Linköping University

About: Linköping University is a education organization based out in Linköping, Sweden. It is known for research contribution in the topics: Population & Thin film. The organization has 15671 authors who have published 50013 publications receiving 1542189 citations.

Importance of disrupted intestinal barrier in inflammatory bowel diseases

Abstract: The current paradigm of inflammatory bowel diseases (IBD), both Crohn's disease (CD) and ulcerative colitis (UC), involves the interaction between environmental factors in the intestinal lumen and inappropriate host immune responses in genetically predisposed individuals. The intestinal mucosal barrier has evolved to maintain a delicate balance between absorbing essential nutrients while preventing the entry and responding to harmful contents. In IBD, disruptions of essential elements of the intestinal barrier lead to permeability defects. These barrier defects exacerbate the underlying immune system, subsequently resulting in tissue damage. The epithelial phenotype in active IBD is very similar in CD and UC. It is characterized by increased secretion of chloride and water, leading to diarrhea, increased permeability via both the transcellular and paracellular routes, and increased apoptosis of epithelial cells. The main cytokine that seems to drive these changes is tumor necrosis factor alpha in CD, whereas interleukin (IL)-13 may be more important in UC. Therapeutic restoration of the mucosal barrier would provide protection and prevent antigenic overload due to intestinal “leakiness.” Here we give an overview of the key players of the intestinal mucosal barrier and review the current literature from studies in humans and human systems on mechanisms underlying mucosal barrier dysfunction in IBD. (Inflamm Bowel Dis 2011;)

A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate

Abstract: It is now established that the transcription factors E2A, EBF1 and Foxo1 have critical roles in B cell development. Here we show that E2A and EBF1 bound regulatory elements present in the Foxo1 locus. E2A and EBF1, as well as E2A and Foxo1, in turn, were wired together by a vast spectrum of cis-regulatory sequences. These associations were dynamic during developmental progression. Occupancy by the E2A isoform E47 directly resulted in greater abundance, as well as a pattern of monomethylation of histone H3 at lysine 4 (H3K4) across putative enhancer regions. Finally, we divided the pro-B cell epigenome into clusters of loci with occupancy by E2A, EBF and Foxo1. From this analysis we constructed a global network consisting of transcriptional regulators, signaling and survival factors that we propose orchestrates B cell fate.

The Innovating Region: Toward a Theory of Knowledge-Based Regional Development

Abstract: This paper sets forth a model of knowledge-based regional development conceived as a set of multi-linear dynamics, based on alternative technological paradigms. Utilizing longitudinal data from a Swedish region, and international comparisons, four stages of development are identified: Inception, Implementation, Consolidation and Renewal. Innovation policy is created 'bottom-up' as an outcome of 'collective entrepreneurship' through collaboration among business, government and academic actors - the 'triple helix'. The key event is the creation of an entrepreneurial university, whether from an existing academic base or a new foundation, which takes initiatives together with government and industry to create a support structure for firm formation and regional growth. The result of these initiatives is a self-sustaining dynamic in which the role of academia and government appears to recede as industrial actors come to the fore and a lineage of firms is created. Nevertheless, as one technological paradigm is exhausted and another one is needed as the base for new economic activity, the role of academia and government comes to the fore again in creating the conditions for the next wave of innovation.

Calculations of near-edge x-ray-absorption spectra of gas-phase and chemisorbed molecules by means of density-functional and transition-potential theory

Abstract: We explore the utility of density-functional theory ~DFT! in conjunction with the transition-potential ~TP! method to simulate x-ray-absorption spectra Calculations on a set of small carbon-containing molecules and chemisorbed species show that this provides a viable option for obtaining excitation energies and oscillator strengths close to the experimental accuracy of core-valence transitions Systematic variations in energy positions and intensities of the different spectra in the test series have been investigated, and comparison is made with respect to the static exchange-, self-consistent-field, and explicit electron-correlation methods The choice between standard exchange-correlation functionals is shown to be of little consequence for the valence resonant, here p*, parts of the x-ray-absorption spectra, while the long-range behavior of presently available functionals is found not to be completely satisfactory for Rydberg-like transitions Implementing a basis set augmentation technique, one finds that DFT methods still account well for most of the salient features in the near-edge x-ray-absorption spectra, save for the multielectron transitions in the near continuum, and for some loss of Rydberg structure For clusters modeling surface adsorbates, the DFT transition potential method reproduces well the spectral compression and intensity reduction for the valence level absorption compared to the free phase, provided fairly large clusters are taken into account While for near-edge x-ray-absorption fine-structure ~NEXAFS! spectra of free molecules the DFT-TP and Hartree-Fock/static exchange methods have complementary advantages, the DFT-TP method is clearly to be preferred when using clusters to simulate NEXAFS spectra of surface adsorbates @S0163-1829~98!00136-2#

Innovation system analyses and sustainability transitions: Contributions and suggestions for research

Abstract: This paper argues (1) that technology-specific policies are necessary if we are to meet the climate challenge and (2) that a main contribution of innovation system (IS) analysis to the study of sustainability transitions is that it allows policy makers to identify the processes and components in a system where intervention is likely to matter most. We demonstrate that an IS framework can identify a diverse set of system weaknesses in the field of environmental innovation and identify five venues for further research that can help strengthen the framework and improve its application to environmental innovations.