London Bridge Hospital

About: London Bridge Hospital is a healthcare organization based out in London, United Kingdom. It is known for research contribution in the topics: Antiphospholipid syndrome & Systemic lupus erythematosus. The organization has 107 authors who have published 122 publications receiving 4523 citations.

Starting aid for use in swimming

Abstract: A starting aid for use in swimming comprising a platform with a leading edge (14) wherein said platform is configured to be disposed with said leading edge adjacent to an edge of a swimming pool said aid further comprising a surface, configured for attachment to the platform, located behind said leading edge and upwardly inclined with respect to said platform, for a swimmer to push against with one foot whilst diving from the platform.

Hughes syndrome (antiphospholipid syndrome) and myocardial infarction

Abstract: Hughes syndrome (the antiphospholipid syndrome, APS) first described in clinical detail in 1983, is characterised by thrombosis, migraine, recurrent miscarriage and the presence of circulating antiphospholipid antibodies (1,2).

Targeted temperature management in acute liver failure: A systematic review.

Abstract: BACKGROUND Targeted temperature management is the modern term for therapeutic hypothermia, where cooling is induced by intensive care clinicians to achieve body temperatures below 36°C Its use in acute liver failure to improve refractory intracranial hypertension and patient outcomes is not supported by strong quality evidence AIM This systematic review aims to determine if targeted temperature management improves patient outcome as opposed to normothermia in acute liver failure METHODS A computerized and systematic search of six academic and medical databases was conducted using the following keywords: "acute liver failure", "fulminant hepatic injury", "targeted temperature management", "therapeutic hypothermia", and "cooling" Broad criteria were applied to include all types of primary observational studies, from case reports to randomized controlled trials Standardized tools were used throughout to critically appraise and extract data FINDINGS Nine studies published between 1999 and 2016 were included Early observational studies suggest a benefit of targeted temperature management in the treatment of refractory intracranial hypertension and in survival More recent controlled studies do not show such a benefit in the prevention of intracranial hypertension All studies revealed that the incidence of coagulopathy is not higher in patients treated with targeted temperature management There remains some uncertainty regarding the increased risk of infection and dysrhythmias Heterogeneity was found between study types, design, sample sizes, and quality CONCLUSION Although it does not significantly improve survival, targeted temperature management is efficient in treating episodes of intracranial hypertension and stabilizing an unstable critical care patient without increasing the risk of bleeding It does not, however, prevent intracranial hypertension Data heterogeneity may explain the contradictory findings RELEVANCE TO CLINICAL PRACTICE Controlled studies are needed to elucidate the true clinical benefit of targeted temperature management in improving patient outcome