of microvascular networks within 3D tissue constructs in vitro before implantation or by co-stimulation of angiogenesis and parenchymal cell proliferation to engineer the vascularized tissue substitute in situ.

An intercomparison of large-eddy simulations of the stable boundary layer

Abstract: Results are presented from the first intercomparison of large-eddy simulation (LES) models for the stable boundary layer (SBL), as part of the Global Energy and Water Cycle Experiment Atmospheric Boundary Layer Study initiative. A moderately stable case is used, based on Arctic observations. All models produce successful simulations, in as much as they generate resolved turbulence and reflect many of the results from local scaling theory and observations. Simulations performed at 1-m and 2-m resolution show only small changes in the mean profiles compared to coarser resolutions. Also, sensitivity to subgrid models for individual models highlights their importance in SBL simulation at moderate resolution (6.25 m). Stability functions are derived from the LES using typical mixing lengths used in numerical weather prediction (NWP) and climate models. The functions have smaller values than those used in NWP. There is also support for the use of K-profile similarity in parametrizations. Thus, the results provide improved understanding and motivate future developments of the parametrization of the SBL.

Introduction: Sociolinguistics and computer-mediated communication

Abstract: This theme issue of Journal of Sociolinguistics comprises a number of empirical studies focusing on a range of ways in which people use language in computer-mediated communication (CMC). This introduction contextualizes the contributions to this issue by providing an outline of linguistically focused CMC studies. A critique of the research on the ‘language of CMC’ is given, and aspects of CMC research from a sociolinguistic viewpoint are presented: the move from the ‘language of CMC’ to socially situated computer-mediated discourse; its grounding in the notion of online community; and the application of sociolinguistic methodologies to its study. It is argued that CMC provides a new empirical arena for various research traditions in sociolinguistics; conversely, sociolinguistics can contribute to the interdisciplinary theorizing of CMC by demonstrating the role of language use and linguistic variability in the construction of interpersonal relationships and social identities on the Internet.

Effects of a cinnamon extract on plasma glucose, HbA1c, and serum lipids in diabetes mellitus type 2

Abstract: Background According to previous studies, cinnamon may have a positive effect on the glycaemic control and the lipid profile in patients with diabetes mellitus type 2. The aim of this trial was to determine whether an aqueous cinnamon purified extract improves glycated haemoglobin A1c (HbA 1c ), fasting plasma glucose, total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL) and triacylglycerol concentrations in patients with type 2 diabetes. Methods A total of 79 patients with diagnosed diabetes mellitus type 2 not on insulin therapy but treated with oral antidiabetics or diet were randomly assigned to take either a cinnamon extract or a placebo capsule three times a day for 4 months in a double-blind study. The amount of aqueous cinnamon extract corresponded to 3 g of cinnamon powder per day. Results The mean absolute and percentage differences between the pre- and postintervention fasting plasma glucose level of the cinnamon and placebo groups were significantly different. There was a significantly higher reduction in the cinnamon group (10·3%) than in the placebo group (3·4%). No significant intragroup or intergroup differences were observed regarding HbA 1c , lipid profiles or differences between the pre- and postintervention levels of these variables. The decrease in plasma glucose correlated significantly with the baseline concentrations, indicating that subjects with a higher initial plasma glucose level may benefit more from cinnamon intake. No adverse effects were observed.

Imaging of acute stroke

Abstract: Summary Thrombolytic therapy has led to a higher proportion of patients presenting to hospital early, and this, with parallel developments in imaging technology, has greatly improved the understanding of acute stroke pathophysiology. Additionally, MRI, including diffusion-weighted imaging (DWI) and gradient echo, or T2*, imaging is important in understanding basic structural information—such as distinguishing acute ischaemia from haemorrhage. It has also greatly increased sensitivity in the diagnosis of acute cerebral ischaemia. The pathophysiology of the ischaemic penumbra can now be assessed with CT or MRI-based perfusion imaging techniques, which are widely available and clinically applicable. Pathophysiological information from CT or MRI increasingly helps clinical trial design, may allow targeted therapy in individual patients, and may extend the time scale for reperfusion therapy.

Combining enabling techniques in organic synthesis: continuous flow processes with heterogenized catalysts.

Abstract: The concepts article describes enabling techniques (solid-phase assisted synthesis, new reactor design, microwave irradiation and new solvents) in organic chemistry and emphasizes the combination of several of them for creating new synthetic technology platforms. Particular focus is put on the combination of immobilized catalysts as well as biocatalysts with continuous flow processes. In this context, the PASSflow continuous flow technique fulfils both chemical as well as chemical engineering requirements. It combines reactor design with optimized, monolithic solid phases as well as reversible immobilization techniques for performing small as well as large scale synthesis with heterogenized catalysts under continuous flow conditions.

Global Existence and Blow-Up Phenomena for the Degasperis-Procesi Equation

Abstract: This paper is concerned with several aspects of the existence of global solutions and the formation of singularities for the Degasperis-Procesi equation on the line. Global strong solutions to the equation are determined for a class of initial profiles. On the other hand, it is shown that the first blow-up can occur only in the form of wave-breaking. A new wave-breaking mechanism for solutions is described in detail and two results of blow-up solutions with certain initial profiles are established.

Characterization of aqueous pores in plant cuticles and permeation of ionic solutes

Abstract: Plant cuticles are lipid membranes with separate diffusion paths for lipophilic non-electrolytes and hydrated ionic compounds. Ions are lipid insoluble and require an aqueous pathway across cuticles. Based on experimental data, the aqueous pathway in cuticles has been characterized. Aqueous pores arise by hydration of permanent dipoles and ionic functional groups. They can be localized using ionic fluorescent dyes, silver nitrate, and mercuric chloride. Aqueous pores preferentially occur in cuticular ledges, at the base of trichomes, and in cuticles over anticlinal walls. Average pore radii ranged from 0.45 to 1.18 nm. Penetration of ions was a first order process as the fraction of the salt remaining on the cuticle surface decreased exponentially with time. Permeability of cuticles to ions depended on humidity and was highest at 100% humidity. Wetting agents increased rate constants by factors of up to 12, which indicates that the pore openings are surrounded by waxes. The pores in cuticular ledges of Helxine soleirolii allowed passage of berberine sulphate, which has a molecular weight of 769 g mol(-1). Increasing the molecular weight of solutes from 100 to 500 g mol(-1) decreased the rate constants of penetration by factors of 7 (Vicia faba) and 13 (Populus canescens), respectively. Half-times of penetration of inorganic salts and organic ions across Populus cuticles and Vicia leaf surfaces varied between 1 and 12 h. This shows that penetration of ionic compounds can be fairly rapid, and ions with molecular weights of up to 800 g mol(-1) can penetrate cuticles that possess aqueous pores.

Consumer Power: A Comparison of the Old Economy and the Internet Economy

Abstract: From the very beginning of the Internet, a decisive shift from supplier power to consumer power was predicted by several authors and is still maintained in recent literature. Although the Internet has grown rapidly within the last years and electronic markets have evolved, a theoretical framework for consumer power on the Internet still cannot be identified. Few authors have taken efforts to apply common concepts of power theory to the characteristics of the Internet. Based on the concept of French and Raven, this paper analyses consumer power in traditional markets and then compares it to the situation on the Internet. This comparison shows that the Internet enables consumers (a) to overcome most information asymmetries that characterize traditional consumer markets and thus obtain high levels of market transparency, (b) to easily band together against companies and impose sanctions via exit and voice, and (c) to take on a more active role in the value chain and influence products and prices according to individual preferences. A broad literature review reveals that empirical findings confirm these hypotheses to a great extent. The authors conclude by summarizing the results and drawing implications from two different angles, namely from a marketing and a consumer policy perspective.

A systematic review on the diagnosis and treatment of primary (idiopathic) dystonia and dystonia plus syndromes: report of an EFNS/MDS-ES Task Force

Abstract: To review the literature on primary dystonia and dystonia plus and to provide evidence-based recommendations. Primary dystonia and dystonia plus are chronic and often disabling conditions with a widespread spectrum mainly in young people. Computerized MEDLINE and EMBASE literature reviews (1966-1967 February 2005) were conducted. The Cochrane Library was searched for relevant citations. Diagnosis and classification of dystonia are highly relevant for providing appropriate management and prognostic information, and genetic counselling. Expert observation is suggested. DYT-1 gene testing in conjunction with genetic counselling is recommended for patients with primary dystonia with onset before age 30 years and in those with an affected relative with early onset. Positive genetic testing for dystonia (e.g. DYT-1) is not sufficient to make diagnosis of dystonia. Individuals with myoclonus should be tested for the epsilon-sarcoglycan gene (DYT-11). A levodopa trial is warranted in every patient with early onset dystonia without an alternative diagnosis. Brain imaging is not routinely required when there is a confident diagnosis of primary dystonia in adult patients, whereas it is necessary in the paediatric population. Botulinum toxin (BoNT) type A (or type B if there is resistance to type A) can be regarded as first line treatment for primary cranial (excluding oromandibular) or cervical dystonia and can be effective in writing dystonia. Actual evidence is lacking on direct comparison of the clinical efficacy and safety of BoNT-A vs. BoNT-B. Pallidal deep brain stimulation (DBS) is considered a good option, particularly for generalized or cervical dystonia, after medication or BoNT have failed to provide adequate improvement. Selective peripheral denervation is a safe procedure that is indicated exclusively in cervical dystonia. Intrathecal baclofen can be indicated in patients where secondary dystonia is combined with spasticity. The absolute and comparative efficacy and tolerability of drugs in dystonia, including anticholinergic and antidopaminergic drugs, is poorly documented and no evidence-based recommendations can be made to guide prescribing.

Effect of water on tholeiitic basalt phase equilibria: an experimental study under oxidizing conditions

Abstract: To investigate the effect of water on phase relations and compositions in a basaltic system, we performed crystallization experiments at pressures of 100, 200 and 500 MPa in a temperature range of 940 to 1,220°C using four different water contents. Depending on the water activity, the oxygen fugacity varied between 1 and 4 log units above the quartz-magnetite-fayalite buffer. Addition of water to the dry system shifts the solidus > 250°C to lower temperatures and increases the amount of melt drastically. For instance, at 1,100°C and 200 MPa, the melt fraction increases from 12.5 wt% at a water content of 1.6 wt% to 96.3% at a water content of 5 wt% in the melt. The compositions of the experimental phases also show a strong effect of water. Plagioclase is shifted to higher anorthite contents by the addition of water. Olivine and clinopyroxene show generally higher MgO/FeO ratios with added water, which could also be related to the increasing oxygen fugacity with water. Moreover, water affects the partitioning of certain elements between minerals and melts, e.g., the Ca partitioning between olivine and melt. Plagioclase shows a characteristic change in the order of crystallization with water that may help to explain the formation of wehrlites intruding the lower oceanic crust (e.g., in Oman, Macquarie Island). At 100 MPa, plagioclase crystallizes before clinopyroxene at all water contents. At pressures > 100 MPa, plagioclase crystallizes before clinopyroxene at low water contents (e.g. 3 wt%. This change in crystallization order indicates that a paragenesis typical for wehrlites (olivine–clinopyroxene–without plagioclase) is stabilized at low pressures typical of the oceanic crust only at high water contents. This opens the possibility that typical wehrlites in the oceanic crust can be formed by the fractionation and accumulation of olivine and clinopyroxene at 1,060°C and > 100 MPa in a primitive tholeiitic basaltic system containing more than 3 wt% water. The comparison of the experimental results with evolution trends calculated by the thermodynamic models “MELTS” and “Comagmat” shows that neither model predicts the experimental phase relations with sufficient accuracy.

Room‐Temperature Synthesis of Porous Nanoparticulate TiO2 Films for Flexible Dye‐Sensitized Solar Cells

Abstract: A novel room-temperature method for the preparation of porous TiO2 films with high performance in dye-sensitized solar cells (DSSCs) has been developed. In this method a small amount of TiIV tetraisopropoxide (TTIP) is added to an ethanolic paste of TiO2 nanoparticles, where it hydrolyzes in situ and connects the TiO2 particles to form a homogenous and mechanically stable film of up to 10 μm thickness without crack formation. Residual organics originating from the TTIP were removed by UV–ozone treatment of the films, leading to a remarkable improvement of the cell efficiency. Intensity-modulated photocurrent/voltage spectroscopy (IMPS/IMVS) showed that the main effect of the UV–ozone treatment is to suppress the recombination of photogenerated electrons, thereby extending their lifetime. The efficiency was further increased by preheating the TiO2 nanoparticles before the paste preparation to remove contaminants originating from the preparation process of the particles. Solar-to-electric energy conversion efficiencies of 4.00 and 3.27 % have been achieved for cells with conductive glass and plastic film substrates, respectively, under illumination with AM 1.5 (100 mW cm–2) simulated sunlight.

Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1

Abstract: Tight regulation of transcription factors, such as PU.1, is crucial for generation of all hematopoietic lineages. We previously reported that mice with a deletion of an upstream regulatory element (URE) of the gene encoding PU.1 (Sfpi1) developed acute myeloid leukemia. Here we show that the URE has an essential role in orchestrating the dynamic PU.1 expression pattern required for lymphoid development and tumor suppression. URE deletion ablated B2 cells but stimulated growth of B1 cells in mice. The URE was a PU.1 enhancer in B cells but a repressor in T cell precursors. TCF transcription factors coordinated this repressor function and linked PU.1 to Wnt signaling. Failure of appropriate PU.1 repression in T cell progenitors with URE deletion disrupted differentiation and induced thymic transformation. Genome-wide DNA methylation assessment showed that epigenetic silencing of selective tumor suppressor genes completed PU.1-initiated transformation of lymphoid progenitors with URE deletion. These results elucidate how a single transcription factor, PU.1, through the cell context-specific activity of a key cis-regulatory element, affects the development of multiple cell lineages and can induce cancer.

How do corporate reputation and customer satisfaction impact customer defection? A study of private energy customers in Germany

Abstract: Purpose – To analyze whether perceived corporate reputation and customer satisfaction are directly associated with customer intention.Design/methodology/approach – Using structural equation modeling, the study is based on the responses to a written questionnaire of 462 customers of a large German utility.Findings – A non‐significant and weak relationship was found between corporate reputation and switching intention. The postulated impact of customer satisfaction on customer switching intention was confirmed. Corporate reputation and customer satisfaction were found to be strongly correlated.Research limitations/implications – The sample includes only one company's customers, so the findings may not be generalized to other industries. Future research in other service industries is called for.Practical implications – The threat of customer defection in deregulated markets requires power supply companies to examine the marketing instruments and measures required to inhibit customer willingness to switch pow...

Highly crystalline WO3 thin films with ordered 3D mesoporosity and improved electrochromic performance.

Abstract: WO3 thin layers with nanometer-scale periodicity were prepared by evaporation-induced self-assembly (EISA) using a novel amphiphilic block-copolymer template (poly(ethylene-co-butylene)-block-poly(ethylene oxide)). The evolution of the mesoporous ordered network and the crystallinity of the framework were monitored by 2D-SAXS, WAXS, SEM, XPS, and porosimetry. By annealing the films, the pore-wall crystallinity is adjusted between fully amorphous and highly crystalline without mesostructural degradation. Thus, the crystalline-film framework is composed of phase-pure monoclinic WO3 nanoparticles (12-14 nm in size). Furthermore, heat treatment transforms the originally spherical mesopores into ellipsoids, resulting in a unidirectionally shrunken, but still well-defined and fully accessible bcc mesopore architecture. The influence of mesoporosity and crystallinity on electrochemical/electrochromic characteristics was addressed by monitoring electrochemical features and the absorption changes during Li insertion/extraction (repetitive potentiostatic cycling). Both the amorphous and crystalline mesoporous films possess electrochromic response times on the order of only seconds, which are attributable to the facilitated insertion of guest ions due to shortening of the diffusion path lengths. Also, the insertion/extraction reversibility of crystalline WO3 layers with 3D mesoporosity is improved compared to amorphous ones and reaches values close to 100%.

Towards a generic observer/controller architecture for Organic Computing.

Abstract: Technical scenarios in areas like automotive or production systems will increasingly consist of a large number of components cooperating in potentially unlimited and dynamically changing networks to satisfy the functional requirements of their execution environment. Due to the high complexity it will be impossible to explicitly design the behaviour of the components for every potentially arising situation. Therefore, it will be necessary to leave an adequate degree of freedom allowing for a self-organised behaviour. Organic Computing (OC) has developed the vision of selforganising systems adapting robustly to dynamically changing environments without running out of control. This paper focuses on the design of a generic system architecture which allows for self-organisation but at the same time enables adequate reactions to control the – sometimes completely unexpected – emerging global behaviour of these self-organised technical systems.

Nonequilibrium Cation Distribution, Canted Spin Arrangement, and Enhanced Magnetization in Nanosized MgFe2O4 Prepared by a One-Step Mechanochemical Route

Abstract: A single-step synthesis of magnesium ferrite (MgFe2O4) nanoparticles with an average crystallite size of about 8.5 nm synthesized via mechanochemical processing of binary oxide precursors at room temperature is reported. The study highlights the nature of the cation disorder and of the spin arrangement in mechanosynthesized MgFe2O4 as well as its response to changes in temperature. An unusual property of the magnetization enhancement in nanoscale mechanosynthesized MgFe2O4 is reported. Whereas the inner core of a MgFe2O4 nanoparticle exhibits a partly inverse spinel structure with a Neel type collinear spin alignment, the major features of the ionic and spin configurations in the grain boundary (surface) region are a nonequilibrium cation distribution and a canted spin arrangement. Although the spin-canting effect tends to reduce the magnetic moment, the magnetization enhancement exhibited by mechanosynthesized MgFe2O4 is attributed to the nearly random distribution of magnetic cations in the surface regi...

Extended evidence on the use of technical analysis in foreign exchange

Abstract: This work extends earlier survey studies on the use of technical analysis by considering flow analysis as a third form of information production. Moreover, the survey covers FX dealers and also the rising fund managers. Technical analysis has gained importance over time and is now the most equally spread kind of analysis. It has by far the greatest importance in FX dealing and is second in fund management. Charts are used for shorter-term forecasting horizons while flows dominate at the shortest-term and fundamentals at longer horizons. Preferred users of each kind of analysis exhibit different views about market frictions. Copyright # 2006 John Wiley & Sons, Ltd.

Coffee berry borer Hypothenemus hampei (Coleoptera: Curculionidae): searching for sustainable control strategies.

Abstract: The coffee berry borer Hypothenemus hampei (Ferrari) is the most serious pest of the world's most valuable tropical export crop Since the last review on this insect was published six years ago, many new studies have contributed to an improved insight into the biology and ecology of the beetle, and have indicated new avenues for integrated and biological control The latest developments in research, both laboratory and field, on the pest, its natural enemies and their implications for integrated control of H hampei are summarized, with a particular focus on the situation in The Americas Lately, the global coffee industry has changed radically; it has suffered a long cycle of lowest-ever world market prices caused by overproduction and technological change At the same time, the advent of sustainable certification schemes has had a major impact on the industry The role of integrated pest management and biological control of H hampei in an era of changes in the coffee industry is discussed

Gap junctions and cochlear homeostasis.

Abstract: Gap junctions play a critical role in hearing and mutations in connexin genes cause a high incidence of human deafness. Pathogenesis mainly occurs in the cochlea, where gap junctions form extensive networks between non-sensory cells that can be divided into two independent gap junction systems, the epithelial cell gap junction system and the connective tissue cell gap junction system. At least four different connexins have been reported to be present in the mammalian inner ear, and gap junctions are thought to provide a route for recycling potassium ions that pass through the sensory cells during the mechanosensory transduction process back to the endolymph. Here we review the cochlear gap junction networks and their hypothesized role in potassium ion recycling mechanism, pharmacological and physiological gating of cochlear connexins, animal models harboring connexin mutations and functional studies of mutant channels that cause human deafness. These studies elucidate gap junction functions in the cochlea and also provide insight for understanding the pathogenesis of this common hereditary deafness induced by connexin mutations.