Showing papers by "Leicester Royal Infirmary published in 1979"

Timolol in Migraine Prophylaxis

Abstract: SYNOPSIS The literature on the use of beta-blocking drugs in migraine suggests that not all such agents are effective. A double-blind crossover study of timolol in migraine prophylaxis was undertaken with fourteen patients, in order to assess the value of this drug in particular, and also to elucidate further the reason for the varied response to different beta-blockers. Timolol significantly reduced the frequency of migraine attacks, and was preferred to placebo. This supports the contention that beta-blocking drugs without intrinsic sympathomimetic activity are effective in migraine prophylaxis.

Transposition of radius and ulna associated with dislocation of the elbow in a child.

Abstract: A case of transposition of the radius and ulna associated with posterior dislocation of the elbow in a child is reported.

Bone lesions in systemic acne (acne fulminans).

Abstract: SUMMARY An 18-year-old West Indian male presented with severe sternal pain and an exacerbation of facial acne. Radiographs of the sternum revealed several lytic lesions which appeared as hot areas on succes-sive technetium bone scans. Painful areas over the right iliac crest and left greater trochanter likewise appeared as transient hot areas on successive scans. Histology of affected bone revealed reactive changes only. High dose prednisolone provided rapid alleviation of pain, which recurred on reducing the dose to less than 10 mg daily. Auto-immune complex disease has been considered the most likely aetiological mechanism of systemic acne (acne fulminans), but lytic lesions of bone have never previously been reported in auto-immune disorders.

The influence of gestational age and size on the absorption of D-xylose and D-glucose from the small intestine of the human neonate.

Abstract: D-Xylose absorption (using the one-hour blood levels) and active D-glucose absorption (calculated from changes in transmural electrical potential difference) have been measured after intraduodenal infusion of the appropriate sugar, in groups of neonates who were full-term or preterm, and who were in addition either appropriately sized for gestational age, or growth-retarded in utero. The one-hour D-xylose blood levels were significantly lower in preterm infants, and were even lower in the growth-retarded group. In follow-up studies D-xylose absorption rose in all groups of infants over the first three weeks of postnatal life but there was no sign of 'catch-up' in the results of the growth-retarded infants. In the studies of D-glucose absorption the theoretical kinetic parameters 'apparent P.D.max' (equivalent to Vmax) and 'apparent Km' were calculated. Normal full-term infants had values for both parameters that were approximately two-thirds of published adult values. Malnourished neonates had significantly lower P.D.max and apparent Km, and preterm infants had a lower P.D.max, than the values obtained in those infants who were full-term and appropriately grown.

Effects of rest, exercise and warming on serum creatine kinase levels in primary hypothyroidism.

Abstract: 1. Serum creatine kinase and oral temperature were measured in 20 patients with primary hypothyroidism before and after 48 h bed rest. Fifteen of these patients were heated during the 48 h period. The remaining five acted as control subjects. In addition, creatine kinase and oral temperature were measured in five control subjects after a 30 min period of exercise and again after a 30 min period of resting. 2. The oral temperature rose and the serum creatine kinase levels fell only in those patients who were actively warmed. In the control subjects the period of exercise followed by resting caused no significant change in creatine kinase levels. 3. A subnormal body temperature appears to be an important determinant of the raised serum creatine kinase levels seen in patients with primary hypothyroidism.