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Institution

Linköping University

EducationLinköping, Sweden
About: Linköping University is a education organization based out in Linköping, Sweden. It is known for research contribution in the topics: Population & Thin film. The organization has 15671 authors who have published 50013 publications receiving 1542189 citations.


Papers
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Journal ArticleDOI
TL;DR: In this article, the authors describe and compare the purchasing process for advanced versus basic logistics services, with respect to service definitions, providers evaluations and contracts, and some specific observations are presented from the procurement of advanced third-party logistics services.

237 citations

Journal ArticleDOI
TL;DR: In this paper, service-dominant logic and institutional theory are used to examine innovation as a process that unfolds through changes in the institutional arrangements that govern resource integrati cation.

236 citations

Journal ArticleDOI
TL;DR: During naphthazarin-induced apoptosis, lysosomal destabilization (measured as release of cathepsin D) precedes release of cytochrome c, loss of delta psi(m), and morphologic alterations, which shows apoptosis could be inhibited by pretreatment with pepstatin A.

236 citations

Journal ArticleDOI
TL;DR: In this article, the development of decision support tools for dynamic ambulance relocation and automatic ambulance dispatching is described, where the objective is to find new locations for some of the ambulances, to increase the preparedness in the area of responsibility.
Abstract: In this paper, the development of decision support tools for dynamic ambulance relocation and automatic ambulance dispatching is described. The ambulance dispatch problem is to choose which ambulance to send to a patient. The dynamic ambulance relocation problem occurs in the operational control of ambulances. The objective is to find new locations for some of the ambulances, to increase the preparedness in the area of responsibility. Preparedness is a way of evaluating the ability to serve potential patients with ambulances now and in the future. Computational tests using a simulation model show that the tools are beneficial in reducing the waiting periods for the patients.

236 citations

Journal ArticleDOI
TL;DR: Overall, it is becoming increasingly clear that the environment plays an important role in dissemination of antibiotic resistance; further studies are needed to elucidate key aspects of this process.
Abstract: Antibiotic resistance is a growing problem which threatens modern healthcare globally. Resistance has traditionally been viewed as a clinical problem, but recently non-clinical environments have been highlighted as an important factor in the dissemination of antibiotic resistance genes (ARGs). Horizontal gene transfer (HGT) events are likely to be common in aquatic environments; integrons in particular are well suited for mediating environmental dissemination of ARGs. A growing body of evidence suggests that ARGs are ubiquitous in natural environments. Particularly, elevated levels of ARGs and integrons in aquatic environments are correlated to proximity to anthropogenic activities. The source of this increase is likely to be routine discharge of antibiotics and resistance genes, for example, via wastewater or run-off from livestock facilities and agriculture. While very high levels of antibiotic contamination are likely to select for resistant bacteria directly, the role of sub-inhibitory concentrations of antibiotics in environmental antibiotic resistance dissemination remains unclear. In vitro studies have shown that low levels of antibiotics can select for resistant mutants and also facilitate HGT, indicating the need for caution. Overall, it is becoming increasingly clear that the environment plays an important role in dissemination of antibiotic resistance; further studies are needed to elucidate key aspects of this process. Importantly, the levels of environmental antibiotic contamination at which resistant bacteria are selected for and HGT is facilitated at should be determined. This would enable better risk analyses and facilitate measures for preventing dissemination and development of antibiotic resistance in the environment. Keywords: antibiotic resistance; antibiotics; environment; horizontal gene transfer; integrons (Published: 8 September 2015) Citation: Infection Ecology and Epidemiology 2015, 5: 28564 - http://dx.doi.org/10.3402/iee.v5.28564

235 citations


Authors

Showing all 15844 results

NameH-indexPapersCitations
Rui Zhang1512625107917
Jun Lu135152699767
Jean-Luc Brédas134102685803
Lars Wallentin12476761020
S. Shankar Sastry12285886155
Gerhard Andersson11890249159
Olle Inganäs11362750562
Antonio Facchetti11160251885
Ray H. Baughman11061660009
Michel W. Barsoum10654360539
Louis J. Ignarro10633546008
Per Björntorp10538640321
Jan Lubinski10368952120
Magnus Johannesson10234240776
Barbara Riegel10150777674
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20241
202385
2022359
20213,190
20203,210
20193,029