Louisiana State University

About: Louisiana State University is a education organization based out in Baton Rouge, Louisiana, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 40206 authors who have published 76587 publications receiving 2566076 citations. The organization is also known as: LSU & Louisiana State University and Agricultural and Mechanical College.

Neuroprotectin D1 (NPD1): a DHA-derived mediator that protects brain and retina against cell injury-induced oxidative stress.

Abstract: The biosynthesis of oxygenated arachidonic acid messengers triggered by cerebral ischemia-reperfusion is preceded by an early and rapid phospholipase A2 activation reflected in free arachidonic and docosahexaenoic acid (DHA) accumulation. These fatty acids are released from membrane phospholipids. Both fatty acids are derived from dietary essential fatty acids; however, only DHA, the omega-3 polyunsaturated fatty acyl chain, is concentrated in phospholipids of various cells of brain and retina. Synaptic membranes and photoreceptors share the highest content of DHA of all cell membranes. DHA is involved in memory formation, excitable membrane function, photoreceptor cell biogenesis and function, and neuronal signaling, and has been implicated in neuroprotection. In addition, this fatty acid is required for retinal pigment epithelium cell (RPE) functional integrity. Here we provide an overview of the recent elucidation of a specific mediator generated from DHA that contributes at least in part to its biological significance. In oxidative stress-challenged human RPE cells and rat brain undergoing ischemia-reperfusion, 10,17S-docosatriene (neuroprotectin D1, NPD1) synthesis evolves. In addition, calcium ionophore A23187, IL-1beta, or the supply of DHA enhances NPD1 synthesis. A time-dependent release of endogenous free DHA followed by NPD1 formation occurs, suggesting that a phospholipase A2 releases the mediator's precursor. When NPD1 is infused during ischemia-reperfusion or added to RPE cells during oxidative stress, apoptotic DNA damage is down-regulated. NPD1 also up-regulates the anti-apoptotic Bcl-2 proteins Bcl-2 and BclxL and decreases pro-apoptotic Bax and Bad expression. Moreover, NPD1 inhibits oxidative stress-induced caspase-3 activation. NPD1 also inhibits IL-1beta-stimulated expression of COX-2. Overall, NPD1 protects cells from oxidative stress-induced apoptosis. Because photoreceptors are progressively impaired after RPE cell damage in retinal degenerative diseases, understanding of how these signals contribute to retinal cell survival may lead to the development of new therapeutic strategies. Moreover, NPD1 bioactivity demonstrates that DHA is not only a target of lipid peroxidation, but rather is the precursor to a neuroprotective signaling response to ischemia-reperfusion, thus opening newer avenues of therapeutic exploration in stroke, neurotrauma, spinal cord injury, and neurodegenerative diseases, such as Alzheimer disease, aiming to up-regulate this novel cell-survival signaling.

Asynchronous cooperative diversity

Abstract: Cooperative diversity, which employs multiple nodes for the simultaneous relaying of a given packet in wireless ad hoc networks, has been shown to be an effective means of improving diversity, and, hence, mitigating the detrimental effects of multipath fading. However, in previously proposed cooperative diversity schemes, it has been assumed that coordination among the relays allows for accurate symbol-level timing synchronization at the destination and orthogonal channel allocation, which can be quite costly in terms of signaling overhead in mobile ad hoc networks, which are often defined by their lack of a fixed infrastructure and the difficulty of centralized control. In this paper, cooperative diversity schemes are considered that do not require symbol-level timing synchronization or orthogonal channelization between the relays employed. In the process, a novel minimum mean-squared error (MMSE) receiver is designed for combining disparate inputs in the multiple-relay channel. Outage probability calculations and simulation results demonstrate the not unexpected significant performance gains of the proposed schemes over single-hop transmission, and, more importantly, demonstrate performance comparable to schemes requiring accurate symbol-level synchronization and orthogonal channelization

The accuracy of implant impressions: a systematic review.

Abstract: Statement of problem Various implant impression techniques, such as the splint, pick-up, and transfer techniques, have been introduced, and some techniques may be more accurate than others. Also, clinically, some factors, including the angulation or depth of implants, may affect the accuracy of the implant impressions. Purpose The purposes of this review were to: (1) investigate the accuracy of published implant impression techniques, and (2) examine the clinical factors affecting implant impression accuracy. Material and methods An electronic search was performed in June 2008 of MEDLINE, EMBASE, and Cochrane Library databases with the key words implant, implants, impression, and impressions. To be included, the study had to investigate the accuracy of implant impressions and be published in an English peer-reviewed journal. In addition, a hand search was performed to enrich the results for the time period from January 1980 to May 2008. After executing the search strategies, 41 articles were selected to be included in the review process. Results All of the selected articles were in vitro studies. Of the 17 studies that compared the accuracy between the splint and nonsplint techniques, 7 advocated the splint technique, 3 advocated the nonsplint technique, and 7 reported no difference. Fourteen studies compared the accuracy of pick-up and transfer impression techniques, and 5 showed more accurate impression with the pick-up techniques, 2 with the transfer technique, and 7 showed no difference. The number of implants affected the comparison of the pick-up and splint techniques. Eleven studies compared the accuracy of polyether and vinyl polysiloxane (VPS), and 10 of 11 reported no difference between the 2 materials. Four studies examined the effect of implant angulation on the accuracy of impressions. Two studies reported higher accuracy with straight implants, while the other 2 reported there was no angulation effect. Conclusions The review of abutment level or implant level internal connection implants indicated that more studies reported greater accuracy with the splint technique than with the nonsplint technique. For situations in which there were 3 or fewer implants, most studies showed no difference between the pick-up and transfer techniques, whereas for 4 or more implants, more studies showed higher accuracy with the pick-up technique. Polyether and VPS were the recommended materials for the implant impressions. (J Prosthet Dent 2008;100:285-291)

Catalytic aromatization of methane

Abstract: Recent developments in natural gas production technology have led to lower prices for methane and renewed interest in converting methane to higher value products Processes such as those based on syngas from methane reforming are being investigated Another option is methane aromatization, which produces benzene and hydrogen: 6CH4(g) → C6H6(g) + 9H2(g) ΔGor = +433 kJ mol−1 ΔHor = +531 kJ mol−1 Thermodynamic calculations for this reaction show that benzene formation is insignificant below ∼600 °C, and that the formation of solid carbon [C(s)] is thermodynamically favored at temperatures above ∼300 °C Benzene formation is insignificant at all temperatures up to 1000 °C when C(s) is included in the calculation of equilibrium composition Interestingly, the thermodynamic limitation on benzene formation can be minimized by the addition of alkanes/alkenes to the methane feed By far the most widely studied catalysts for this reaction are Mo/HZSM-5 and Mo/MCM-22 Benzene selectivities are generally between 60 and 80% at methane conversions of ∼10%, corresponding to net benzene yields of less than 10% Major byproducts include lower molecular weight hydrocarbons and higher molecular weight substituted aromatics However, carbon formation is inevitable, but the experimental findings show this can be kinetically limited by the use of H2 or oxidants in the feed, including CO2 or steam A number of reactor configurations involving regeneration of the carbon-containing catalyst have been developed with the goal of minimizing the cost of regeneration of the catalyst once deactivated by carbon deposition In this tutorial review we discuss the thermodynamics of this process, the catalysts used and the potential reactor configurations that can be applied