Institution
Lund University
Education•Lund, Sweden•
About: Lund University is a education organization based out in Lund, Sweden. It is known for research contribution in the topics: Population & Cancer. The organization has 42345 authors who have published 124676 publications receiving 5016438 citations. The organization is also known as: Lunds Universitet & University of Lund.
Topics: Population, Cancer, Breast cancer, Insulin, Transplantation
Papers published on a yearly basis
Papers
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TL;DR: It is demonstrated that lipopolysaccharide-induced inflammation, which gives rise to microglia activation in the area where the new neurons are born, strongly impairs basal hippocampal neurogenesis in rats, raising the possibility that suppression of hippocampal Neurogenesis by activatedmicroglia contributes to cognitive dysfunction in aging, dementia, epilepsy, and other conditions leading to brain inflammation.
Abstract: New hippocampal neurons are continuously generated in the adult brain. Here, we demonstrate that lipopolysaccharide-induced inflammation, which gives rise to microglia activation in the area where the new neurons are born, strongly impairs basal hippocampal neurogenesis in rats. The increased neurogenesis triggered by a brain insult is also attenuated if it is associated with microglia activation caused by tissue damage or lipopolysaccharide infusion. The impaired neurogenesis in inflammation is restored by systemic administration of minocycline, which inhibits microglia activation. Our data raise the possibility that suppression of hippocampal neurogenesis by activated microglia contributes to cognitive dysfunction in aging, dementia, epilepsy, and other conditions leading to brain inflammation.
1,457 citations
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Tufts Medical Center1, University of Southampton2, University of Oxford3, University of Melbourne4, Erasmus University Rotterdam5, Duke University6, Lund University7, University of Otago8, McMaster University9, University of A Coruña10, National Autonomous University of Mexico11, Peking University12, Hospital for Special Surgery13, University of Tampere14, Health Science University15, University of Delaware16, Drexel University17, University of Warwick18, Coventry Health Care19
TL;DR: These guidelines offer comprehensive and patient-centered treatment profiles for individuals with Knee, Hip, and Polyarticular OA that are derived from expert consensus and based on objective review of high-quality meta-analytic data.
1,453 citations
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TL;DR: Results indicate that PsbS, an intrinsic chlorophyll-binding protein of photosystem II, is necessary for nonphotochemical quenching but not for efficient light harvesting and photosynthesis, a finding that has implications for the functional evolution of pigment-binding proteins.
Abstract: Photosynthetic light harvesting in plants is regulated in response to changes in incident light intensity. Absorption of light that exceeds a plant's capacity for fixation of CO2 results in thermal dissipation of excitation energy in the pigment antenna of photosystem II by a poorly understood mechanism. This regulatory process, termed nonphotochemical quenching, maintains the balance between dissipation and utilization of light energy to minimize generation of oxidizing molecules, thereby protecting the plant against photo-oxidative damage. To identify specific proteins that are involved in nonphotochemical quenching, we have isolated mutants of Arabidopsis thaliana that cannot dissipate excess absorbed light energy. Here we show that the gene encoding PsbS, an intrinsic chlorophyll-binding protein of photosystem II, is necessary for nonphotochemical quenching but not for efficient light harvesting and photosynthesis. These results indicate that PsbS may be the site for nonphotochemical quenching, a finding that has implications for the functional evolution of pigment-binding proteins.
1,427 citations
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Bjerknes Centre for Climate Research1, Stockholm University2, Saint Petersburg State University3, Russian Academy of Sciences4, University of Cambridge5, Geological Museum6, Gas Technology Institute7, Lund University8, University of Copenhagen9, Alfred Wegener Institute for Polar and Marine Research10, University of Iceland11, University of New Hampshire12, Geological Survey of Sweden13, University of Oulu14, Aarhus University15, Ohio State University16, Geological Survey of Finland17, University of Bristol18, Leibniz Association19
TL;DR: In this paper, the maximum limits of the Eurasian ice sheets during four glaciations have been reconstructed: (1) the Late Saalian (>140 ka), (2) the Early Weichselian (100-80 ka),(3) the Middle Weichsellian (60-50 ka), and (4) the late Weichselsian (25-15 ka) based on satellite data and aerial photographs combined with geological field investigations in Russia and Siberia, and with marine seismic and sediment core data.
1,426 citations
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TL;DR: A very high prevalence of radiographic knee OA, pain, and functional limitations was observed in young women who sustained an ACL tear during soccer play 12 years earlier, constituting a strong rationale to direct increased efforts toward prevention and better treatment of knee injury.
Abstract: Objective
To determine the prevalence of radiographic knee osteoarthritis (OA) as well as knee-related symptoms and functional limitations in female soccer players 12 years after an anterior cruciate ligament (ACL) injury.
Methods
Female soccer players who sustained an ACL injury 12 years earlier were examined with standardized weight-bearing knee radiography and 2 self-administered patient questionnaires, the Knee Injury and Osteoarthritis Outcome Score questionnaire and the Short Form 36-item health survey. Joint space narrowing and osteophytes were graded according to the radiographic atlas of the Osteoarthritis Research Society International. The cutoff value to define radiographic knee OA approximated a Kellgren/Lawrence grade of 2.
Results
Of the available cohort of 103 female soccer players, 84 (82%) answered the questionnaires and 67 (65%) consented to undergo knee radiography. The mean age at assessment was 31 years (range 26–40 years) and mean body mass index was 23 kg/m2 (range 18–40 kg/m2). Fifty-five women (82%) had radiographic changes in their index knee, and 34 (51%) fulfilled the criterion for radiographic knee OA. Of the subjects answering the questionnaires, 63 (75%) reported having symptoms affecting their knee-related quality of life, and 28 (42%) were considered to have symptomatic radiographic knee OA. Slightly more than 60% of the players had undergone reconstructive surgery of the ACL. Using multivariate analyses, surgical reconstruction was found to have no significant influence on knee symptoms.
Conclusion
A very high prevalence of radiographic knee OA, pain, and functional limitations was observed in young women who sustained an ACL tear during soccer play 12 years earlier. These findings constitute a strong rationale to direct increased efforts toward prevention and better treatment of knee injury.
1,425 citations
Authors
Showing all 42777 results
Name | H-index | Papers | Citations |
---|---|---|---|
Yi Chen | 217 | 4342 | 293080 |
Fred H. Gage | 216 | 967 | 185732 |
Kari Stefansson | 206 | 794 | 174819 |
Mark I. McCarthy | 200 | 1028 | 187898 |
Ruedi Aebersold | 182 | 879 | 141881 |
Jie Zhang | 178 | 4857 | 221720 |
Feng Zhang | 172 | 1278 | 181865 |
Martin G. Larson | 171 | 620 | 117708 |
Michael Snyder | 169 | 840 | 130225 |
Unnur Thorsteinsdottir | 167 | 444 | 121009 |
Anders Björklund | 165 | 769 | 84268 |
Carl W. Cotman | 165 | 809 | 105323 |
Dennis R. Burton | 164 | 683 | 90959 |
Jaakko Kaprio | 163 | 1532 | 126320 |
Panos Deloukas | 162 | 410 | 154018 |