Institution
Louisiana State University
Education•Baton Rouge, Louisiana, United States•
About: Louisiana State University is a education organization based out in Baton Rouge, Louisiana, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 40206 authors who have published 76587 publications receiving 2566076 citations. The organization is also known as: LSU & Louisiana State University and Agricultural and Mechanical College.
Topics: Population, Poison control, Wetland, Autism, Sediment
Papers published on a yearly basis
Papers
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TL;DR: The results suggest that marine populations can remain demographically closed for thousands of generations despite extended larval duration, and that recognition cues such as color may promote speciation when geographic barriers are transient or weak.
Abstract: The pelagic larvae of many marine organisms can potentially disperse across hundreds of kilometers, but whether oceanographic or behavioral mechanisms can constrain dispersal over periods sufficient for the evolution of genetic differentiation remains unclear. Here, we concurrently examine larval duration and genetic population differentiation in a cleaner goby, Elacatinus evelynae, a member of the most species-rich genus of Caribbean reef fishes. Despite evidence for extended pelagic duration (21 days), populations of E. evelynae show strong genetic differentiation: among color forms (1.36 to 3.04% divergent at mitochondrial cytochrome b) and among island populations within color forms (Phi(ST) up to 70%). These results suggest that marine populations can remain demographically closed for thousands of generations despite extended larval duration, and that recognition cues such as color may promote speciation when geographic barriers are transient or weak.
560 citations
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TL;DR: Nonlinear Model Predictive Control (NMPC) as discussed by the authors is the industry standard for controlling constrained multivariable nonlinear processes with a large operating regime, and it is well suited for controlling nonlinear process with constraints.
559 citations
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TL;DR: A new continuous control mechanism that compensates for uncertainty in a class of high-order, multiple-input-multiple-output nonlinear systems is presented and a new Lyapunov-based stability argument is employed to prove semiglobal asymptotic tracking.
Abstract: In this note, we present a new continuous control mechanism that compensates for uncertainty in a class of high-order, multiple-input-multiple-output nonlinear systems. The control strategy is based on limited assumptions on the structure of the system nonlinearities. A new Lyapunov-based stability argument is employed to prove semiglobal asymptotic tracking.
559 citations
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TL;DR: An extensive phylogenetic analysis of the wide-ranging and geographically variable Eastern Fence Lizard suggests "S. undulatus" represents at least four lineages that should be recognized as evolutionary species.
Abstract: Phylogenetic analysis of large datasets using complex nucleotide substitution models under a maximum likelihood framework can be computationally infeasible, especially when attempting to infer confidence values by way of nonparametric bootstrapping. Recent developments in phylogenetics suggest the computational burden can be reduced by using Bayesian methods of phylogenetic inference. However, few empirical phylogenetic studies exist that explore the efficiency of Bayesian analysis of large datasets. To this end, we conducted an extensive phylogenetic analysis of the wide-ranging and geographically variable Eastern Fence Lizard (Sceloporus undulatus). Maximum parsimony, maximum likelihood, and Bayesian phylogenetic analyses were performed on a combined mitochondrial DNA dataset (12S and 16S rRNA, ND1 protein-coding gene, and associated tRNA; 3,688 bp total) for 56 populations of S. undulatus (78 total terminals including other S. undulatus group species and outgroups). Maximum parsimony analysis resulted in numerous equally parsimonious trees (82,646 from equally weighted parsimony and 335 from weighted parsimony). The majority rule consensus tree derived from the Bayesian analysis was topologically identical to the single best phylogeny inferred from the maximum likelihood analysis, but required approximately 80% less computational time. The mtDNA data provide strong support for the monophyly of the S. undulatus group and the paraphyly of "S. undulatus" with respect to S. belli, S. cautus, and S. woodi. Parallel evolution of ecomorphs within "S. undulatus" has masked the actual number of species within this group. This evidence, along with convincing patterns of phylogeographic differentiation suggests "S. undulatus" represents at least four lineages that should be recognized as evolutionary species.
559 citations
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University of Washington1, Cold Spring Harbor Laboratory2, University of Auckland3, Harvard University4, University of Louisville5, Indiana University6, Indiana University – Purdue University Indianapolis7, Maine Medical Center8, Duke University9, University of Toledo10, Boston Children's Hospital11, Dartmouth College12, University of Pittsburgh13, University of Missouri14, Geisinger Medical Center15, Louisiana State University16, University of Pennsylvania17, University of Adelaide18, Veterans Health Administration19, University of California, San Diego20
TL;DR: The data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications.
Abstract: We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls (P = 0.0009, OR = 7.2) and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls (P = 0.028, OR = 2.5). Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents (P = 0.037, OR = 6). Probands were more likely to carry an additional large copy-number variant when compared to matched controls (10 of 42 cases, P = 5.7 x 10(-5), OR = 6.6). The clinical features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease.
558 citations
Authors
Showing all 40485 results
Name | H-index | Papers | Citations |
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H. S. Chen | 179 | 2401 | 178529 |
John A. Rogers | 177 | 1341 | 127390 |
Omar M. Yaghi | 165 | 459 | 163918 |
Barry M. Popkin | 157 | 751 | 90453 |
John E. Morley | 154 | 1377 | 97021 |
Claude Bouchard | 153 | 1076 | 115307 |
Ruth J. F. Loos | 142 | 647 | 92485 |
Ali Khademhosseini | 140 | 887 | 76430 |
Shanhui Fan | 139 | 1292 | 82487 |
Joseph E. LeDoux | 139 | 478 | 91500 |
Christopher T. Walsh | 139 | 819 | 74314 |
Kenneth A. Dodge | 138 | 468 | 79640 |
Steven B. Heymsfield | 132 | 679 | 77220 |
George A. Bray | 131 | 896 | 100975 |
Zhanhu Guo | 128 | 886 | 53378 |