scispace - formally typeset
Search or ask a question
Institution

Louisiana State University

EducationBaton Rouge, Louisiana, United States
About: Louisiana State University is a education organization based out in Baton Rouge, Louisiana, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 40206 authors who have published 76587 publications receiving 2566076 citations. The organization is also known as: LSU & Louisiana State University and Agricultural and Mechanical College.
Topics: Population, Poison control, Wetland, Autism, Sediment


Papers
More filters
Journal ArticleDOI
TL;DR: Available data suggest that resin bonding to these materials is less predictable and requires substantially different bonding methods than to silica-based ceramics, and further in vitro studies, as well as controlled clinical trials, are needed.
Abstract: Current ceramic materials offer preferred optical properties for highly esthetic restorations. The inherent brittleness of some ceramic materials, specific treatment modalities, and certain clinical situations require resin bonding of the completed ceramic restoration to the supporting tooth structures for long-term clinical success. This article presents a literature review on the resin bond to dental ceramics. A PubMed database search was conducted for in vitro studies pertaining to the resin bond to ceramic materials. The search was limited to peer-reviewed articles published in English between 1966 and 2001. Although the resin bond to silica-based ceramics is well researched and documented, few in vitro studies on the resin bond to high-strength ceramic materials were identified. Available data suggest that resin bonding to these materials is less predictable and requires substantially different bonding methods than to silica-based ceramics. Further in vitro studies, as well as controlled clinical trials, are needed.

910 citations

Journal ArticleDOI
TL;DR: The possibility that multiple ROS sources contribute to reperfusion injury in most tissues is supported by evidence demonstrating that redox-signaling enables ROS produced by one enzymatic source to activate and enhance ROS production by a second source.
Abstract: Reperfusion injury, the paradoxical tissue response that is manifested by blood flow-deprived and oxygen-starved organs following the restoration of blood flow and tissue oxygenation, has been a focus of basic and clinical research for over 4-decades. While a variety of molecular mechanisms have been proposed to explain this phenomenon, excess production of reactive oxygen species (ROS) continues to receive much attention as a critical factor in the genesis of reperfusion injury. As a consequence, considerable effort has been devoted to identifying the dominant cellular and enzymatic sources of excess ROS production following ischemia-reperfusion (I/R). Of the potential ROS sources described to date, xanthine oxidase, NADPH oxidase (Nox), mitochondria, and uncoupled nitric oxide synthase have gained a status as the most likely contributors to reperfusion-induced oxidative stress and represent priority targets for therapeutic intervention against reperfusion-induced organ dysfunction and tissue damage. Although all four enzymatic sources are present in most tissues and are likely to play some role in reperfusion injury, priority and emphasis has been given to specific ROS sources that are enriched in certain tissues, such as xanthine oxidase in the gastrointestinal tract and mitochondria in the metabolically active heart and brain. The possibility that multiple ROS sources contribute to reperfusion injury in most tissues is supported by evidence demonstrating that redox-signaling enables ROS produced by one enzymatic source (e.g., Nox) to activate and enhance ROS production by a second source (e.g., mitochondria). This review provides a synopsis of the evidence implicating ROS in reperfusion injury, the clinical implications of this phenomenon, and summarizes current understanding of the four most frequently invoked enzymatic sources of ROS production in post-ischemic tissue.

910 citations

Journal ArticleDOI
TL;DR: A set of clinical criteria could be used to identify patients with minor head injury who do not need to undergo CT, and the use of CT can be safely limited to those who have certain clinical findings.
Abstract: Background Computed tomography (CT) is widely used as a screening test in patients with minor head injury, although the results are often normal. We performed a study to develop and validate a set of clinical criteria that could be used to identify patients with minor head injury who do not need to undergo CT. Methods In the first phase of the study, we recorded clinical findings in 520 consecutive patients with minor head injury who had a normal score on the Glasgow Coma Scale and normal findings on a brief neurologic examination; the patients then underwent CT. Using recursive partitioning, we derived a set of criteria to identify all patients who had abnormalities on CT scanning. In the second phase, the sensitivity and specificity of the criteria for predicting a positive scan were evaluated in a group of 909 patients. Results Of the 520 patients in the first phase, 36 (6.9 percent) had positive scans. All patients with positive CT scans had one or more of seven findings: headache, vomiting, an age ov...

906 citations

Journal ArticleDOI
TL;DR: Between these different mechanisms, Alu elements have not only contributed a great deal to the evolution of the genome but also continue to contribute to a significant portion of human genetic diseases.

900 citations

Journal ArticleDOI
TL;DR: Rabalais et al. as mentioned in this paper proposed that global climate changes will likely result in higher water temperatures, stronger stratification, and increased inflows of freshwater and nutrients to coastal waters in many areas of the globe.
Abstract: Rabalais, N. N., Turner, R. E., Diaz, R. J., and Justic, D. 2009. Global change and eutrophication of coastal waters. - ICES Journal of Marine Science, 66: 1528-1537.The cumulative effects of global change, including climate change, increased population, and more intense industrialization and agribusiness, will likely continue and intensify the course of eutrophication in estuarine and coastal waters. As a result, the symptoms of eutrophication, such as noxious and harmful algal blooms, reduced water quality, loss of habitat and natural resources, and severity of hypoxia (oxygen depletion) and its extent in estuaries and coastal waters will increase. Global climate changes will likely result in higher water temperatures, stronger stratification, and increased inflows of freshwater and nutrients to coastal waters in many areas of the globe. Both past experience and model forecasts suggest that these changes will result in enhanced primary production, higher phytoplankton and macroalgal standing stocks, and more frequent or severe hypoxia. The negative consequences of increased nutrient loading and stratification may be partly, but only temporarily, compensated by stronger or more frequent tropical storm activity in low and mid-latitudes. In anticipation of the negative effects of global change, nutrient loadings to coastal waters need to be reduced now, so that further water quality degradation is prevented.

899 citations


Authors

Showing all 40485 results

NameH-indexPapersCitations
H. S. Chen1792401178529
John A. Rogers1771341127390
Omar M. Yaghi165459163918
Barry M. Popkin15775190453
John E. Morley154137797021
Claude Bouchard1531076115307
Ruth J. F. Loos14264792485
Ali Khademhosseini14088776430
Shanhui Fan139129282487
Joseph E. LeDoux13947891500
Christopher T. Walsh13981974314
Kenneth A. Dodge13846879640
Steven B. Heymsfield13267977220
George A. Bray131896100975
Zhanhu Guo12888653378
Network Information
Related Institutions (5)
Pennsylvania State University
196.8K papers, 8.3M citations

93% related

University of Minnesota
257.9K papers, 11.9M citations

93% related

University of California, Davis
180K papers, 8M citations

92% related

University of Texas at Austin
206.2K papers, 9M citations

92% related

Ohio State University
222.7K papers, 8.3M citations

92% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202362
2022608
20213,042
20203,095
20192,874
20182,762