Institution
Linköping University
Education•Linköping, Sweden•
About: Linköping University is a education organization based out in Linköping, Sweden. It is known for research contribution in the topics: Population & Thin film. The organization has 15671 authors who have published 50013 publications receiving 1542189 citations.
Topics: Population, Thin film, Poison control, Health care, Photoluminescence
Papers published on a yearly basis
Papers
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TL;DR: In this article, the authors demonstrate the correlation between microstructure and mechanical as well as tribological properties of hard ceramic coatings and demonstrate that nanostructure dependent hardness increase (compared to hardness of the bulk counterparts) sustains higher annealing temperatures than hardness increase due to an increased density of point-and/or line-defects.
820 citations
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University of Cambridge1, University of Kiel2, University of East Anglia3, University of Copenhagen4, University of Manchester5, Karolinska Institutet6, Maastricht University7, Wellcome Trust Sanger Institute8, Trinity College, Dublin9, University of Paris10, University of Birmingham11, Charles University in Prague12, University College London13, University of Parma14, University of Jena15, Lund University16, University of Glasgow17, Imperial College London18, GlaxoSmithKline19, Linköping University20, Ruhr University Bochum21, University of Erlangen-Nuremberg22, Medical University of Vienna23
TL;DR: This study confirms that the pathogenesis of ANCA-associated vasculitis has a genetic component, shows genetic distinctions between granulomatosis with polyang iitis and microscopic polyangiitis that are associated with ANCA specificity, and suggests that the response against the autoantigen proteinase 3 is a central pathogenic feature ofproteinase 3 ANCA -associated vasulitis.
Abstract: BACKGROUND Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a severe condition encompassing two major syndromes: granulomatosis with polyangiitis (formerly known as Wegener's granulomatosis) and microscopic polyangiitis. Its cause is unknown, and there is debate about whether it is a single disease entity and what role ANCA plays in its pathogenesis. We investigated its genetic basis. METHODS A genomewide association study was performed in a discovery cohort of 1233 U. K. patients with ANCA-associated vasculitis and 5884 controls and was replicated in 1454 Northern European case patients and 1666 controls. Quality control, population stratification, and statistical analyses were performed according to standard criteria. RESULTS We found both major-histocompatibility-complex (MHC) and non-MHC associations with ANCA-associated vasculitis and also that granulomatosis with polyangiitis and microscopic polyangiitis were genetically distinct. The strongest genetic associations were with the antigenic specificity of ANCA, not with the clinical syndrome. Anti-proteinase 3 ANCA was associated with HLA-DP and the genes encoding alpha(1)-antitrypsin (SERPINA1) and proteinase 3 (PRTN3) (P = 6.2x10(-89), P = 5.6x10(-12), and P = 2.6x10(-7), respectively). Anti-myeloperoxidase ANCA was associated with HLA-DQ (P = 2.1x10(-8)). CONCLUSIONS This study confirms that the pathogenesis of ANCA-associated vasculitis has a genetic component, shows genetic distinctions between granulomatosis with polyangiitis and microscopic polyangiitis that are associated with ANCA specificity, and suggests that the response against the autoantigen proteinase 3 is a central pathogenic feature of proteinase 3 ANCA-associated vasculitis. These data provide preliminary support for the concept that proteinase 3 ANCA-associated vasculitis and myeloperoxidase ANCA-associated vasculitis are distinct autoimmune syndromes. (Funded by the British Heart Foundation and others.)
816 citations
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TL;DR: In this article, the microstructures of thin films of TiN are reviewed and correlated to physical properties such as the electrical resistivity and the hardness of the films, and the origin of the various micro-structures that are obtained is also discussed in terms of the growth conditions used.
816 citations
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TL;DR: How microbiota development in infants is affected by mode of delivery is addressed, and differences in colonisation patterns to the maturation of a balanced Th1/Th2 immune response are related to.
Abstract: Objective The early intestinal microbiota exerts important stimuli for immune development, and a reduced microbial exposure as well as caesarean section (CS) has been associated with the developmen ...
810 citations
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TL;DR: In this article, the authors provide a brief introduction to autophagy and apoptosis pathways focusing on the role of mitochondria and lysosomes, and discuss different ways that autophag and apoptotic modulation may be employed for therapeutic intervention during the maintenance of neurodegenerative disorders.
808 citations
Authors
Showing all 15844 results
Name | H-index | Papers | Citations |
---|---|---|---|
Rui Zhang | 151 | 2625 | 107917 |
Jun Lu | 135 | 1526 | 99767 |
Jean-Luc Brédas | 134 | 1026 | 85803 |
Lars Wallentin | 124 | 767 | 61020 |
S. Shankar Sastry | 122 | 858 | 86155 |
Gerhard Andersson | 118 | 902 | 49159 |
Olle Inganäs | 113 | 627 | 50562 |
Antonio Facchetti | 111 | 602 | 51885 |
Ray H. Baughman | 110 | 616 | 60009 |
Michel W. Barsoum | 106 | 543 | 60539 |
Louis J. Ignarro | 106 | 335 | 46008 |
Per Björntorp | 105 | 386 | 40321 |
Jan Lubinski | 103 | 689 | 52120 |
Magnus Johannesson | 102 | 342 | 40776 |
Barbara Riegel | 101 | 507 | 77674 |