Institution
London Bridge Hospital
Healthcare•London, United Kingdom•
About: London Bridge Hospital is a healthcare organization based out in London, United Kingdom. It is known for research contribution in the topics: Antiphospholipid syndrome & Systemic lupus erythematosus. The organization has 107 authors who have published 122 publications receiving 4523 citations.
Topics: Antiphospholipid syndrome, Systemic lupus erythematosus, Artificial intelligence, Lupus erythematosus, Catheter ablation
Papers published on a yearly basis
Papers
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TL;DR: Erectile dysfunction is a major problem with an increasing prevalence in cardiovascular high‐risk patients due to its association with cardiovascular risk factors and drugs used for evidence‐based treatment of cardiovascular diseases are reported to decrease erectile function.
Abstract: AIMS Erectile dysfunction is a major problem with an increasing prevalence in cardiovascular high-risk patients due to its association with cardiovascular risk factors. Drugs used for evidence-based treatment of cardiovascular diseases have been reported to decrease erectile function, but possible mechanisms are poorly characterised. METHODS MEDLINE, EMBASE and Cochrane Registry search were performed including manuscripts until January 2010. Searching terms are: 'erectile dysfunction or impotence' in combination with 'ACE-inhibitors', 'angiotensin', 'beta-blockers', 'calcium antagonist' and 'diuretics'. Animal studies, letters, reviews, case-reports and manuscripts other than English language and trials dealing with combination treatment are excluded. RESULTS Analysis of literature revealed five epidemiological trials evaluating the effect of different cardiovascular drugs on erectile function. There were eight trials evaluating the effect of beta-blockers, five trials evaluating the effect of ace-inhibitors or angiotensin-receptor-blockers and one trial evaluating the effect of diuretics on erectile function. Results of these trials demonstrate that only thiazide diuretics and beta-blockers except nebivolol may adversely influence erectile function. ACE-inhibitors, angiotensin-receptor-blockers and calcium-channel-blockers are reported to have no relevant or even a positive effect on erectile function. CONCLUSION Inappropriate patients' concerns about adverse effects of cardiovascular drugs on erectile function might limit the use of important medications in cardiovascular high-risk patients. Knowledge about the effects of drug-treatments on erectile function and about the major role of the endothelium in penile function might improve patients' adherence to evidence based treatment of cardiovascular diseases.
111 citations
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TL;DR: The present position paper focuses on the clinical and biological aspects of the safety of ICS and the available literature is reviewed in order to reach experimentally supported conclusions useful for asthma treatment.
Abstract: The commercially available inhaled corticosteroids (ICS) for asthma treatment are beclomethasone dipropionate (BDP), budesonide (BUD), unisolide (FLU), uticasone propionate (FP), mometasone furoate (MF), and triamcinolone acetonide (TA); most of them are also available as nasal sprays for the treatment of rhinitis. There is no longer any doubt of their effectiveness in both asthma and rhinitis. Since ICS are widely used in both adults and children, the issue of safety and the risk/bene®t ratio assume primary importance. The present position paper focuses on the clinical and biological aspects of the safety of ICS; therefore, the available literature is reviewed in order to reach experimentally supported conclusions useful for ÐÐÐÐÐÐÐ *Prepared by the Antiallergic Drugs Subcommittee of the European Academy of Allergology and Clinical Immunology (EAACI). This document represents the ``state of the art'', and is based on the literature available as of December 1998. The ef®cacy and safety of inhaled and nasal corticosteroids is a fast-changing ®eld; therefore, this position paper will be updated as frequently as required by new experimental evidence. Allergy 2000: 55: 16±33 Printed in UK. All rights reserved Copyright # Munksgaard 2000
105 citations
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01 Jan 2016TL;DR: There are two areas of the heart which can be affected – the heart valves, and the heart’s own coronary arteries.
Abstract: There are two areas of the heart which can be affected – the heart valves, and the heart’s own coronary arteries.
102 citations
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TL;DR: It is shown that subjects presenting with PFPS do have a tighter ITB, and future work should investigate this observation prospectively in order to determine whether a tight ITB is the cause or effect of PFPS.
87 citations
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TL;DR: Though technically challenging and demanding, the FVFG is an extremely useful salvage option and can facilitate limb reconstruction in the most complex of cases and covers the applied anatomy, indications, operative techniques, complications and donor-site morbidity.
Abstract: Bony defects caused by trauma, tumors, infection or congenital anomalies can present a significant surgical challenge. Free vascularised fibular bone grafts (FVFGs) have proven to be extremely effective in managing larger defects (longer than 6 cm) where other conventional grafts have failed. FVFGs also have a role in the treatment of avascular necrosis (AVN) of the femoral head, failed spinal fusions and complex arthrodeses. Due to the fact that they have their own blood supply, FVFGs are effective even in cases where there is poor vascularity at the recipient site, such as in infection and following radiotherapy. This article discusses the versatility of the FVFG and its successful application to a variety of different pathologies. It also covers the applied anatomy, indications, operative techniques, complications and donor-site morbidity. Though technically challenging and demanding, the FVFG is an extremely useful salvage option and can facilitate limb reconstruction in the most complex of cases.
81 citations
Authors
Showing all 107 results
Name | H-index | Papers | Citations |
---|---|---|---|
Graham R. V. Hughes | 73 | 239 | 25987 |
Graham Jackson | 65 | 426 | 16880 |
Michael Chapman | 56 | 365 | 11439 |
Richard J. Schilling | 54 | 321 | 11232 |
Jonathan Hill | 53 | 259 | 13899 |
John L. Hayward | 46 | 166 | 17691 |
Sujal R. Desai | 41 | 133 | 8174 |
Simon Sporton | 31 | 122 | 3473 |
Mark J. Earley | 31 | 116 | 3364 |
Bryn T. Williams | 29 | 169 | 3349 |
Gabriella Pichert | 28 | 54 | 4169 |
Rick Popert | 24 | 102 | 1791 |
Adnan Al-Kaisy | 20 | 49 | 1512 |
Henry Dushan Atkinson | 19 | 60 | 1074 |
J. Ponte | 16 | 29 | 936 |