Institution
Life Sciences Institute
About: Life Sciences Institute is a based out in . It is known for research contribution in the topics: Population & Autophagy. The organization has 4183 authors who have published 3749 publications receiving 132087 citations.
Topics: Population, Autophagy, Gene, Signal transduction, Cancer
Papers published on a yearly basis
Papers
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TL;DR: The epidemic of type 2 diabetes and impaired glucose tolerance is one of the main causes of morbidity and mortality worldwide, and tissues such as muscle, fat and liver become less responsive or resistant to insulin.
Abstract: The epidemic of type 2 diabetes and impaired glucose tolerance is one of the main causes of morbidity and mortality worldwide. In both disorders, tissues such as muscle, fat and liver become less responsive or resistant to insulin. This state is also linked to other common health problems, such as obesity, polycystic ovarian disease, hyperlipidaemia, hypertension and atherosclerosis. The pathophysiology of insulin resistance involves a complex network of signalling pathways, activated by the insulin receptor, which regulates intermediary metabolism and its organization in cells. But recent studies have shown that numerous other hormones and signalling events attenuate insulin action, and are important in type 2 diabetes.
4,935 citations
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TL;DR: Identifying the autophagy genes in yeast and finding orthologs in other organisms reveals the conservation of the mechanism in eukaryotes and allows the use of molecular genetics and biology in different model systems to study this process.
Abstract: Autophagy, the process by which cells recycle cytoplasm and dispose of excess or defective organelles, has entered the research spotlight largely owing to the discovery of the protein components that drive this process. Identifying the autophagy genes in yeast and finding orthologs in other organisms reveals the conservation of the mechanism of autophagy in eukaryotes and allows the use of molecular genetics and biology in different model systems to study this process. By mostly morphological studies, autophagy has been linked to disease processes. Whether autophagy protects from or causes disease is unclear. Here, we summarize current knowledge about the role of autophagy in disease and health.
2,451 citations
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TL;DR: This review traces the key findings that led to the current molecular understanding of this complex process, which is involved in physiology, development, lifespan and a wide range of diseases, including cancer, neurodegeneration and microbial infection.
Abstract: Macroautophagy (hereafter autophagy), or 'self-eating', is a conserved cellular pathway that controls protein and organelle degradation, and has essential roles in survival, development and homeostasis. Autophagy is also integral to human health and is involved in physiology, development, lifespan and a wide range of diseases, including cancer, neurodegeneration and microbial infection. Although research on this topic began in the late 1950s, substantial progress in the molecular study of autophagy has taken place during only the past 15 years. This review traces the key findings that led to our current molecular understanding of this complex process.
1,901 citations
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TL;DR: In 2000, it was suggested to me that “Autophagy will be the wave of the future; it will become the new apoptosis,” and this statement turned out to be prophetic, and this process of 'self-eating' rapidly exploded as a research field, as scientists discovered connections to cancer, neurodegeneration and even lifespan extension.
Abstract: In 2000, it was suggested to me that "Autophagy will be the wave of the future; it will become the new apoptosis." Few people would have agreed at the time, but this statement turned out to be prophetic, and this process of 'self-eating' rapidly exploded as a research field, as scientists discovered connections to cancer, neurodegeneration and even lifespan extension. Amazingly, the molecular breakthroughs in autophagy have taken place during only the past decade.
1,827 citations
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TL;DR: The Hippo pathway regulates cell proliferation, apoptosis, and stemness in response to a wide range of extracellular and intracellular signals, including cell-cell contact, cell polarity, mechanical cues, ligands of G-protein-coupled receptors, and cellular energy status.
1,571 citations
Authors
Showing all 4183 results
Name | H-index | Papers | Citations |
---|---|---|---|
Feng Zhang | 172 | 1278 | 181865 |
Kevin Murphy | 146 | 728 | 120475 |
Kun-Liang Guan | 143 | 427 | 94520 |
Paolo Vineis | 134 | 1088 | 86608 |
Daniel J. Klionsky | 131 | 565 | 90977 |
Jacques S. Beckmann | 117 | 441 | 63543 |
Iain B. McInnes | 111 | 655 | 59238 |
Hong Wang | 110 | 1633 | 51811 |
Ivan Dikic | 107 | 359 | 52088 |
Fei Wang | 107 | 1824 | 53587 |
Yigong Shi | 106 | 248 | 48257 |
Kazuaki Chayama | 105 | 1511 | 52413 |
Jos W. R. Twisk | 105 | 782 | 43897 |
Charles L. Brooks | 102 | 441 | 46844 |
Peter ten Dijke | 101 | 286 | 40776 |