Institution
Lithuanian University of Health Sciences
Education•Kaunas, Lithuania•
About: Lithuanian University of Health Sciences is a education organization based out in Kaunas, Lithuania. It is known for research contribution in the topics: Population & Health care. The organization has 3565 authors who have published 4086 publications receiving 78384 citations.
Topics: Population, Health care, Anxiety, Cancer, Single-nucleotide polymorphism
Papers published on a yearly basis
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Wellcome Trust Sanger Institute1, Broad Institute2, University of Groningen3, University of Pittsburgh4, Cedars-Sinai Medical Center5, Yale University6, University of Cambridge7, University of Chicago8, Harvard University9, Katholieke Universiteit Leuven10, University of Liège11, King's College London12, Université de Montréal13, New Jersey Institute of Technology14, Cleveland Clinic15, Peninsula College of Medicine and Dentistry16, Université libre de Bruxelles17, Aarhus University18, University of Adelaide19, University of Kiel20, Flinders University21, McGill University22, Ludwig Maximilian University of Munich23, Charité24, Icahn School of Medicine at Mount Sinai25, University of Bonn26, Karolinska Institutet27, Torbay Hospital28, University of Auckland29, Christchurch Hospital30, Imperial College London31, Queen's University32, University of Oslo33, Lithuanian University of Health Sciences34, Emory University35, Casa Sollievo della Sofferenza36, Ghent University37, University of Western Australia38, University of Edinburgh39, Queensland Health40, Newcastle University41, University of Dundee42, University of Manchester43, University of Amsterdam44, University of Maribor45, Royal Hospital for Sick Children46, Guy's and St Thomas' NHS Foundation Trust47, QIMR Berghofer Medical Research Institute48, Norfolk and Norwich University Hospital49, Leiden University50, Technische Universität München51, University of Toronto52, University of Pennsylvania53, Johns Hopkins University54, University of Queensland55
TL;DR: A meta-analysis of Crohn’s disease and ulcerative colitis genome-wide association scans is undertaken, followed by extensive validation of significant findings, with a combined total of more than 75,000 cases and controls.
Abstract: Crohn's disease and ulcerative colitis, the two common forms of inflammatory bowel disease (IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other populations. Genome-wide association studies and subsequent meta-analyses of these two diseases as separate phenotypes have implicated previously unsuspected mechanisms, such as autophagy, in their pathogenesis and showed that some IBD loci are shared with other inflammatory diseases. Here we expand on the knowledge of relevant pathways by undertaking a meta-analysis of Crohn's disease and ulcerative colitis genome-wide association scans, followed by extensive validation of significant findings, with a combined total of more than 75,000 cases and controls. We identify 71 new associations, for a total of 163 IBD loci, that meet genome-wide significance thresholds. Most loci contribute to both phenotypes, and both directional (consistently favouring one allele over the course of human history) and balancing (favouring the retention of both alleles within populations) selection effects are evident. Many IBD loci are also implicated in other immune-mediated disorders, most notably with ankylosing spondylitis and psoriasis. We also observe considerable overlap between susceptibility loci for IBD and mycobacterial infection. Gene co-expression network analysis emphasizes this relationship, with pathways shared between host responses to mycobacteria and those predisposing to IBD.
4,094 citations
Mariachiara Di Cesare1, Mariachiara Di Cesare2, James Bentham2, Gretchen A Stevens3 +738 more•Institutions (60)
TL;DR: The posterior probability of meeting the target of halting by 2025 the rise in obesity at its 2010 levels, if post-2000 trends continue, is calculated.
3,766 citations
TL;DR: In this article, the authors used a Bayesian hierarchical model to estimate trends in diabetes prevalence, defined as fasting plasma glucose of 7.0 mmol/L or higher, or history of diagnosis with diabetes, or use of insulin or oral hypoglycaemic drugs in 200 countries and territories in 21 regions, by sex and from 1980 to 2014.
2,782 citations
Alexandria University1, American University of Beirut2, Tehran University of Medical Sciences3, University of the West Indies4, Centers for Disease Control and Prevention5, University of Kinshasa6, Wageningen University and Research Centre7, Cancer Research UK8, University of Oxford9, University of Pennsylvania10, University of Otago11, Newcastle University12, Lithuanian University of Health Sciences13, Medical Research Council14, All India Institute of Medical Sciences15, National Institutes of Health16, Mahidol University17, South African Medical Research Council18, RMIT University19, Deakin University20, Monash University21, World Health Organization22, International Agency for Research on Cancer23
1,911 citations
TL;DR: The number of adults with raised blood pressure increased from 594 million in 1975 to 1·13 billion in 2015, with the increase largely in low-income and middle-income countries, and the contributions of changes in prevalence versus population growth and ageing to the increase.
1,573 citations
Authors
Showing all 3587 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Matthew J. Budoff | 125 | 1449 | 68115 |
| Andre Franke | 115 | 682 | 55481 |
| Mark J. Nieuwenhuijsen | 107 | 647 | 49080 |
| Dietger Niederwieser | 97 | 727 | 44324 |
| Ronald S. Swerdloff | 91 | 430 | 32525 |
| Christina Wang | 88 | 422 | 27941 |
| Renate B. Schnabel | 76 | 301 | 20519 |
| Heriberto Rodriguez-Martinez | 68 | 486 | 16611 |
| Alon Harris | 63 | 476 | 13346 |
| Reinoud Gosens | 47 | 220 | 6735 |
| Anders Johannisson | 47 | 185 | 7046 |
| Feliksas F. Bukauskas | 46 | 100 | 7463 |
| Otto Robertsson | 43 | 128 | 6474 |
| Arvydas Usas | 42 | 83 | 6645 |
| Limas Kupčinskas | 41 | 203 | 12713 |