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Institution

Louisiana State University

EducationBaton Rouge, Louisiana, United States
About: Louisiana State University is a education organization based out in Baton Rouge, Louisiana, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 40206 authors who have published 76587 publications receiving 2566076 citations. The organization is also known as: LSU & Louisiana State University and Agricultural and Mechanical College.
Topics: Population, Poison control, Wetland, Autism, Sediment


Papers
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Journal ArticleDOI
TL;DR: In this paper, the authors pointed out that the formation of hypoxic areas has been exacerbated by any combination of interactions that increase primary production and accumulation of organic carbon leading to increased respiratory demand for oxygen below a seasonal or permanent pycnocline, and the consequences of eutrophication-induced hypoxia can be reversed if longterm, broad-scale, and persistent efforts to reduce substantial nutrient loads are developed and implemented.
Abstract: . Water masses can become undersaturated with oxygen when natural processes alone or in combination with anthropogenic processes produce enough organic carbon that is aerobically decomposed faster than the rate of oxygen re-aeration. The dominant natural processes usually involved are photosynthetic carbon production and microbial respiration. The re-supply rate is indirectly related to its isolation from the surface layer. Hypoxic water masses ( Hypoxia development and continuation in many areas of the world's coastal ocean is accelerated by human activities, especially where nutrient loading increased in the Anthropocene. This higher loading set in motion a cascading set of events related to eutrophication. The formation of hypoxic areas has been exacerbated by any combination of interactions that increase primary production and accumulation of organic carbon leading to increased respiratory demand for oxygen below a seasonal or permanent pycnocline. Nutrient loading is likely to increase further as population growth and resource intensification rises, especially with increased dependency on crops using fertilizers, burning of fossil fuels, urbanization, and waste water generation. It is likely that the occurrence and persistence of hypoxia will be even more widespread and have more impacts than presently observed. Global climate change will further complicate the causative factors in both natural and human-caused hypoxia. The likelihood of strengthened stratification alone, from increased surface water temperature as the global climate warms, is sufficient to worsen hypoxia where it currently exists and facilitate its formation in additional waters. Increased precipitation that increases freshwater discharge and flux of nutrients will result in increased primary production in the receiving waters up to a point. The interplay of increased nutrients and stratification where they occur will aggravate and accelerate hypoxia. Changes in wind fields may expand oxygen minimum zones onto more continental shelf areas. On the other hand, not all regions will experience increased precipitation, some oceanic water temperatures may decrease as currents shift, and frequency and severity of tropical storms may increase and temporarily disrupt hypoxia more often. The consequences of global warming and climate change are effectively uncontrollable at least in the near term. On the other hand, the consequences of eutrophication-induced hypoxia can be reversed if long-term, broad-scale, and persistent efforts to reduce substantial nutrient loads are developed and implemented. In the face of globally expanding hypoxia, there is a need for water and resource managers to act now to reduce nutrient loads to maintain, at least, the current status.

936 citations

Journal ArticleDOI
TL;DR: The basic biology of the fly is reviewed and models of human diseases and opportunities for therapeutic discovery for central nervous system disorders, inflammatory disorders, cardiovascular disease, cancer, and diabetes are discussed.
Abstract: The common fruit fly, Drosophila melanogaster, is a well studied and highly tractable genetic model organism for understanding molecular mechanisms of human diseases. Many basic biological, physiological, and neurological properties are conserved between mammals and D. melanogaster, and nearly 75% of human disease-causing genes are believed to have a functional homolog in the fly. In the discovery process for therapeutics, traditional approaches employ high-throughput screening for small molecules that is based primarily on in vitro cell culture, enzymatic assays, or receptor binding assays. The majority of positive hits identified through these types of in vitro screens, unfortunately, are found to be ineffective and/or toxic in subsequent validation experiments in whole-animal models. New tools and platforms are needed in the discovery arena to overcome these limitations. The incorporation of D. melanogaster into the therapeutic discovery process holds tremendous promise for an enhanced rate of discovery of higher quality leads. D. melanogaster models of human diseases provide several unique features such as powerful genetics, highly conserved disease pathways, and very low comparative costs. The fly can effectively be used for low- to high-throughput drug screens as well as in target discovery. Here, we review the basic biology of the fly and discuss models of human diseases and opportunities for therapeutic discovery for central nervous system disorders, inflammatory disorders, cardiovascular disease, cancer, and diabetes. We also provide information and resources for those interested in pursuing fly models of human disease, as well as those interested in using D. melanogaster in the drug discovery process.

931 citations

Proceedings ArticleDOI
07 Jun 2008
TL;DR: An automatic polyhedral source-to-source transformation framework that can optimize regular programs for parallelism and locality simultaneously simultaneously and is implemented into a tool to automatically generate OpenMP parallel code from C program sections.
Abstract: We present the design and implementation of an automatic polyhedral source-to-source transformation framework that can optimize regular programs (sequences of possibly imperfectly nested loops) for parallelism and locality simultaneously. Through this work, we show the practicality of analytical model-driven automatic transformation in the polyhedral model -- far beyond what is possible by current production compilers. Unlike previous works, our approach is an end-to-end fully automatic one driven by an integer linear optimization framework that takes an explicit view of finding good ways of tiling for parallelism and locality using affine transformations. The framework has been implemented into a tool to automatically generate OpenMP parallel code from C program sections. Experimental results from the tool show very high speedups for local and parallel execution on multi-cores over state-of-the-art compiler frameworks from the research community as well as the best native production compilers. The system also enables the easy use of powerful empirical/iterative optimization for general arbitrarily nested loop sequences.

930 citations

Journal ArticleDOI
TL;DR: In a mouse model of intestinal manipulation, stimulation of the vagus nerve ameliorated surgery-induced inflammation and postoperative ileus by activating STAT3 in intestinal macrophages and it is concluded that the vagal anti-inflammatory pathway acts by α7 subunit–mediated Jak2-STAT3 activation.
Abstract: Acetylcholine released by efferent vagus nerves inhibits macrophage activation. Here we show that the anti-inflammatory action of nicotinic receptor activation in peritoneal macrophages was associated with activation of the transcription factor STAT3. STAT3 was phosphorylated by the tyrosine kinase Jak2 that was recruited to the alpha7 subunit of the nicotinic acetylcholine receptor. The anti-inflammatory effect of nicotine required the ability of phosphorylated STAT3 to bind and transactivate its DNA response elements. In a mouse model of intestinal manipulation, stimulation of the vagus nerve ameliorated surgery-induced inflammation and postoperative ileus by activating STAT3 in intestinal macrophages. We conclude that the vagal anti-inflammatory pathway acts by alpha7 subunit-mediated Jak2-STAT3 activation.

918 citations

Journal ArticleDOI
TL;DR: The unaccounted carbon sink is conservatively estimated at 112 ± 85 Tg C a 1, equivalent in magnitude to 30-40% of the global riverine organic carbon input to the coastal zone as mentioned in this paper.
Abstract: results in a conservative estimate of 218 ± 72 Tg C a 1 . When using the best available estimates of various carbon sinks (organic carbon export, sediment burial, and mineralization), it appears that >50% of the carbon fixed by mangrove vegetation is unaccounted for. This unaccounted carbon sink is conservatively estimated at 112 ± 85 Tg C a 1 , equivalent in magnitude to 30–40% of the global riverine organic carbon input to the coastal zone. Our analysis suggests that mineralization is severely underestimated, and that the majority of carbon export from mangroves to adjacent waters occurs as dissolved inorganic carbon (DIC). CO2 efflux from sediments and creek waters and tidal export of DIC appear to be the major sinks. These processes are quantitatively comparable in magnitude to the unaccounted carbon sink in current budgets, but are not yet adequately constrained with the limited published data available so far.

918 citations


Authors

Showing all 40485 results

NameH-indexPapersCitations
H. S. Chen1792401178529
John A. Rogers1771341127390
Omar M. Yaghi165459163918
Barry M. Popkin15775190453
John E. Morley154137797021
Claude Bouchard1531076115307
Ruth J. F. Loos14264792485
Ali Khademhosseini14088776430
Shanhui Fan139129282487
Joseph E. LeDoux13947891500
Christopher T. Walsh13981974314
Kenneth A. Dodge13846879640
Steven B. Heymsfield13267977220
George A. Bray131896100975
Zhanhu Guo12888653378
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202362
2022608
20213,042
20203,095
20192,874
20182,762