Lincoln Hospital

About: Lincoln Hospital is a healthcare organization based out in New York, New York, United States. It is known for research contribution in the topics: Population & Emergency department. The organization has 1033 authors who have published 929 publications receiving 14486 citations. The organization is also known as: Lincoln Medical and Mental Health Center & Lincoln Hospital.

Husband/Partner Intoxication and Intimate Partner Violence Against Women in the Philippines

Abstract: This study examined husband/partner intoxication and experience with physical, sexual, and emotional intimate partner violence against women (IPVAW) using data derived from a nationally representative survey conducted in the Philippines in 2013. Multivariate logistic regression analyses were used to examine the association between intoxication and 3 different types of intimate partner violence against women. Multinomial logistic regression was used to examine intoxication and severity of violence. In this sample, 28.8% of women reported experiencing any form of intimate partner violence and 92.9% of women reported their partner being intoxicated at least sometimes. Intoxication was significantly associated with all 3 types of intimate partner violence, while the odds of experiencing one form of IPVAW versus no form of IPVAW and 2 forms of IPVAW versus 1 form of IPVAW was greater among women reporting frequency of husband/partner intoxication as often.

SAT0211 14-3-3 ETA Protein: A Novel Biomarker for the Diagnosis of Rheumatoid Arthritis

Abstract: Background Serum 14-3-3 eta has been described to have diagnostic utility and in established RA an association has been established between the levels of this marker and the degree of joint damage. The η isoform of 14-3-3 is expressed extracellularly in much higher concentration than the Υ isoform or MMP 1 and 3 levels in the synovial fluid and serum of patients with rheumatoid arthritis compared to the normal population. Rheumatoid factor (RF) is known to be sensitive and anti CCP highly specific for RA, but a high number of patients remain seronegative. There is a need for a biomarker to prevent underdiagnosis in this subset. Objectives The purpose of the study was to investigate if serum 14-3-3 η enhanced the detection of RA over RF or anti CCP in RA patients. We also studied the utility of 14-3-3 eta as a diagnostic test by comparing presence of this protein in RA v/s non-RA patients. Methods A retrospective chart review study was conducted in RA patients at an outpatient rheumatology clinic in an inner city population at a community teaching hospital serving a large immigrant population. 91 RA patients were identified who satisfied the 2010 ACR diagnostic criteria and 37 non RA patients seen in the clinic for other rheumatologic conditions were chosen as the control group. Serum 14-3-3η protein was measured by ELISA. The positive threshold range using Quest Diagnostic for RF was 15 International Unit/ml, Anti CCP was 20 Units and for 14-3-3 eta was 0.2 ng/mL. The chi-square goodness-of-fit test was used to analyze the frequency of eta positivity in the RA population while kappa was calculated to compare the RA and non RA patients. Results Of the 91 RA patients, 75.8% were females and mean age was 58 (range 28- 90) years. The population was predominantly Hispanic (75%). In the non-RA group, 9% had psoriatic arthritis and 14% lupus, 73% were females,76% Hispanic and the mean age was 54 (range 19-93) years. In the RA population, none of group without RF or anti-CCP was positive for eta. For those with either RF or anti-CCP, the prevalence of eta positivity was 11.1% (95%CI 2.8-35.2%). For those with both RF and anti-CCP, the prevalence of eta positivity was 81.0% (95% CI 68.9-89.2%). All comparisons between groups were significant at p Conclusions Measurement of 14-3-3η complements RF and anti-CCP antibody tests in RA and may improve diagnostic sensitivity. Used in combination with other serological markers, 14-3-3 eta can increase identification of patients with RA. *Equal Contribution Disclosure of Interest None declared DOI 10.1136/annrheumdis-2014-eular.5776

Fatal Outcome in a Kidney-Pancreas Transplant Recipient With COVID-19

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly contagious pathogen causing the novel coronavirus disease 2019 (COVID-19), the ongoing unprecedented pandemic in 2020. SARS-CoV-2 primarily targets the respiratory systems, so acute respiratory distress syndrome is the major cause of death. Clinical courses of COVID-19 are variable and unpredictable, while some epidemiologic and clinical factors have been found to have a negative impact on the disease prognosis. Despite a growing report on clinical characteristics and prognosis of patients with COVID-19, the data in the special population, including transplant recipients, is still limited. Herein we report on the clinical features and fatal outcome of COVID-19 in a dual pancreas-kidney transplant recipient (with failure of the pancreas graft). Our case illustrates the similarities and differences of the COVID-19 disease course between transplant recipients and the general population. We proposed that the pre-existing T-cell dysfunction from the long-term use of immunosuppressive agents in organ transplant recipients adversely affects COVID-19 prognosis and worsens COVID-19 mortality.

Massive Spontaneous Hemothorax as a Complication of Apixaban Treatment

Abstract: Introduction. Hemothorax is usually related to chest or iatrogenic trauma from procedures such as central lines and thoracentesis. Spontaneous hemothorax is defined as pleural fluid hematocrit greater than 50% of serum hematocrit in absence of natural or iatrogenic trauma affecting the lung or pleural space. Coagulopathy secondary to anticoagulant use has been associated with spontaneous hemothorax. We present a case of spontaneous hemothorax in a patient taking apixaban for venous thromboembolism disease. To our knowledge, this is the first case report of apixaban as a cause of spontaneous hemothorax. Case Presentation. A 56-year-old woman with end-stage renal disease (ESRD) was diagnosed with upper extremity deep vein thrombosis (DVT) one month prior to presentation and was started on apixaban presented with dyspnea and left-sided pleuritic chest pain for two weeks. She was found to have left-sided large pleural effusion which was diagnosed as hemothorax. Other etiologies for spontaneous hemothorax were excluded and drainage by 12-French pigtail catheter achieved total resolution of hemothorax in three days. Discussion. Apixaban is a DOAC used to prevent stroke or thromboembolic events in patients with nonvalvular atrial fibrillation and to prevent recurrent venous thromboembolic disease. Events such as gastrointestinal, intracranial, and soft tissue bleeding have been well-documented. However, bleeding manifestation as hemothorax is seldom reported. Our patient presented with isolated left-sided large pleural effusion which was diagnosed as spontaneous hemothorax. 12-Fr pigtail catheter drainage was effective in the management of our patient and provided total resolution in three days. Conclusion. Spontaneous hemothorax is a rare complication of anticoagulant therapy and might not exhibit the usual radiological signs of traumatic hemothorax. Health care providers should have high index of suspicion for spontaneous hemothorax when evaluating new pleural effusion in patients receiving DOACs therapy. Drainage by small bore pigtail catheter might be as effective as larger chest tubes.