Institution
Long Island Jewish Medical Center
Healthcare•New Hyde Park, New York, United States•
About: Long Island Jewish Medical Center is a healthcare organization based out in New Hyde Park, New York, United States. It is known for research contribution in the topics: Population & Cancer. The organization has 3382 authors who have published 3734 publications receiving 142441 citations. The organization is also known as: LIJMC.
Topics: Population, Cancer, Chronic lymphocytic leukemia, Medicine, Health care
Papers published on a yearly basis
Papers
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TL;DR: In this relatively brief study, the apparently increased comparative risk of agranulocytosis requires that the use of clozapine be limited to selected treatment-resistant patients.
Abstract: • The treatment of schizophrenic patients who fail to respond to adequate trials of neuroleptics is a major challenge. Clozapine, an atypical antipsychotic drug, has long been of scientific interest, but its clinical development has been delayed because of an associated risk of agranulocytosis. This report describes a multicenter clinical trial to assess clozapine's efficacy in the treatment of patients who are refractory to neuroleptics.DSM-IIIschizophrenics who had failed to respond to at least three different neuroleptics underwent a prospective, single-blind trial of haloperidol (mean dosage, 61 ±14 mg/d) for six weeks. Patients whose condition remained unimproved were then randomly assigned, in a double-blind manner, to clozapine (up to 900 mg/d) or chlorpromazine (up to 1800 mg/d) for six weeks. Two hundred sixty-eight patients were entered in the doubleblind comparison. When a priori criteria were used, 30% of the clozapine-treated patients were categorized as responders compared with 4% of chlorpromazine-treated patients. Clozapine produced significantly greater improvement on the Brief Psychiatric Rating Scale, Clinical Global Impression Scale, and Nurses' Observation Scale for Inpatient Evaluation; this improvement included "negative" as well as positive symptom areas. Although no cases of agranulocytosis occurred during this relatively brief study, in our view, the apparently increased comparative risk requires that the use of clozapine be limited to selected treatment-resistant patients.
3,842 citations
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TL;DR: The International Workshop on Chronic Lymphocytic Leukemia (IWCLL) to provide updated recommendations for the management of CLL in clinical trials and general practice is provided.
3,028 citations
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Broad Institute1, Emory University2, Cincinnati Children's Hospital Medical Center3, University of Colorado Boulder4, Harvard University5, University of Minnesota6, University of Toronto7, Women & Children's Hospital of Buffalo8, Boston Children's Hospital9, Mayo Clinic10, University of California, San Francisco11, Long Island Jewish Medical Center12, Children's Hospital of Philadelphia13, Children's Hospital of Eastern Ontario14, Nationwide Children's Hospital15, Howard Hughes Medical Institute16
TL;DR: Comparing the microbial signatures between the ileum, the rectum, and fecal samples indicates that at this early stage of disease, assessing the rectal mucosal-associated microbiome offers unique potential for convenient and early diagnosis of CD.
2,410 citations
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TL;DR: In view of the current trend of increasing and widespread use of chronic bisphosphonate therapy, the observation of an associated risk of osteonecrosis of the jaw should alert practitioners to monitor for this previously unrecognized potential complication.
1,964 citations
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TL;DR: This update contains revisions to the diagnosis and staging and management strategies and highlights the status of basic science research.
1,727 citations
Authors
Showing all 3386 results
Name | H-index | Papers | Citations |
---|---|---|---|
Jeffrey A. Lieberman | 145 | 706 | 85306 |
John M. Kane | 125 | 752 | 60886 |
Christoph U. Correll | 100 | 755 | 37523 |
Stefan G. Hofmann | 97 | 573 | 38474 |
Carol A. Tamminga | 90 | 636 | 32680 |
Bruce P. Hermann | 89 | 458 | 25714 |
Jack A. Elias | 89 | 324 | 30415 |
Terry E. Goldberg | 89 | 194 | 36143 |
Robert M. Bilder | 82 | 303 | 27009 |
Haichao Wang | 81 | 255 | 40235 |
Lily Hechtman | 78 | 169 | 19596 |
John Piacentini | 76 | 334 | 22889 |
Dipak K. Das | 75 | 327 | 17708 |
Andrew S. Greenberg | 74 | 191 | 25437 |
Howard Abikoff | 73 | 128 | 17941 |