Institution
Linköping University
Education•Linköping, Sweden•
About: Linköping University is a education organization based out in Linköping, Sweden. It is known for research contribution in the topics: Population & Thin film. The organization has 15671 authors who have published 50013 publications receiving 1542189 citations.
Topics: Population, Thin film, Poison control, Health care, Photoluminescence
Papers published on a yearly basis
Papers
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TL;DR: It has been suggested that a reduced microbial stimulation during infancy and early childhood would result in a slower postnatal maturation of the immune system and development of an optimal balance between TH1‐ and TH2‐like immunity.
Abstract: Background
The prevalence of allergic diseases seems to have increased particularly over the past 35–40 years. Furthermore, allergic disease is less common among children in the formerly socialist countries of central and Eastern Europe as compared with Western Europe. It has been suggested that a reduced microbial stimulation during infancy and early childhood would result in a slower postnatal maturation of the immune system and development of an optimal balance between TH1- and TH2-like immunity.
Aims
To test the hypothesis that allergic disease among children may be associated with differences in their intestinal microflora in two countries with a low (Estonia) and a high (Sweden) prevalence of allergy.
Methods
From a prospective study of the development of allergy in relation to environmental factors, 29 Estonian and 33 Swedish 2-year-old children were selected. They were either nonallergic (n = 36) or had a confirmed diagnosis of allergy (n = 27) as verified by typical history and at least one positive skin prick test to egg or cow's milk. Weighed samples of faeces were serially diluted (10−2–10−9) and grown under anaerobic conditions. The counts of the various genera and species were calculated for each child. In addition, the relative amounts of the particular microbes were expressed as a proportion of the total count.
Results
The allergic children in Estonia and Sweden were less often colonized with lactobacilli (P < 0.01), as compared with the nonallergic children in the two countries. In contrast, the allergic children harboured higher counts of aerobic micro-organisms (P < 0.05), particularly coliforms (P < 0.01) and Staphylococcus aureus (P < 0.05). The proportions of aerobic bacteria of the intestinal flora were also higher in the allergic children (P < 0.05), while the opposite was true for anaerobes (P < 0.05). Similarly, in the allergic children the proportions of coliforms were higher (P < 0.05) and bacteroides lower (P < 0.05) than in the nonallergic children.
Conclusions
Differences in the indigenous intestinal flora might affect the development and priming of the immune system in early childhood, similar to what has been shown in rodents. The role of intestinal microflora in relation to the development of infant immunity and the possible consequences for allergic diseases later in life requires further study, particularly as it would be readily available for intervention as a means for primary prevention of allergy by the administration of probiotic bacteria.
931 citations
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TL;DR: Diltiazem was as effective as treatment based on diuretics, beta-blockers, or both in preventing the combined primary endpoint of all stroke, myocardial infarction, and other cardiovascular death.
923 citations
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TL;DR: It is found that peptide and protein hormones in secretory granules of the endocrine system are stored in an amyloid-like cross–β-sheet–rich conformation, which means functional amyloids in the pituitary and other organs can contribute to normal cell and tissue physiology.
Abstract: Amyloids are highly organized cross–β-sheet–rich protein or peptide aggregates that are associated with pathological conditions including Alzheimer’s disease and type II diabetes. However, amyloids may also have a normal biological function, as demonstrated by fungal prions, which are involved in prion replication, and the amyloid protein Pmel17, which is involved in mammalian skin pigmentation. We found that peptide and protein hormones in secretory granules of the endocrine system are stored in an amyloid-like cross–β-sheet–rich conformation. Thus, functional amyloids in the pituitary and other organs can contribute to normal cell and tissue physiology.
907 citations
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TL;DR: A critical review of the M(n + 1)AX(n) phases from a materials science perspective is given in this article, where the authors discuss the potential for low-temperature synthesis, which is essential for deposition of MAX phases onto technologically important substrates.
905 citations
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TL;DR: In this paper, regional and global lake methane emissions, contributing to the greenhouse effect, are poorly known, and the authors develop a method to identify hot spots of methane production in the landscape.
Abstract: [ 1] Lake sediments are "hot spots'' of methane production in the landscape. However, regional and global lake methane emissions, contributing to the greenhouse effect, are poorly known. We develop ...
902 citations
Authors
Showing all 15844 results
Name | H-index | Papers | Citations |
---|---|---|---|
Rui Zhang | 151 | 2625 | 107917 |
Jun Lu | 135 | 1526 | 99767 |
Jean-Luc Brédas | 134 | 1026 | 85803 |
Lars Wallentin | 124 | 767 | 61020 |
S. Shankar Sastry | 122 | 858 | 86155 |
Gerhard Andersson | 118 | 902 | 49159 |
Olle Inganäs | 113 | 627 | 50562 |
Antonio Facchetti | 111 | 602 | 51885 |
Ray H. Baughman | 110 | 616 | 60009 |
Michel W. Barsoum | 106 | 543 | 60539 |
Louis J. Ignarro | 106 | 335 | 46008 |
Per Björntorp | 105 | 386 | 40321 |
Jan Lubinski | 103 | 689 | 52120 |
Magnus Johannesson | 102 | 342 | 40776 |
Barbara Riegel | 101 | 507 | 77674 |