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Institution

Leicester Royal Infirmary

HealthcareLeicester, United Kingdom
About: Leicester Royal Infirmary is a healthcare organization based out in Leicester, United Kingdom. It is known for research contribution in the topics: Population & Carotid endarterectomy. The organization has 5300 authors who have published 6204 publications receiving 208464 citations.


Papers
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Journal ArticleDOI
TL;DR: In the European Carotid Surgery Trial (ECST) as mentioned in this paper, ancillary surgical techniques, such as shunting and patching, are used in association with carotid endarterectomy.

60 citations

Journal ArticleDOI
TL;DR: UII levels are raised in AMI and is an independent predictor of ACO, suggesting a possible cardioprotective role for this peptide in patients with a poor outcome.

60 citations

Journal ArticleDOI
TL;DR: In view of the frequent occurrence of this sign in antisynthetase syndrome, and the importance of early management, careful examination of the hands is mandatory in patients with systemic signs such as interstitial lung disease, myositis and arthritis.
Abstract: hands of manual workers. Discrimination between occupational dermatitis and MH is difficult; however, lesions appear well demarcated with interface dermatitis in the latter. Therefore, the diagnosis of MH should be considered in patients especially when they present with general signs, interstitial lung disease and/or inflammatory muscle disease and/or polyarthritis requiring a search for anti-Jo-1 antibodies. A close association has been shown between MH and anti-Jo-1 antibodies, but MH has also been reported in polymyositis, dermatomyositis, childhood sclerodermatomyositis and mixed connective disease. In two of seven patients, MH occurred in the course of known idiopathic inflammatory myopathy in whom the skin was not involved initially. In these cases, systemic involvement developed concomitantly or soon after. A skin flare was therefore always associated with deep tissue flare; such an event in patients with antisynthetase syndrome implies deep organ assessment. The patients with MH became clear of their lesions together with clearance of the deep tissue disease. When MH was associated with idiopathic inflammatory myopathy in our series, it never appeared as an isolated skin sign. This suggests that when MH is present in a patient free of systemic signs, the diagnosis cannot be antisynthetase syndrome; the hand lesions belong rather to a classical occupational dermatitis and a search for anti-Jo-1 antibodies need not be done in this situation. Prognosis of the antisynthetase syndrome is poor as its mortality rate is 40%, with 62% in patients with interstitial lung disease, but could be improved by an early diagnosis. Therefore, in view of the frequent occurrence of this sign in antisynthetase syndrome, and the importance of early management, careful examination of the hands is mandatory in patients with systemic signs such as interstitial lung disease, myositis and arthritis.

60 citations

Journal ArticleDOI
TL;DR: Reductions in baroreflex sensitivity with hypertension in elderly subjects consistent across all methods but with no difference between subjects with combined hypertension and isolated systolic hypertension matched for similar syStolic pressure are demonstrated.
Abstract: Uncertainty still remains regarding the differing effects of blood pressure and age on baroreceptor-cardiac reflex sensitivity in elderly individuals; these differences are at least partly due to the differing methods and subject groups used in previous studies. We sought to resolve these issues by examining baroreflex sensitivity in 54 subjects aged 70 +/- 1 years (mean +/- SE; range, 60 to 81) divided into groups with combined systolic-diastolic hypertension (CH group, n = 16), isolated systolic hypertension (ISH group, n = 16), or normotension (NT group, n = 22). Baroreflex sensitivity was quantified from the pulse interval and blood pressure responses to the Valsalva maneuver and pressor (phenylephrine) and depressor (sodium nitroprusside) stimuli. Baroreflex sensitivity was significantly reduced in the two hypertensive groups but did not differ between them (Valsalva maneuver: CH group, 1.9 +/- 0.3 ms/mm Hg; ISH group, 2.8 +/- 0.5; NT group, 4.4 +/- 0.4; phenylephrine: CH group, 3.1 +/- 0.6; ISH group, 3.5 +/- 0.7; NT group, 7.7 +/- 1.0; sodium nitroprusside CH group, 2.1 +/- 0.3; ISH group, 3.6 +/- 0.8; NT group, 5.4 +/- 0.3; all P < .05 for comparison with the NT group). Thus, this study demonstrated reductions in baroreflex sensitivity with hypertension in elderly subjects consistent across all methods but with no difference between subjects with combined hypertension and isolated systolic hypertension matched for similar systolic pressure. Baroreflex sensitivity was related only to the level of systolic pressure independent of diastolic pressure or age. If elderly subjects with isolated systolic hypertension have a greater reduction in large-artery compliance than combined hypertensive subjects with similar systolic pressure, this does not appear to lead to further reductions in baroreflex sensitivity in these individuals.

60 citations

Journal ArticleDOI
08 May 1995
TL;DR: Investigation of the abilities of the antibodies to bind to theα2 and δ subunits in intact and detergent‐permeabilised rat dorsal root ganglion cells enabled the membrane orientation of these regions to be established, findings consistent with a model that proposesα2 to be entirely extracellular.
Abstract: Polyclonal antibodies were raised against peptides corresponding to residues 1–15, 469–483 and 933–951 of the rabbit skeletal muscle L-type calcium channelα2/δ primary translation product, for use as topological probes. Immunocytochemical comparison of the abilities of the antibodies to bind to theα2 and δ subunits in intact and detergent-permeabilised rat dorsal root ganglion cells enabled the membrane orientation of these regions to be established. The resultant data indicate that the regions containing residues 1–15 and 469–483 of theα2 subunit, and residues 1–17 of the δ subunit, are exposed on the extracellular surface of the membrane, findings consistent with a model that proposesα2 to be entirely extracellular.

60 citations


Authors

Showing all 5314 results

NameH-indexPapersCitations
George Davey Smith2242540248373
Nilesh J. Samani149779113545
Peter M. Rothwell13477967382
John F. Thompson132142095894
James A. Russell124102487929
Paul Bebbington11958346341
John P. Neoptolemos11264852928
Richard C. Trembath10736841128
Andrew J. Wardlaw9231133721
Melanie J. Davies8981436939
Philip Quirke8937834071
Kenneth J. O'Byrne8762939193
David R. Jones8770740501
Keith R. Abrams8635530980
Martin J. S. Dyer8537324909
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20234
202219
2021168
2020120
2019110
2018121