Louisiana State University

About: Louisiana State University is a education organization based out in Baton Rouge, Louisiana, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 40206 authors who have published 76587 publications receiving 2566076 citations. The organization is also known as: LSU & Louisiana State University and Agricultural and Mechanical College.

Zinc, Insulin and Diabetes

Abstract: The relationship between diabetes, insulin and zinc (Zn) is complex with no clear cause and effect relationships. In Type 1 diabetes there is a lack of insulin production, in Type 2 diabetes resistance to the effects of insulin are predominant. Both Type 1 and Type 2 have the same long-term complications. Diabetes effects zinc homeostasis in many ways, although it is most probably the hyperglycemia, rather than any primary lesion related to diabetes, which is responsible for the increased urinary loss and decreases in total body zinc. The role of Zn deficiency, which could, at least potentially, exacerbate the cytokine-induced damage in the autoimmune attack which destroys the islet cell in Type 1 diabetes, is unclear. Since Zn plays a clear role in the synthesis, storage and secretion of insulin as well as conformational integrity of insulin in the hexameric form, the decreased Zn, which affects the ability of the islet cell to produce and secrete insulin, might then compound the problem, particularly in Type 2 diabetes. Several of the complications of diabetes may be related to increased intracellular oxidants and free radicals associated with decreases in intracellular Zn and in Zn dependent antioxidant enzymes. There appears to be a complex interrelationship between Zn and both Type 1 and Type 2 diabetes. The role of Zn in the clinical management of diabetes, its complications, or in its prevention is, at best, unclear.

Analysis of role conflict and role ambiguity in a structural equations framework

Abstract: In this study a confirmatory methodology was implemented to analyze a model that uses the Rizzo, House, and Lirtzman (1970) scales of role conflict (RC) and role ambiguity (RA; i.e., the Bedeian and Armenakis, 1981, model). The validity of the RC and RA scales were examined through structural equations analysis, and a nested models approach was used to compare the Bedeian and Armenakis model with a model suggesting a more parsimonious representation of the data. Furthermore, path estimates from models incorporating random measurement error were compared with estimates from a model not incorporating the effects of random measurement error