Linköping University

About: Linköping University is a education organization based out in Linköping, Sweden. It is known for research contribution in the topics: Population & Thin film. The organization has 15671 authors who have published 50013 publications receiving 1542189 citations.

Swedish experience-based value sets for EQ-5D health states

Abstract: Purpose To estimate Swedish experience-based value sets for EQ-5D health states using general population health survey data.

Prion strain discrimination using luminescent conjugated polymers.

Abstract: The occurrence of multiple strains of prions may reflect conformational variability of PrP(Sc), a disease-associated, aggregated variant of the cellular prion protein, PrP(C). Here we used luminescent conjugated polymers (LCPs), which emit conformation-dependent fluorescence spectra, for characterizing prion strains. LCP reactivity and emission spectra of brain sections discriminated among four immunohistochemically indistinguishable, serially mouse-passaged prion strains derived from sheep scrapie, chronic wasting disease (CWD), bovine spongiform encephalopathy (BSE), and mouse-adapted Rocky Mountain Laboratory scrapie prions. Furthermore, using LCPs we differentiated between field isolates of BSE and bovine amyloidotic spongiform encephalopathy, and identified noncongophilic deposits in prion-infected deer and sheep. We found that fibrils with distinct morphologies generated from chemically identical recombinant PrP yielded unique LCP spectra, suggesting that spectral characteristic differences resulted from distinct supramolecular PrP structures. LCPs may help to detect structural differences among discrete protein aggregates and to link protein conformational features with disease phenotypes.

A chloroplast DegP2 protease performs the primary cleavage of the photodamaged D1 protein in plant photosystem II

Abstract: Although light is the ultimate substrate in photosynthesis, it can also be harmful and lead to oxidative damage of the photosynthetic apparatus. The main target for light stress is the central oxygen-evolving photosystem II (PSII) and its D1 reaction centre protein. Degradation of the damaged D1 protein and its rapid replacement by a de novo synthesized copy represent the important repair mechanism of PSII crucial for plant survival under light stress conditions. Here we report the isolation of a single-copy nuclear gene from Arabidopsis thaliana, encoding a protease that performs GTP-dependent primary cleavage of the photodamaged D1 protein and hence catalysing the key step in the repair cycle in plants. This protease, designated DegP2, is a homologue of the prokaryotic Deg/Htr family of serine endopeptidases and is associated with the stromal side of the non-appressed region of the thylakoid membranes. Increased expression of DegP2 under high salt, desiccation and light stress conditions was measured at the protein level.

The concept of quality of life.

Abstract: Despite the fact that, in the current debate, quality of life is depicted as something very desirable, its concept is seldom specified. With regard to previous research into welfare and quality of life, a model of an overall concept of quality of life is presented here. The theoretical analysis ends in and is woven into an empirical application. The application consists of a prospective longitudinal investigation of alcoholics who receive disability pensions. This report is the first in a planned series from the research project "Abuse of alcohol--Disability pension--Quality of life".

Toward Massive MIMO 2.0: Understanding Spatial Correlation, Interference Suppression, and Pilot Contamination

Abstract: Since the seminal paper by Marzetta from 2010, Massive MIMO has changed from being a theoretical concept with an infinite number of antennas to a practical technology. The key concepts are adopted into the 5G New Radio Standard and base stations (BSs) with $M=64$ fully digital transceivers have been commercially deployed in sub-6GHz bands. The fast progress was enabled by many solid research contributions of which the vast majority assume spatially uncorrelated channels and signal processing schemes developed for single-cell operation. These assumptions make the performance analysis and optimization of Massive MIMO tractable but have three major caveats: 1) practical channels are spatially correlated; 2) large performance gains can be obtained by multicell processing, without BS cooperation; 3) the interference caused by pilot contamination creates a finite capacity limit, as $M\to \infty $ . There is a thin line of papers that avoided these caveats, but the results are easily missed. Hence, this tutorial article explains the importance of considering spatial channel correlation and using signal processing schemes designed for multicell networks. We present recent results on the fundamental limits of Massive MIMO, which are not determined by pilot contamination but the ability to acquire channel statistics. These results will guide the journey towards the next level of Massive MIMO, which we call “Massive MIMO 2.0”.