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Institution

Linköping University

EducationLinköping, Sweden
About: Linköping University is a education organization based out in Linköping, Sweden. It is known for research contribution in the topics: Population & Thin film. The organization has 15671 authors who have published 50013 publications receiving 1542189 citations.


Papers
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Journal ArticleDOI
TL;DR: In this paper, the interface between human tissue and implants of titanium and stainless steel has been studied and the changes of the oxide thickness and nature depend on the location of the implant in the body.

259 citations

Journal ArticleDOI
TL;DR: In this paper, the authors present a review of the features distinguishing HiPIMS from other deposition methods along with how they influence the deposition conditions, such as the plasma parameters and the sputtered material, as well as the resulting thin film properties.
Abstract: High-power impulse magnetron sputtering (HiPIMS) is a promising sputtering-based ionized physical vapor deposition technique and is already making its way to industrial applications. The major difference between HiPIMS and conventional magnetron sputtering processes is the mode of operation. In HiPIMS the power is applied to the magnetron (target) in unipolar pulses at a low duty factor (<10%) and low frequency (<10 kHz) leading to peak target power densities of the order of several kilowatts per square centimeter while keeping the average target power density low enough to avoid magnetron overheating and target melting. These conditions result in the generation of a highly dense plasma discharge, where a large fraction of the sputtered material is ionized and thereby providing new and added means for the synthesis of tailor-made thin films. In this review, the features distinguishing HiPIMS from other deposition methods will be addressed in detail along with how they influence the deposition conditions, such as the plasma parameters and the sputtered material, as well as the resulting thin film properties, such as microstructure, phase formation, and chemical composition. General trends will be established in conjunction to industrially relevant material systems to present this emerging technology to the interested reader.

258 citations

Journal ArticleDOI
26 Oct 2000-Oncogene
TL;DR: It is demonstrated that p53 is also a powerful inhibitor of human telomerase reverse transcriptase (hTERT), a key component for telomersase, and wt p53-triggered inhibition of hTERT/telomerase expression may reflect yet another mechanism of p 53-mediated tumor suppression.
Abstract: The p53 tumor suppressor protein inhibits the formation of tumors through induction of cell cycle arrest and/or apoptosis. In the present study we demonstrated that p53 is also a powerful inhibitor of human telomerase reverse transcriptase (hTERT), a key component for telomerase. Activation of either exogenous temperature-sensitive (ts) p53 in BL41 Burkitt lymphoma cells or endogenous wild type (wt) p53 at a physiological level in MCF-7 breast carcinoma cells triggered a rapid downregulation of hTERT mRNA expression, independently of the induction of the p53 target gene p21. Co-transfection of an hTERT promoter construct with wt p53 but not mutant p53 in HeLa cells inhibited the hTERT promoter activity. Furthermore, the activation of the hTERT promoter in Drosophila Schneider SL2 cells was completely dependent on the ectopic expression of Sp1 and was abrogated by wt p53. Finally, wt p53 inhibited Sp1 binding to the hTERT proximal promoter by forming a p53-Sp1 complex. Since activation of telomerase, widely observed in human tumor cell lines and primary tumors, is a critical step in tumorigenesis, wt p53-triggered inhibition of hTERT/telomerase expression may reflect yet another mechanism of p53-mediated tumor suppression. Our findings provide new insights into both the biological function of p53 and the regulation of hTERT/telomerase expression.

258 citations

Book ChapterDOI
01 Jan 2001
TL;DR: In this article, the authors analyse some of the major trends and policy challenges in this "new economy" from the viewpoint of technical innovation and competence building, and offer a new perspective on the transformation undertaken by firms, universities, and other agents.
Abstract: Knowledge is becoming increasingly important in contemporary economic systems, and economic growth and welfare depend on how promptly economic agents are able to exploit the benefits derived from technological innovations. In a landscape characterized by globalization, the contributors to this volume analyse some of the major trends and policy challenges in this "new economy" from the viewpoint of technical innovation and competence building, and offer a new perspective on the transformation undertaken by firms, universities, and other agents. They urge for a wider involvement of public policies to foster learning and innovation. The individual chapters report on the most significant policies adopted, and assess them in the light of the European experience in comparison with that of the USA and Japan. They are primarily based on research pursued under the European Commissionʹs Targeted Socio-Economic Research (TSER) programme.

258 citations

Journal ArticleDOI
TL;DR: The inevitable diffusion of hydrogen peroxide into iron-rich lysosomes causes the slow oxidative formation of lipofuscin in long-lived postmitotic cells, resulting in depressed autophagy and the accumulation of malfunctioning mitochondria and proteins with consequent cellular dysfunction.

257 citations


Authors

Showing all 15844 results

NameH-indexPapersCitations
Rui Zhang1512625107917
Jun Lu135152699767
Jean-Luc Brédas134102685803
Lars Wallentin12476761020
S. Shankar Sastry12285886155
Gerhard Andersson11890249159
Olle Inganäs11362750562
Antonio Facchetti11160251885
Ray H. Baughman11061660009
Michel W. Barsoum10654360539
Louis J. Ignarro10633546008
Per Björntorp10538640321
Jan Lubinski10368952120
Magnus Johannesson10234240776
Barbara Riegel10150777674
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20241
202385
2022359
20213,190
20203,210
20193,029