Leicester Royal Infirmary

About: Leicester Royal Infirmary is a healthcare organization based out in Leicester, United Kingdom. It is known for research contribution in the topics: Population & Carotid endarterectomy. The organization has 5300 authors who have published 6204 publications receiving 208464 citations.

Cardiac resynchronisation therapy for the treatment of heart failure: NICE technology appraisal guidance

Abstract: This NICE technology appraisal guidance on cardiac resynchronisation therapy provides additional treatment options for some of the groups of people covered in the earlier guidance on implantable cardioverter defibrillators.

Seven year follow-up of age-related maculopathy in an elderly British population.

Abstract: SUMMARY Despite age-related macular degeneration (AMD) being the commonest cause of blindness amongst the elderly in Western society, the incidence of new lesions is poorly docnmented and the natural history of existing disease remains ill understood. Purpose: To document in an elderly population the incidence of new AMD lesions and the progression of pre-existing AMD over time. Method: Baseline ophthalmic examinations were per­ formed on a geographically defined random population sample of elderly people in 1982-4, and retinal photographs taken. The present study re-examined md re-photographed survivors after approximately 7 years using the same fundus camera. Photographs were randomly encoded, and independently graded for AMD features by two masked observers using the Wisconsin AMD grading system. Disagreements were resolved by review to reach a consensus. Results: Eighty-two of the 88 participating survivors had photographs of gradable quality on both occasions in at least one eye. Mean age at foJ)ow-up was 87 years (range 84-97 years) and 70.7% of subjects were female. Paired photographs were available on 158 eyes, and showed important differences in drusen type, drusen area and characteristics of the retinal pigment epithe­ lium (RPE) between initial and subsequent examina­ ions. The 7 year incidence (and regression) of lesions was: drusen 30.6% (20.0%), RPE degeneration 54.5% (8.8%), increased pigment 11.6% (64.7%), subretinal ltaemorrhage 1.3%, subretinal scar/fibrin 1.3% and coograpbic study 1.3%.

Prioritizing research: Patients, carers, and clinicians working together to identify and prioritize important clinical uncertainties in urinary incontinence.

Abstract: Aims Research often neglects important gaps in existing evidence. Throughout healthcare, clinicians and patients face avoidable “clinical uncertainties” daily, making decisions about treatments without reliable evidence about their effects. This partnership of patients and clinicians aimed to identify and prioritize “clinical uncertainties” relating to treatment of urinary incontinence (UI). Methods UK clinician and patient organizations whose remit includes UI were invited to participate. Participating organizations consulted memberships to identify “uncertainties” affecting treatment decisions. “Uncertainties” were also identified in published research recommendations. Prioritization involved two phases: shortlisting of “uncertainties” by organizations; patient-clinician prioritization using established consensus methods. Prioritized “uncertainties” were verified by checking any available relevant up-to-date published systematic reviews. Results Thirty organizations were invited; 8 patient and 13 clinician organizations participated. Consultation generated 417 perceived “uncertainties,” research recommendations 131. Refining, excluding and combining produced a list of 226. Prioritization shortlisted 29 “uncertainties,” then a “top ten” (5 submitted by clinicians, 4 by patients, 1 from research recommendations). Conclusions The partnership successfully developed and tested a systematic and transparent methodology for patient–clinician consultation and consensus. Through consensus, unanswered research questions of importance to patients and clinicians were identified and prioritized. The final list reflects the heterogeneity of populations, treatments and evidence needs associated with UI. Some prioritized “uncertainties” relate to treatments that are widely used yet whose effects are not thoroughly understood, some to access to care, some to precise surgical questions. Research needs to address the uncertainties range from systematic reviewing to primary research. Neurourol. Urodynam. 29:708–714, 2010. © 2010 Wiley-Liss, Inc.

Driving with Glaucoma: Task Performance and Gaze Movements.

Abstract: PurposeThe aim of this pilot study was to assess the driving performance and the visual search behavior, that is, eye and head movements, of patients with glaucoma in comparison to healthy-sighted subjects during a simulated driving test.MethodsDriving performance and gaze behavior of six gl