Institution
Leibniz University of Hanover
Education•Hanover, Niedersachsen, Germany•
About: Leibniz University of Hanover is a education organization based out in Hanover, Niedersachsen, Germany. It is known for research contribution in the topics: Finite element method & Population. The organization has 14283 authors who have published 29845 publications receiving 682152 citations.
Topics: Finite element method, Population, Laser, Gravitational wave, Membrane
Papers published on a yearly basis
Papers
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TL;DR: It has been demonstrated that complex natural products like the alkaloids +/-)-oxomaritidine and (+/-)-epimaritidine can be prepared by a sequence of five and six consecutive polymer-assisted steps, respectively, and the potent analgesic compound (+/--epibatidine in twelve linear steps ten of which are based on functionalized polymers.
Abstract: As part of the dramatic changes associated with the need for preparing compound libraries in pharmaceutical and agrochemical research laboratories, industry searches for new technologies that allow for the automation of synthetic processes. Since the pioneering work by Merrifield polymeric supports have been identified to play a key role in this field however, polymer-assisted solution-phase synthesis which utilizes immobilized reagents and catalysts has only recently begun to flourish. Polymer-assisted solution-phase synthesis has various advantages over conventional solution-phase chemistry, such as the ease of separation of the supported species from a reaction mixture by filtration and washing, the opportunity to use an excess of the reagent to force the reaction to completion without causing workup problems, and the adaptability to continuous-flow processes. Various strategies for employing functionalized polymers stoichiometrically have been developed. Apart from reagents that are covalently or ionically attached to the polymeric backbone and which are released into solution in the presence of a suitable substrate, scavenger reagents play an increasingly important role in purifying reaction mixtures. Employing functionalized polymers in solution-phase synthesis has been shown to be extremely useful in automated parallel synthesis and multistep sequences. So far, compound libraries containing as many as 88 members have been generated by using several polymer-bound reagents one after another. Furthermore, it has been demonstrated that complex natural products like the alkaloids (+/-)-oxomaritidine and (+/-)-epimaritidine can be prepared by a sequence of five and six consecutive polymer-assisted steps, respectively, and the potent analgesic compound (+/-)-epibatidine in twelve linear steps ten of which are based on functionalized polymers. These developments reveal the great future prospects of polymer-assisted solution-phase synthesis.
346 citations
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TL;DR: A comprehensive solution for automatically detecting, identifying, and segmenting vertebrae in CT images by designing a framework that takes an arbitrary CT image as input and provides a segmentation in form of labelled triangulated vertebra surface models.
346 citations
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TL;DR: The Schmidt number of a bipartite density matrix was introduced in this article, where the Schmidt number is defined as the family of states that is made from mixing the completely mixed state and a maximally entangled state.
Abstract: We introduce the notion of a Schmidt number of a bipartite density matrix. We show that k-positive maps witness the Schmidt number, in the same way that positive maps witness entanglement. We determine the Schmidt number of the family of states that is made from mixing the completely mixed state and a maximally entangled state. We show that the Schmidt number does not necessarily increase when taking tensor copies of a density matrix $\ensuremath{\rho};$ we give an example of a density matrix for which the Schmidt numbers of $\ensuremath{\rho}$ and $\ensuremath{\rho}\ensuremath{\bigotimes}\ensuremath{\rho}$ are both $2.$
342 citations
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TL;DR: In this paper, the results of deep drawing tests with magnesium alloys AZ31B, AZ61B, and M1 showed very good formability in a temperature range between 200 and 250°C, and the influence of forming speed on limit drawing ratio has been investigated.
341 citations
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TL;DR: Thrombolytic therapy has led to a higher proportion of patients presenting to hospital early, and this, with parallel developments in imaging technology, has greatly improved the understanding of acute stroke pathophysiology.
Abstract: Summary Thrombolytic therapy has led to a higher proportion of patients presenting to hospital early, and this, with parallel developments in imaging technology, has greatly improved the understanding of acute stroke pathophysiology. Additionally, MRI, including diffusion-weighted imaging (DWI) and gradient echo, or T2*, imaging is important in understanding basic structural information—such as distinguishing acute ischaemia from haemorrhage. It has also greatly increased sensitivity in the diagnosis of acute cerebral ischaemia. The pathophysiology of the ischaemic penumbra can now be assessed with CT or MRI-based perfusion imaging techniques, which are widely available and clinically applicable. Pathophysiological information from CT or MRI increasingly helps clinical trial design, may allow targeted therapy in individual patients, and may extend the time scale for reperfusion therapy.
340 citations
Authors
Showing all 14621 results
Name | H-index | Papers | Citations |
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Hyun-Chul Kim | 176 | 4076 | 183227 |
Peter Zoller | 134 | 734 | 76093 |
J. R. Smith | 134 | 1335 | 107641 |
Chao Zhang | 127 | 3119 | 84711 |
Benjamin William Allen | 124 | 807 | 87750 |
J. F. J. van den Brand | 123 | 777 | 93070 |
J. H. Hough | 117 | 904 | 89697 |
Hans-Peter Seidel | 112 | 1213 | 51080 |
Karsten Danzmann | 112 | 754 | 80032 |
Bruce D. Hammock | 111 | 1409 | 57401 |
Benno Willke | 109 | 508 | 74673 |
Roman Schnabel | 108 | 589 | 71938 |
Jan Harms | 108 | 447 | 76132 |
Hartmut Grote | 108 | 434 | 72781 |
Ik Siong Heng | 107 | 423 | 71830 |