Lund University

About: Lund University is a education organization based out in Lund, Sweden. It is known for research contribution in the topics: Population & Cancer. The organization has 42345 authors who have published 124676 publications receiving 5016438 citations. The organization is also known as: Lunds Universitet & University of Lund.

Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus.

Abstract: We carried out a multistage genome-wide association study of type 2 diabetes mellitus in Japanese individuals, with a total of 1,612 cases and 1,424 controls and 100,000 SNPs. The most significant association was obtained with SNPs in KCNQ1, and dense mapping within the gene revealed that rs2237892 in intron 15 showed the lowest P value (6.7 x 10(-13), odds ratio (OR) = 1.49). The association of KCNQ1 with type 2 diabetes was replicated in populations of Korean, Chinese and European ancestry as well as in two independent Japanese populations, and meta-analysis with a total of 19,930 individuals (9,569 cases and 10,361 controls) yielded a P value of 1.7 x 10(-42) (OR = 1.40; 95% CI = 1.34-1.47) for rs2237892. Among control subjects, the risk allele of this polymorphism was associated with impairment of insulin secretion according to the homeostasis model assessment of beta-cell function or the corrected insulin response. Our data thus implicate KCNQ1 as a diabetes susceptibility gene in groups of different ancestries.

Direct conversion of human fibroblasts to dopaminergic neurons

Abstract: Recent reports demonstrate that somatic mouse cells can be directly converted to other mature cell types by using combined expression of defined factors. Here we show that the same strategy can be applied to human embryonic and postnatal fibroblasts. By overexpression of the transcription factors Ascl1, Brn2, and Myt1l, human fibroblasts were efficiently converted to functional neurons. We also demonstrate that the converted neurons can be directed toward distinct functional neurotransmitter phenotypes when the appropriate transcriptional cues are provided together with the three conversion factors. By combining expression of the three conversion factors with expression of two genes involved in dopamine neuron generation, Lmx1a and FoxA2, we could direct the phenotype of the converted cells toward dopaminergic neurons. Such subtype-specific induced neurons derived from human somatic cells could be valuable for disease modeling and cell replacement therapy.

Algorithm and implementation of the K-best sphere decoding for MIMO detection

Abstract: K-best Schnorr-Euchner (KSE) decoding algorithm is proposed in this paper to approach near-maximum-likelihood (ML) performance for multiple-input-multiple-output (MIMO) detection. As a low complexity MIMO decoding algorithm, the KSE is shown to be suitable for very large scale integration (VLSI) implementations and be capable of supporting soft outputs. Modified KSE (MKSE) decoding algorithm is further proposed to improve the performance of the soft-output KSE with minor modifications. Moreover, a VLSI architecture is proposed for both algorithms. There are several low complexity and low-power features incorporated in the proposed algorithms and the VLSI architecture. The proposed hard-output KSE decoder and the soft-output MKSE decoder is implemented for 4/spl times/4 16-quadrature amplitude modulation (QAM) MIMO detection in a 0.35-/spl mu/m and a 0.13-/spl mu/m CMOS technology, respectively. The implemented hard-output KSE chip core is 5.76 mm/sup 2/ with 91 K gates. The KSE decoding throughput is up to 53.3 Mb/s with a core power consumption of 626 mW at 100 MHz clock frequency and 2.8 V supply. The implemented soft-output MKSE chip can achieve a decoding throughput of more than 100 Mb/s with a 0.56 mm/sup 2/ core area and 97 K gates. The implementation results show that it is feasible to achieve near-ML performance and high detection throughput for a 4/spl times/4 16-QAM MIMO system using the proposed algorithms and the VLSI architecture with reasonable complexity.

Rare earth elements in soil and plant systems - A review

Abstract: The rare earth elements (REEs) form a chemically uniform group and include yttrium (Y), lanthanum (La) and the lanthanides cerium (Ce), praseodymium (Pr), neodymium (Nd), promethium (Pm), samarium (Sm), europium (Eu), gadolinium (Gd), terbium (Tb), dysprosium (Dy), holmium (Ho), erbium (Er), thulium (Tm), ytterbium (Yb), and lutetium (Lu) Their average abundance in the Earth’s crust range from 66µg g−1 in Ce to 05µg g−1 in Tm and «01µg g−1 in Pm Recent great improvements in more routine analytical technique, the use of REEs as fertilisers, at least in East Asian agriculture, and the importance of these elements as indicators in both pedological and physiological processes and reactions have contributed to an increased interest in these previously less considered elements in environmental sciences This review of recent and current literature deals with REEs in primary and secondary soil minerals, concentrations in surface soils, factors influencing adsorption, solubility and transport in soils, including weathering and transformations of REE minerals, and vertical distribution in soil profiles Reviewed and discussed are also concentrations, distribution and localisation of REEs in plants and plant organs, soil-plant relationships and interactions, effects on plant growth and crop production and their importance in plant physiology and biochemistry The REEs are found, usually several elements together, as phosphates, carbonates and silicate minerals finely dispersed especially in magmatic and metamorphic rocks REE concentrations in surface soils of humid climates, such as the A(E)-horizons of Podzols and Laterites, are usually lower than in the parent material, due to higher weathering and leaching rates than of the average soil constituents Some fractionation may occur due to the formation of more element-specific secondary minerals Transfer from soil to plant is usually low, but extreme accumulators are found, eg, among several species of ferns Roots have generally higher concentrations than shoots Possible uptakemechanisms of REEs are discussed Uptake is positively, though often weakly, correlated with soil acidity and easily soluble concentrations of the elements, but rarely well related to their total concentrations in the soil Under certain conditions, low concentrations of at least some REEs seem to favour plant growth and productivity, but the physiological mechanisms are still not well understood Some considerations concerning the boundary between essential and non-essential micro nutrients are discussed

Taking the Linguistic Turn in Organizational Research: Challenges, Responses, Consequences

Abstract: This article takes the linguistic turn, or turns, in the social sciences as its point of departure and discusses the implications for methodology, empirical research, and field practices in social and organizational studies. Various responses can be identified: grounded fictionalism, giving up the hope of making substantive, empirical claims in terms of research texts capturing social phenomena; data-constructionism, where the ambiguous and constructed nature of empirical material gives space for a more relaxed, freer, and bolder way of interacting with empirical material; and discursivism, in which the researcher concentrates on the details of empirical material that lends itself to representations in the form of language, for example, conversations and texts. The article develops some ideas for a more reflective way of dealing with language issues in empirical social research. It argues for a more discourse-near but not discourse-exclusive approach to organizational research and refers to this as discur...