Institution
Leicester Royal Infirmary
Healthcare•Leicester, United Kingdom•
About: Leicester Royal Infirmary is a healthcare organization based out in Leicester, United Kingdom. It is known for research contribution in the topics: Population & Carotid endarterectomy. The organization has 5300 authors who have published 6204 publications receiving 208464 citations.
Papers published on a yearly basis
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University of Luxembourg1, Hannover Medical School2, Leicester Royal Infirmary3, Örebro University4, Royal Children's Hospital5, University of the Basque Country6, Children's Hospital Los Angeles7, Trinity College, Dublin8, Peijas Hospital9, University of Tübingen10, University of Bergen11, Haukeland University Hospital12, Boston Children's Hospital13, Necker-Enfants Malades Hospital14, Nihon University15, University of Birmingham16, University of Copenhagen Faculty of Health Sciences17, Herlev Hospital18
TL;DR: In this article, the authors investigated whether center differences in glycemic control are present in prepubertal children and found that center differences were present in metabolic outcomes, including severe hypoglycemia, but not DKA.
Abstract: Objective: To investigate whether center differences in glycemic control are present in prepubertal children Research Design and Methods: This cross-sectional study involved 18 pediatric centers worldwide. All children, Results: A total of 1133 children participated (mean age: 8.0 +/- 2.1 y; females: 47.5%, mean diabetes duration: 3.8 +/- 2.1 y). HbA1c (overall mean: 8.0 +/- 1.0%; range: 7.3-8.9%) and severe hypoglycemia frequency (mean 21.7 events per 100 patient-years), but not DKA, differed significantly between centers (p Conclusions: Center differences in metabolic outcomes are present in children
62 citations
TL;DR: It is concluded that, while GOR and obstructive episodes may co-exist in the patient groups studied, decreases in pH in the lower oesophagus do not usually induce either central or obstructive apnoea, and vice versa.
Abstract: We studied the relation of gastro-oesophageal reflux with apnoea during sleep in 24 infants with antecedent respiratory abnormalities and/or proven gastro-oesophageal reflux (GOR), by combined lower oesophageal pH and polygraphic monitoring. GOR, indicated by pH 20s) central apnoea (CA). Fifty-six mixed or obstructive breathing episodes were identified in 12 infants (14 studies), of which 28 lasted between 3 and 6s. Bradycardia (heart rate less than 5 mmHg) but only 6 exceeded 10 mmHg and one 20 mmHg. There was no relationship between GOR and obstructive episodes in terms of frequency, duration or temporal occurrence, except in one infant. There were 1276 gross body movements, mainly during active or indeterminate sleep and, of these, 7% were associated with decreases in pH to 1 pH unit compared to only 30% in the 60s succeeding a pH drop. We conclude that, while GOR and obstructive episodes may co-exist in the patient groups studied, decreases in pH in the lower oesophagus do not usually induce either central or obstructive apnoea, and vice versa. Of the variables monitored, only gross body movements were temporally associated with pH drops, and usually preceded them.
62 citations
TL;DR: In middle-aged and older people, sustained untreated hypertension does not alter dynamic CA or the efficiency of static CA within the BP limits studied.
62 citations
Haukeland University Hospital1, Great Ormond Street Hospital2, University of Bergen3, University of Erlangen-Nuremberg4, Leicester Royal Infirmary5, Charles University in Prague6, Queen's University7, Medical University of Silesia8, Boston Children's Hospital9, Heidelberg University10, Utrecht University11, St George's, University of London12, Tripler Army Medical Center13, University of Rostock14, Cincinnati Children's Hospital Medical Center15, University of Gdańsk16
TL;DR: In this paper, a multicenter study of 17 patients with molecularly confirmed Pierson syndrome was conducted, where the most characteristic ocular anomaly was microcoria and a wide range of additional abnormalities were found, including posterior embryotoxon, megalocornea, iris hypoplasia, cataract, abnormal lens shape, posterior lenticonus, persistent fetal vasculature, retinal detachment, variable axial lengths, and glaucoma.
62 citations
TL;DR: Recommendable HbA1c cut-points to detect IGR significantly increase numbers detected, however introduce a change in people identified, which lacks sensitivity in white Europeans, but is a reasonable option in south Asians.
62 citations
Authors
Showing all 5314 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| George Davey Smith | 224 | 2540 | 248373 |
| Nilesh J. Samani | 149 | 779 | 113545 |
| Peter M. Rothwell | 134 | 779 | 67382 |
| John F. Thompson | 132 | 1420 | 95894 |
| James A. Russell | 124 | 1024 | 87929 |
| Paul Bebbington | 119 | 583 | 46341 |
| John P. Neoptolemos | 112 | 648 | 52928 |
| Richard C. Trembath | 107 | 368 | 41128 |
| Andrew J. Wardlaw | 92 | 311 | 33721 |
| Melanie J. Davies | 89 | 814 | 36939 |
| Philip Quirke | 89 | 378 | 34071 |
| Kenneth J. O'Byrne | 87 | 629 | 39193 |
| David R. Jones | 87 | 707 | 40501 |
| Keith R. Abrams | 86 | 355 | 30980 |
| Martin J. S. Dyer | 85 | 373 | 24909 |