Leibniz University of Hanover

About: Leibniz University of Hanover is a education organization based out in Hanover, Niedersachsen, Germany. It is known for research contribution in the topics: Finite element method & Population. The organization has 14283 authors who have published 29845 publications receiving 682152 citations.

Mechanosynthesis of Solid Electrolytes: Preparation, Characterization, and Li Ion Transport Properties of Garnet-Type Al-Doped Li7La3Zr2O12 Crystallizing with Cubic Symmetry

Abstract: Various polycrystalline samples of Al-doped garnet-like Li7La3Zr2O12 crystallizing with cubic symmetry were synthesized from the binary oxides Li2O, ZrO2, Al2O3, and La2O3. The synthesis of phase pure samples was carried out following a two-step preparation route. It consists of an activation step by high-energy ball milling and a subsequent annealing step at elevated temperatures. The synthesis route chosen allows the precise adjustment of the cationic ratios, leading to a garnet which is best described by the formula Li7–3x+zAlx+y+zLa3–yZr2–zO12. As confirmed by X-ray powder diffraction and 27Al magic angle spinning nuclear magnetic resonance (NMR), at low Al concentrations the incorporated Al3+ ions act as an aliovalent dopant by replacing three Li+ ions. However, with increasing Al content, La3+ and Zr4+ ions are progressively replaced by Al ions. It turned out that, in particular, the substitution of La3+ and Zr4+ with Al3+ ions stabilizes the cubic modification of the garnet and greatly affects the ...

Staphylococcus aureus alpha-toxin-induced cell death: predominant necrosis despite apoptotic caspase activation.

Abstract: Recent data suggest that alpha-toxin, the major hemolysin of Staphylococcus aureus, induces cell death via the classical apoptotic pathway. Here we demonstrate, however, that although zVAD-fmk or overexpression of Bcl-2 completely abrogated caspase activation and internucleosomal DNA fragmentation, they did not significantly affect alpha-toxin-induced death of Jurkat T or MCF-7 breast carcinoma cells. Caspase inhibition had also no effect on alpha-toxin-induced lactate dehydrogenase release and ATP depletion. Furthermore, whereas early assessment of apoptosis induction by CD95 resulted solely in the generation of cells positive for active caspases that were, however, not yet permeable for propidium iodide, a substantial proportion of alpha-toxin-treated cells were positive for both active caspases and PI. Finally, electron microscopy demonstrated that even in the presence of active caspases, alpha-toxin-treated cells displayed a necrotic morphology characterized by cell swelling and cytoplasmic vacuolation. Together, our data suggest that alpha-toxin-induced cell death proceeds even in the presence of activated caspases, at least partially, in a caspase-independent, necrotic-like manner.

Optomechanical sensing of spontaneous wave-function collapse

Abstract: Quantum experiments with nanomechanical oscillators are regarded as a test bed for hypothetical modifications of the Schrodinger equation, which predict a breakdown of the superposition principle and induce classical behavior at the macroscale. It is generally believed that the sensitivity to these unconventional effects grows with the mass of the mechanical quantum system. Here we show that the opposite is the case for optomechanical systems in the presence of generic noise sources, such as thermal and measurement noise. We determine conditions for distinguishing these decoherence processes from possible collapse-induced decoherence in continuous optomechanical force measurements.

Meta-Blocking: Taking Entity Resolutionto the Next Level

Abstract: Entity Resolution is an inherently quadratic task that typically scales to large data collections through blocking. In the context of highly heterogeneous information spaces, blocking methods rely on redundancy in order to ensure high effectiveness at the cost of lower efficiency (i.e., more comparisons). This effect is partially ameliorated by coarse-grained block processing techniques that discard entire blocks either a-priori or during the resolution process. In this paper, we introduce meta-blocking as a generic procedure that intervenes between the creation and the processing of blocks, transforming an initial set of blocks into a new one with substantially fewer comparisons and equally high effectiveness. In essence, meta-blocking aims at extracting the most similar pairs of entities by leveraging the information that is encapsulated in the block-to-entity relationships. To this end, it first builds an abstract graph representation of the original set of blocks, with the nodes corresponding to entity profiles and the edges connecting the co-occurring ones. During the creation of this structure all redundant comparisons are discarded, while the superfluous ones can be removed by pruning of the edges with the lowest weight. We analytically examine both procedures, proposing a multitude of edge weighting schemes, graph pruning algorithms as well as pruning criteria. Our approaches are schema-agnostic, thus accommodating any type of blocks. We evaluate their performance through a thorough experimental study over three large-scale, real-world data sets, with the outcomes verifying significant efficiency enhancements at a negligible cost in effectiveness.

On classical de Sitter vacua in string theory

Abstract: We review the prospect of obtaining tree-level de Sitter (dS) vacua and slow-roll inflation models in string compactifications. Restricting ourselves to the closed string sector and assuming the absence of NSNS-sources, we classify the minimal classical ingredients that evade the simplest no-go theorems against dS vacua and inflation. Spaces with negative integrated curvature together with certain combinations of low-dimensional orientifold planes and low-rank RR-fluxes emerge as the most promising setups of this analysis. We focus on two well-controlled classes that lead to an effective 4D, = 1 supergravity description: Type IIA theory on group or coset manifolds with SU(3)-structure and O6-planes, as well as type IIB compactifications on SU(2)-structure manifolds with O5- and O7-planes. While fully stabilized AdS vacua are generically possible, a number of problems encountered in the search for dS vacua are discussed.