Leicester Royal Infirmary

About: Leicester Royal Infirmary is a healthcare organization based out in Leicester, United Kingdom. It is known for research contribution in the topics: Population & Carotid endarterectomy. The organization has 5300 authors who have published 6204 publications receiving 208464 citations.

Comparison of effects of remifentanil and alfentanil on cardiovascular response to tracheal intubation in hypertensive patients

Abstract: In a randomized double-blind study, we compared the effect of remifentanil and alfentanil on the cardiovascular response to laryngoscopy and tracheal intubation in patients on long-term treatment for hypertension. Forty ASA II–III patients were allocated to receive (i) remifentanil 0.5 μg kg−1 followed by an infusion of 0.1 μg kg min−1 or (ii) alfentanil 10 μg kg−1 followed by an infusion of saline; all patients received glycopyrrolate 200 μg before the study drug. Anaesthesia was induced with propofol and rocuronium and maintained with 1% isoflurane and 66% nitrous oxide in oxygen. Laryngoscopy and tracheal intubation were performed after establishment of neuromuscular block. Arterial pressure and heart rate (HR) were measured non-invasively at 1 min intervals from 3 min before induction until 5 min after intubation. Systolic (SAP), diastolic and mean arterial pressure decreased significantly after induction in both groups (P

Rapid‐bolus contrast‐enhanced dynamic computed tomography in acute pancreatitis: A prospective study

Abstract: The purpose of this prospective study was to determine the clinicopathological significance of necrotic areas demonstrated by rapid-bolus contrast-enhanced computed tomography (CT) in patients with biochemically predicted severe pancreatitis. Although CT necrosis occurred significantly more frequently in patients with clinically severe (ten of 12) compared with mild (seven of 20) pancreatitis (P less than 0.025), seven of 17 (41 per cent) patients with CT necrosis developed clinically mild pancreatitis and six of ten (60 per cent) patients with clinically severe pancreatitis and CT necrosis recovered with conservative management. The site and extent of CT necrosis did not correlate with disease severity. Fine-needle aspiration cytology, operative and post-mortem findings and endoscopic retrograde cholangiopancreatography examinations all strongly suggested that CT necrosis represents true pancreatic necrosis. We conclude that the finding of CT necrosis is not in itself an indication for operative intervention, but that rapid-bolus contrast-enhanced dynamic CT greatly facilitates the planning and execution of surgical therapy.

Clinical Practice Guideline on management of older patients with chronic kidney disease stage 3b or higher (eGFR<45 mL/min/1.73 m2): a summary document from the European Renal Best Practice Group.

Abstract: The population of patients with moderate and severe CKD is growing. Frail and older patients comprise an increasing proportion. Many studies still exclude this group, so the evidence base is limited. In 2013 the advisory board of ERBP initiated, in collaboration with European Union of Geriatric Medicine Societies (EUGMS), the development of a guideline on the management of older patients with CKD stage 3b or higher (eGFR >45 mL/min/1.73 m2). The full guideline has recently been published and is freely available online and on the website of ERBP (www.european-renal-best-practice.org). This paper summarises main recommendations of the guideline and their underlying rationales.

Screening for abnormal eating attitudes in a population of Egyptian secondary school girls.

Abstract: Recent research indicates that identification with the western ideal of slimness can be followed by heightened weight consciousness and development of eating disorders in cultures thought to be relatively immune from developing such disorders. In this study, which is based on an earlier one by the same author, a popalation of secondary school girls in Cairo, Egypt (n=351) was screened for abnormal eating attitudes using a translated version of the Eating Attitude Test Questionnaire. Of the girls screened, 11.4% scored positively on the questionnaire and were subsequently interviewed. Three cases clearly fulfilled Russell's criteria for a diagnosis of the full syndrome of bulimia nervosa (1.2%). This is broadly in keeping with rates in studies in the United Kingdom. Twelve pupils (3.4%) showed sufficient concern over their weight to qualify for diagnosis as a partial syndrome of bulimia nervosa. The results confirmed the initial impression that disorders of eating are emerging in cultures that did not produce such morbidity in the past, with more or less the same prevalence as in the United Kingdom. The study concludes that no society is truly immune to the development of such disorders, because of the globalisation of culture by virtue of the media.