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Institution

Lincoln Hospital

HealthcareNew York, New York, United States
About: Lincoln Hospital is a healthcare organization based out in New York, New York, United States. It is known for research contribution in the topics: Population & Emergency department. The organization has 1033 authors who have published 929 publications receiving 14486 citations. The organization is also known as: Lincoln Medical and Mental Health Center & Lincoln Hospital.


Papers
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Journal ArticleDOI
Anna Rutgersson1
TL;DR: Uppal et al. as mentioned in this paper compared the incidence of BSI, clinical and microbial characteristics of infection among patients with BSI before and during the surge of the COVID-19 pandemic.

4 citations

Journal ArticleDOI
TL;DR: The purpose of this narrative review is to address the advantages and shortcomings with clinical use of fixed-dose 4F-PCC, as well as limitations of the available literature, and to guide future studies to support or refute this potentially life-saving intervention.
Abstract: 4-Factor Prothrombin Complex Concentrate (4F-PCC) is the standard-of-care intervention in patients with major bleeding taking oral vitamin K antagonists. Despite growing clinical experience with 4-FPCC, the optimal dosing strategy remains unclear. In balancing efficacy, safety, and cost of this treatment, many institutions have adopted a low, fixed-dose regimen, with average doses lower than that in the package insert. The fixed-dose 4F-PCC strategy is supported by the available observational studies and case reports; however, the current body of literature is highly heterogenous. The purpose of this narrative review is to address the advantages and shortcomings with clinical use of fixed-dose 4F-PCC, as well as limitations of the available literature. The heterogeneity of the current literature should guide future studies to support or refute this potentially life-saving intervention.

4 citations

Posted ContentDOI
04 Jun 2021-medRxiv
TL;DR: Zhang et al. as mentioned in this paper analyzed a large cohort of individuals with GABRB3 variants to deepen the phenotypic understanding and investigate genotype-phenotype correlations, finding that phenotypes correlated with structural locations of the variants.
Abstract: Objective: Pathogenic variants in GABRB3 have been associated with a spectrum of phenotypes from severe developmental disorders and epileptic encephalopathies to milder epilepsy syndromes and mild intellectual disability. In the present study, we analyzed a large cohort of individuals with GABRB3 variants to deepen the phenotypic understanding and investigate genotype-phenotype correlations. Methods: Through an international collaboration, we analyzed electro-clinical data of unpublished individuals with variants in GABRB3 and we reviewed previously published cases. All missense variants were mapped onto the 3D structure of the GABRB3 subunit and clinical phenotypes associated with the different key structural domains were investigated. Results: We characterize 71 individuals with GABRB3 variants, including 22 novel subjects, expressing a wide spectrum of phenotypes. Interestingly, phenotypes correlated with structural locations of the variants. Generalized epilepsy, with a median age at onset of 10.5 months, and mild-to-moderate intellectual disability were associated with variants in the extracellular domain. Focal epilepsy with early onset (median: 2.75 months of age) and severe intellectual disability were associated with variants in the pore-lining helical transmembrane domain. Significance: These genotype/phenotype correlations will aid the genetic counseling and treatment of individuals affected by GABRB3-related disorders. Future studies may reveal whether functional differences underlie the phenotypic differences.

4 citations

Journal ArticleDOI
TL;DR: Older women with prolapse should be evaluated with emphasis on functional status and individualized assessment of risks, benefits, and alternatives of therapies, as in other areas of geriatric medicine.
Abstract: Purpose of Review Pelvic organ prolapse (POP) is a common condition that can adversely affect quality of life in older women. With the current trend in longevity, the number of women with this problem will exceed the availability of subspecialists in Female Pelvic Medicine and Reconstructive Surgery. The purpose of this paper is to aid primary care physicians, geriatricians, and general gynecologists in the evaluation, referral, and treatment of women with POP. Women can be quickly evaluated and offered therapy prior to referral to a subspecialist.

4 citations

Journal ArticleDOI
TL;DR: The fact that mass lesions in the temporal lobe, including high-grade astrocytoma, should be considered in the differential diagnosis of suspected herpes simplex encephalitis, especially those not responding to therapy is emphasized.

4 citations


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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20231
20224
202178
202086
201984
201839