Institution
Louisiana State University
Education•Baton Rouge, Louisiana, United States•
About: Louisiana State University is a education organization based out in Baton Rouge, Louisiana, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 40206 authors who have published 76587 publications receiving 2566076 citations. The organization is also known as: LSU & Louisiana State University and Agricultural and Mechanical College.
Topics: Population, Poison control, Wetland, Autism, Sediment
Papers published on a yearly basis
Papers
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TL;DR: A new BASIC exponential stripping program, ESTRIP, allows the relatively rapid calculation of initial polyexponential parameter estimates, as does the previously published FORTRAN IV program, CSTRIP.
336 citations
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TL;DR: Preneoplastic gastric lesions regress at a rate equal to the square of time in patients rendered free of H pylori infection, and are suggested to be treated and cured of their H plyori infection.
Abstract: Background: Helicobacter pylori infection induces progressive inflammatory changes in the gastric mucosa that may lead to gastric cancer. Understanding long term effects resulting from the cure of this infection is needed to design cancer prevention strategies. Methods: A cohort of 795 adults with preneoplastic gastric lesions was randomised to receive anti- H pylori treatment and/or antioxidants. At the end of six years of intervention, those who did not receive anti- H pylori treatment were offered it. Gastric biopsies were obtained at baseline, and at 3, 6, and 12 years. A histopathology score was utilised to document changes in gastric lesions. Non-linear mixed models were used to estimate the cumulative effect of H pylori clearance on histopathology scores adjusted for follow up time, interventions, and confounders. Results: Ninety seven per cent of subjects were H pylori positive at baseline, and 53% were positive at 12 years. Subjects accumulated 1703 person years free of infection. A multivariate model showed a significant regression in histopathology score as a function of the square of H pylori negative time. Subjects who were H pylori negative had 14.8% more regression and 13.7% less progression than patients who were positive at 12 years (p = 0.001). The rate of healing of gastric lesions occurred more rapidly as years free of infection accumulated, and was more pronounced in less advanced lesions. Conclusions: Preneoplastic gastric lesions regress at a rate equal to the square of time in patients rendered free of H pylori infection. Our findings suggest that patients with preneoplastic gastric lesions should be treated and cured of their H pylori infection.
336 citations
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TL;DR: In this paper, a micromechanical model that assesses a nonlinear coupling between statistically stored dislocations (SSDs) and geometrically necessary dislocation (GNDs) is used to derive an analytical form for the deformation-gradient-related intrinsic length-scale parameter in terms of measurable microstructural physical parameters.
335 citations
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TL;DR: These studies indicate that while there are significant quantitative differences in constitutive and induced expression of murine ICAM-1 and VCam-1, the kinetics and dose-response characteristics of the two adhesion molecules to TNF-alpha are qualitatively similar.
Abstract: The dual radiolabeled mAb technique was used to quantify the constitutive and induced expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in the microvasculature of different organs of the mouse The constitutive expression of both adhesion molecules varied significantly between tissues, with ICAM-1 levels consistently higher than VCAM-1 in all tissues studied Following systemic administration of endotoxin (LPS), an increased surface expression of both adhesion molecules occurred in most organs, with the largest increases for ICAM-1 (2 to 3x increase) noted in the heart, small intestine, and brain, while heart and small intestine exhibited the largest increases in LPS-induced VCAM-1 expression (2 to 5x increase) These responses occurred in the face of an unaltered expression of platelet endothelial cell adhesion molecule-1 (PECAM-1) in all tissues TNF-alpha also elicited an increased expression of both adhesion molecules, with initial increases noted at 2 to 5 h, peak levels at 5 to 9 h, and a sustained elevation above baseline at 24 h The TNF-alpha-induced increases in both ICAM-1 and VCAM-1 were dose dependent, with significant up-regulation noted at 5 microg/kg and maximal increases occurring at 10 to 25 microg/kg These studies indicate that while there are significant quantitative differences in constitutive and induced expression of murine ICAM-1 and VCAM-1, the kinetics and dose-response characteristics of the two adhesion molecules to TNF-alpha are qualitatively similar
335 citations
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TL;DR: The most severe floods in the Poyang Lake since 1950, and ranked in descending order of severity, occurred in 1998, 1995, 1954, 1983, 1992, 1973, and 1977.
Abstract: Poyang Lake in Jiangxi Province is the largest freshwater lake in China and is historically a region of significant floods. Annual events of peak lake stage and of severe floods have increased dramatically during the past few decades. This trend is related primarily to levee construction at the periphery of the lake and along the middle of the Changjiang (Yangtze River), which protects a large rural population. These levees reduce the area formerly available for floodwater storage resulting in higher lake stages during the summer flood season and catastrophic levee failures. The most severe floods in the Poyang Lake since 1950, and ranked in descending order of severity, occurred in 1998, 1995, 1954, 1983, 1992, 1973, and 1977. All of these floods occurred during or immediately following El Ni˜ no events, which are directly linked to rainfall in central China. The 2-year recurrence interval for maximum annual lake stage during El Ni˜ no years is 1.2 m higher than during non-El Ni˜ no years. The 10-year recurrence interval is 1.4 m higher during El Ni˜ no years than during non-El Ni˜ no years. Copyright 2006 Royal Meteorological Society.
335 citations
Authors
Showing all 40485 results
Name | H-index | Papers | Citations |
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H. S. Chen | 179 | 2401 | 178529 |
John A. Rogers | 177 | 1341 | 127390 |
Omar M. Yaghi | 165 | 459 | 163918 |
Barry M. Popkin | 157 | 751 | 90453 |
John E. Morley | 154 | 1377 | 97021 |
Claude Bouchard | 153 | 1076 | 115307 |
Ruth J. F. Loos | 142 | 647 | 92485 |
Ali Khademhosseini | 140 | 887 | 76430 |
Shanhui Fan | 139 | 1292 | 82487 |
Joseph E. LeDoux | 139 | 478 | 91500 |
Christopher T. Walsh | 139 | 819 | 74314 |
Kenneth A. Dodge | 138 | 468 | 79640 |
Steven B. Heymsfield | 132 | 679 | 77220 |
George A. Bray | 131 | 896 | 100975 |
Zhanhu Guo | 128 | 886 | 53378 |